Evidence for a graft-versus-leukemia effect after allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes

We report the results of a prospective study of a reduced-intensity conditioning (RIC) regimen followed by allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA-identical sibling in 37 patients with acute myeloid leukemia (AML; n = 17) or myelodysplastic syndrome (MDS; n = 20). T...

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Bibliographic Details
Published in:	Blood Vol. 100; no. 6; pp. 2243 - 2245
Main Authors:	Martino, Rodrigo, Caballero, Marı́a Dolores, Pérez Simón, José Antonio, Canals, Carmen, Solano, Carlos, Urbano-Ispı́zua, Alvaro, Bargay, Joan, Léon, Angel, Sarrá, Josep, Sanz, Guillermo F., Moraleda, José Marı́a, Brunet, Salut, San Miguel, Jesús, Sierra, Jorge
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 15-09-2002 The Americain Society of Hematology
Subjects:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Busulfan - administration & dosage Female Follow-Up Studies Graft vs Host Disease Graft vs Leukemia Effect Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - adverse effects Humans Incidence Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - mortality Prospective Studies Survival Analysis Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Conditioning - methods Transplantation, Isogeneic - adverse effects Vidarabine - administration & dosage Vidarabine - analogs & derivatives Human Graft versus leukemia reaction Acute Stem cell Related donor Hematopoietic cell Homograft Malignant hemopathy Non myeloablative treatment Myelodysplastic syndrome Blood cell Treatment Graft Conditioning Therapeutic protocol Histocompatibility Acute myelocytic leukemia
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