Spectrophotometric determination of piroxicam

• Published in: Journal of analytical chemistry (New York, N.Y.) Vol. 66; no. 4; pp. 378 - 383
• Main Authors: Kormosh, Zh. A., Hunka, I. P., Bazel, Y. R.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01-04-2011; Springer
• Subjects: Analytical Chemistry; Chemistry; Chemistry and Materials Science; Piroxicam; Toluene; piroxicam; spectrophotometric determination; polymethine dye
• ISSN: 1061-9348; 1608-3199
• DOI: 10.1134/S1061934811020079

The possibility of the spectrophotometric determination of piroxicam based on the extraction of its ion associate (
IA
) with the polymethine dye, 5-thiocyanate-1,3,3-trimethyl-2[(1E)-3-[(2E)-1,3,3-trime-thyl-1-
H
-indol-2-ilidine]-propenyl]-3
H
-indolium chloride. The maximal recovery of IA with toluene is achieved when pH of the aqueous phase is 8.0–12.0 and the concentration of the dye is (1.0–2.0) × 10
−4
. The molar absorption coefficient of IA is 8 × 10
4
, the detection limit of piroxicam is 0.49 μg/mL. A procedure has been developed for the extraction-spectrophotometric determination of piroxicam in the concentration range 1.0–20.0 μg/mL.