Epigenetic Deregulation of Protocadherin PCDHGC3 in Pheochromocytomas/Paragangliomas Associated With SDHB Mutations

SDHB mutations are found in an increasing number of neoplasms, most notably in paragangliomas and pheochromocytomas (PPGLs). SDHB-PPGLs are slow-growing tumors, but ∼50% of them may develop metastasis. The molecular basis of metastasis in these tumors is a long-standing and unresolved problem. Thus,...

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Published in:	The journal of clinical endocrinology and metabolism Vol. 104; no. 11; pp. 5673 - 5692
Main Authors:	Bernardo-Castiñeira, Cristóbal, Valdés, Nuria, Celada, Lucía, Martinez, Andrés San José, Sáenz-de-Santa-María, I, Bayón, Gustavo F, Fernández, Agustín F, Sierra, Marta I, Fraga, Mario F, Astudillo, Aurora, Jiménez-Fonseca, Paula, Rial, Juan Carlos, Hevia, Miguel Ángel, Turienzo, Estrella, Bernardo, Carmen, Forga, Lluis, Tena, Isabel, Molina-Garrido, María-José, Cacho, Laura, Villabona, Carles, Serrano, Teresa, Scola, Bartolomé, Chirivella, Isabel, Del Olmo, Maribel, Menéndez, Carmen Luz, Navarro, Elena, Tous, María, Vallejo, Ana, Athimulam, Shobana, Bancos, Irina, Suarez, Carlos, Chiara, María-Dolores
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01-11-2019
Subjects:	Cell migration Cell proliferation Deoxyribonucleic acid DNA DNA fingerprinting DNA methylation Epigenetic inheritance Epigenetics Evidence-based medicine Gene clusters Genes Genetic aspects Genetic diversity Genomes Genomics Metastases Metastasis Methylation Mutation Neuroendocrine tumors Paraganglioma Protocadherin Tumors Spain
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