Extraction-spectrophotometric determination of mefenamic acid in pharmaceutical preparations

The optimal conditions of the formation and extraction of mefenamic acid ion associates with the astrafloxin polymethine dye are studied. The extraction of ion associates with isooctane-dichloroethane mixtures attains a maximum at pH 9–11 and dye concentration of (5–7) × 10 −5 M. The Beer law is ful...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of analytical chemistry (New York, N.Y.) Vol. 69; no. 10; pp. 960 - 964
Main Authors:	Kormosh, Zh. A., Matviichuk, O. Yu, Bazel’, Ya. R.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-10-2014 Springer
Subjects:	Analytical Chemistry Chemical properties Chemistry Chemistry and Materials Science Extraction (Chemistry) Identification and classification Mefenamic acid Methods Spectrophotometry spectrophotometry determination mefenamic acid
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The optimal conditions of the formation and extraction of mefenamic acid ion associates with the astrafloxin polymethine dye are studied. The extraction of ion associates with isooctane-dichloroethane mixtures attains a maximum at pH 9–11 and dye concentration of (5–7) × 10 −5 M. The Beer law is fulfilled in the range 2.0–21.0 μg/mL; the detection limit for mefenamic acid is 0.72 μg/mL. A method is developed for the extraction-spectrophotometric determination of mefenamic acid in pharmaceutical preparations.
ISSN:	1061-9348 1608-3199
DOI:	10.1134/S1061934814100074