Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour

Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour

In addition to its well-known role as an energy repository, adipose tissue is one of the largest endocrine organs in the organism due to its ability to synthesize and release different bioactive molecules. Two main types of adipose tissue have been described, namely white adipose tissue (WAT) with a...

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Published in:International journal of molecular sciences Vol. 22; no. 11; p. 5560
Main Authors: Álvarez-Artime, Alejandro, García-Soler, Belén, Sainz, Rosa María, Mayo, Juan Carlos
Format: Journal Article
Language:English
Published: MDPI 24-05-2021
MDPI AG
Subjects:
adipose tissue
browning
prostate cancer
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Abstract In addition to its well-known role as an energy repository, adipose tissue is one of the largest endocrine organs in the organism due to its ability to synthesize and release different bioactive molecules. Two main types of adipose tissue have been described, namely white adipose tissue (WAT) with a classical energy storage function, and brown adipose tissue (BAT) with thermogenic activity. The prostate, an exocrine gland present in the reproductive system of most mammals, is surrounded by periprostatic adipose tissue (PPAT) that contributes to maintaining glandular homeostasis in conjunction with other cell types of the microenvironment. In pathological conditions such as the development and progression of prostate cancer, adipose tissue plays a key role through paracrine and endocrine signaling. In this context, the role of WAT has been thoroughly studied. However, the influence of BAT on prostate tumor development and progression is unclear and has received much less attention. This review tries to bring an update on the role of different factors released by WAT which may participate in the initiation, progression and metastasis, as well as to compile the available information on BAT to discuss and open a new field of knowledge about the possible protective role of BAT in prostate cancer.
AbstractList In addition to its well-known role as an energy repository, adipose tissue is one of the largest endocrine organs in the organism due to its ability to synthesize and release different bioactive molecules. Two main types of adipose tissue have been described, namely white adipose tissue (WAT) with a classical energy storage function, and brown adipose tissue (BAT) with thermogenic activity. The prostate, an exocrine gland present in the reproductive system of most mammals, is surrounded by periprostatic adipose tissue (PPAT) that contributes to maintaining glandular homeostasis in conjunction with other cell types of the microenvironment. In pathological conditions such as the development and progression of prostate cancer, adipose tissue plays a key role through paracrine and endocrine signaling. In this context, the role of WAT has been thoroughly studied. However, the influence of BAT on prostate tumor development and progression is unclear and has received much less attention. This review tries to bring an update on the role of different factors released by WAT which may participate in the initiation, progression and metastasis, as well as to compile the available information on BAT to discuss and open a new field of knowledge about the possible protective role of BAT in prostate cancer.
Author García-Soler, Belén
Mayo, Juan Carlos
Álvarez-Artime, Alejandro
Sainz, Rosa María
AuthorAffiliation 3 Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Avda. Hospital Universitario s/n, 33011 Oviedo, Spain
1 Departamento de Morfología y Biología Celular, Redox Biology Unit, University of Oviedo, Facultad de Medicina, Julián Clavería 6, 33006 Oviedo, Spain; alejandroalvarezartime@gmail.com (A.Á.-A.); belengaso.ies@gmail.com (B.G.-S.); sainzrosa@uniovi.es (R.M.S.)
2 Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Santiago Gascón Building, Fernando Bongera s/n, 33006 Oviedo, Spain
AuthorAffiliation_xml – name: 3 Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Avda. Hospital Universitario s/n, 33011 Oviedo, Spain
– name: 1 Departamento de Morfología y Biología Celular, Redox Biology Unit, University of Oviedo, Facultad de Medicina, Julián Clavería 6, 33006 Oviedo, Spain; alejandroalvarezartime@gmail.com (A.Á.-A.); belengaso.ies@gmail.com (B.G.-S.); sainzrosa@uniovi.es (R.M.S.)
– name: 2 Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Santiago Gascón Building, Fernando Bongera s/n, 33006 Oviedo, Spain
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  givenname: Alejandro
  orcidid: 0000-0001-9677-6804
  surname: Álvarez-Artime
  fullname: Álvarez-Artime, Alejandro
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  givenname: Belén
  surname: García-Soler
  fullname: García-Soler, Belén
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  givenname: Rosa María
  orcidid: 0000-0003-3048-5582
  surname: Sainz
  fullname: Sainz, Rosa María
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  givenname: Juan Carlos
  orcidid: 0000-0002-0882-2047
  surname: Mayo
  fullname: Mayo, Juan Carlos
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SubjectTerms adipose tissue
browning
prostate cancer
Review
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Title Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour
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