Dysregulation of Thymic Clonal Deletion and the Escape of Autoreactive T Cells

Events ongoing in the thymus are critical for deleting developing thymocytes specific for tissue antigens, and establishing self-tolerance within the T cell compartment. Aberrant thymic negative selection, however, is believed to generate a repertoire with increased self-reactivity, which in turn ca...

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Bibliographic Details
Published in:	Archivum Immunologiae et Therapiae Experimentalis Vol. 58; no. 6; pp. 449 - 457
Main Authors:	Kroger, Charles J, Flores, Rafael R, Morillon, Maurice, Wang, Bo, Tisch, Roland
Format:	Journal Article
Language:	English
Published:	Basel Basel : SP Birkhäuser Verlag Basel 01-12-2010 SP Birkhäuser Verlag Basel Springer Nature B.V
Subjects:	Animals antigen-presenting cells Autoimmunity Biomedical and Life Sciences Biomedicine Central tolerance Clonal Deletion Humans Immune Tolerance Immunology Lymphocyte Activation Pharmacology/Toxicology Review T-Lymphocytes - immunology thymocytes Thymus Gland - immunology Autoimmunity Thymocytes Central tolerance Antigen-presenting cells
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Summary:	Events ongoing in the thymus are critical for deleting developing thymocytes specific for tissue antigens, and establishing self-tolerance within the T cell compartment. Aberrant thymic negative selection, however, is believed to generate a repertoire with increased self-reactivity, which in turn can contribute to the development of T cell-mediated autoimmunity. In this review, mechanisms that regulate the efficacy of negative selection and influence the deletion of autoreactive thymocytes will be discussed.
Bibliography:	http://dx.doi.org/10.1007/s00005-010-0100-3 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Feature-1
ISSN:	0004-069X 1661-4917
DOI:	10.1007/s00005-010-0100-3