Tissue culture model of Krabbe's disease: psychosine cytotoxicity in rat oligodendrocyte culture

Krabbe's disease (globoid cell leukodystrophy) is a progressive cerebral degenerative disease of infancy characterized by severe myelin loss and the presence of globoid bodies in the white matter. Previous studies have suggested that psychosine is the causative agent for the pathogenesis of Kra...

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Bibliographic Details
Published in:	Developmental neuroscience Vol. 19; no. 4; p. 321
Main Authors:	Cho, K H, Kim, M W, Kim, S U
Format:	Journal Article
Language:	English
Published:	Switzerland 1997
Subjects:	Albumins - pharmacology Animals Brain - pathology Cell Survival - drug effects Cells, Cultured Dimethyl Sulfoxide - pharmacology Hypoglycemic Agents - pharmacology Insulin - pharmacology Insulin-Like Growth Factor I - pharmacology Leukodystrophy, Globoid Cell - pathology Neuroprotective Agents - pharmacology Oligodendroglia - drug effects Phorbol Esters - pharmacology Psychosine - antagonists & inhibitors Psychosine - toxicity Rats
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