Action site of bisphenol A as metabolic disruptor lies in the tryptophan-nicotinamide conversion pathway

We have reported that the administration of bisphenol A to rats reduces the conversion ratio of tryptophan to nicotinamide. In the present paper, we show that bisphenol A, a monomer of polycarbonate plastics, inhibits the enzyme activity of kynurenine 3-hydroxylase. Namely, the conversion ratio of t...

Full description

Saved in:

Bibliographic Details
Published in:	Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) Vol. 45; no. 5; pp. 231 - 238
Main Authors:	Fukuwatari, T. (Shiga Prefectural Univ., Hikone (Japan)), Suzuura, C, Sasaki, R, Shibata, K
Format:	Journal Article
Language:	Japanese
Published:	Japan Japanese Society for Food Hygiene and Safety 01-10-2004
Subjects:	Air Pollutants, Occupational - pharmacology Animals Benzhydryl Compounds bisphenol A ENDOCRINE DISEASES endocrine disruptor kynurenine 3-hydroxylase Kynurenine 3-Monooxygenase Male METABOLIC DISORDERS metabolic disruptor Mixed Function Oxygenases - antagonists & inhibitors Niacinamide - metabolism NICOTINAMIDE Organ Size - drug effects PHENOLIC COMPOUNDS Phenols - pharmacology Rats Rats, Wistar Thiamine - urine TRYPTOPHAN Tryptophan - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We have reported that the administration of bisphenol A to rats reduces the conversion ratio of tryptophan to nicotinamide. In the present paper, we show that bisphenol A, a monomer of polycarbonate plastics, inhibits the enzyme activity of kynurenine 3-hydroxylase. Namely, the conversion ratio of tryptophan to nicotinamide is reduced through the inhibition of kynurenine 3-hydroxylase activity by bisphenol A.
Bibliography:	T01 2005002858
ISSN:	0015-6426 1882-1006
DOI:	10.3358/shokueishi.45.231