Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties

Curcumin ( ) and ten derivatives ( - ) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic mye...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 22; no. 4; p. 633
Main Authors:	Lozada-García, María Concepción, Enríquez, Raúl G, Ramírez-Apán, Teresa O, Nieto-Camacho, Antonio, Palacios-Espinosa, Juan Francisco, Custodio-Galván, Zeltzin, Soria-Arteche, Olivia, Pérez-Villanueva, Jaime
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 14-04-2017 MDPI
Subjects:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antioxidants Antioxidants - chemical synthesis Antioxidants - pharmacology Biotechnology Cell Line, Tumor Cell Survival Chronic myeloid leukemia Curcumin Curcumin - analogs & derivatives Curcumin - chemical synthesis Curcumin - pharmacology Cytotoxicity Free Radical Scavengers - chemical synthesis Free Radical Scavengers - pharmacology Glioblastoma Humans Inhibitory Concentration 50 Leukemia Lung cancer Molecular Structure Myeloid leukemia Non-small cell lung carcinoma Quercetin Rats Sulforhodamine Thiobarbituric acid Tocopherol Tumor cell lines antioxidant azoles cytotoxic curcumin
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Summary:	Curcumin ( ) and ten derivatives ( - ) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC ) values for the more active compounds against HCT-15 and K562 cell lines. Compounds and were the most active against both cell lines and were more active than curcumin itself. Thiobarbituric acid reactive substances (TBARS) assay showed that has potent activity; even stronger than curcumin, α-tocopherol, and quercetin.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. This paper was written in memory of Dra. María Concepción Lozada-García.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules22040633