Perturbation of epidermal growth factor clearance after radioiodination and its implications

The clearance of human epidermal growth factor (hEGF1-53) has been thought to be mediated mainly by a high-capacity receptor system, yet relatively low in vivo clearance rates (<10 mL/min/kg) and long terminal elimination half-lives (>120 min) have been observed in rats receiving the peptide t...

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Bibliographic Details
Published in:	Journal of pharmaceutical sciences Vol. 86; no. 3; p. 290
Main Authors:	Kuo, B S, Nordblom, G D, Wright, D S
Format:	Journal Article
Language:	English
Published:	United States 01-03-1997
Subjects:	Amino Acid Sequence Animals Epidermal Growth Factor - blood Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacokinetics Iodine Radioisotopes Male Molecular Sequence Data Peptide Fragments - blood Peptide Fragments - metabolism Peptide Fragments - pharmacokinetics Precipitin Tests Rats Rats, Wistar Receptor, Epidermal Growth Factor - metabolism Trichloroacetic Acid
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