Quinic acid derivatives inhibit dengue virus replication in vitro

• Published in: Virology journal Vol. 12; no. 1; p. 223
• Main Authors: Zanello, Paula Rodrigues, Koishi, Andrea Cristine, Rezende Júnior, Celso de Oliveira, Oliveira, Larissa Albuquerque, Pereira, Adriane Antonia, de Almeida, Mauro Vieira, Duarte dos Santos, Claudia Nunes, Bordignon, Juliano
• Format: Journal Article
• Language: English
• Published: England BioMed Central 22-12-2015
• Subjects: Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antiviral Agents - toxicity; Cell Line; Cell Survival - drug effects; Culicidae; Dengue Virus - drug effects; Dengue Virus - physiology; Hepatocytes - drug effects; Humans; Microbial Sensitivity Tests; Microbial Viability - drug effects; Models, Molecular; Molecular Structure; Quinic Acid - analogs & derivatives; Quinic Acid - chemistry; Quinic Acid - pharmacology; Quinic Acid - toxicity; Virus Replication - drug effects
• ISSN: 1743-422X; 1743-422X
• DOI: 10.1186/s12985-015-0443-9

Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk.
With the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line (Huh7.5). Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells.
Taken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection.