Synthesis of hexyl butyrate (apple and citrus aroma) by Candida rugosa lipase immobilized on Diaion HP-20 using the Box-Behnken design
This study aims at the synthesis of hexyl butyrate by Candida rugosa lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of support), whose hydrolytic activity was 132.0 ± 2.5 U/g. To obtain the maximum production of hexyl butyrate, the Box-Behnken desi...
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| Published in: | Food science and biotechnology Vol. 32; no. 5; pp. 689 - 696 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-04-2023
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| Abstract | This study aims at the synthesis of hexyl butyrate by
Candida rugosa
lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of support), whose hydrolytic activity was 132.0 ± 2.5 U/g. To obtain the maximum production of hexyl butyrate, the Box-Behnken design statistical planning was used, having as independent variables; biocatalyst concentration, temperature and acid:alcohol molar ratio and ester conversion as a dependent variable at 60, 180 and 480 min. For 60 min, 90.8% conversion was obtained at 47.25 ºC, 1:1.4 molar ratio and 17.65% of biocatalyst; 180 min, 94.5% conversion at 59.5 ºC, 1:2 molar ratio and 15.8% biocatalyst; 480 min, 95.01% conversion at 47.0 ºC, 1:2 molar ratio and 16.9% biocatalyst. CRL-Diaion HP 20 retained 60% of its initial activity after ten cycles of reactions showing potential for industrial use. The ester produced was identified by gas chromatography analyses. |
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| AbstractList | This study aims at the synthesis of hexyl butyrate by
lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of support), whose hydrolytic activity was 132.0 ± 2.5 U/g. To obtain the maximum production of hexyl butyrate, the Box-Behnken design statistical planning was used, having as independent variables; biocatalyst concentration, temperature and acid:alcohol molar ratio and ester conversion as a dependent variable at 60, 180 and 480 min. For 60 min, 90.8% conversion was obtained at 47.25 ºC, 1:1.4 molar ratio and 17.65% of biocatalyst; 180 min, 94.5% conversion at 59.5 ºC, 1:2 molar ratio and 15.8% biocatalyst; 480 min, 95.01% conversion at 47.0 ºC, 1:2 molar ratio and 16.9% biocatalyst. CRL-Diaion HP 20 retained 60% of its initial activity after ten cycles of reactions showing potential for industrial use. The ester produced was identified by gas chromatography analyses.
The online version contains supplementary material available at 10.1007/s10068-022-01200-1. This study aims at the synthesis of hexyl butyrate by Candida rugosa lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of support), whose hydrolytic activity was 132.0 ± 2.5 U/g. To obtain the maximum production of hexyl butyrate, the Box-Behnken design statistical planning was used, having as independent variables; biocatalyst concentration, temperature and acid:alcohol molar ratio and ester conversion as a dependent variable at 60, 180 and 480 min. For 60 min, 90.8% conversion was obtained at 47.25 ºC, 1:1.4 molar ratio and 17.65% of biocatalyst; 180 min, 94.5% conversion at 59.5 ºC, 1:2 molar ratio and 15.8% biocatalyst; 480 min, 95.01% conversion at 47.0 ºC, 1:2 molar ratio and 16.9% biocatalyst. CRL-Diaion HP 20 retained 60% of its initial activity after ten cycles of reactions showing potential for industrial use. The ester produced was identified by gas chromatography analyses. This study aims at the synthesis of hexyl butyrate by Candida rugosa lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of support), whose hydrolytic activity was 132.0 ± 2.5 U/g. To obtain the maximum production of hexyl butyrate, the Box-Behnken design statistical planning was used, having as independent variables; biocatalyst concentration, temperature and acid:alcohol molar ratio and ester conversion as a dependent variable at 60, 180 and 480 min. For 60 min, 90.8% conversion was obtained at 47.25 ºC, 1:1.4 molar ratio and 17.65% of biocatalyst; 180 min, 94.5% conversion at 59.5 ºC, 1:2 molar ratio and 15.8% biocatalyst; 480 min, 95.01% conversion at 47.0 ºC, 1:2 molar ratio and 16.9% biocatalyst. CRL-Diaion HP 20 retained 60% of its initial activity after ten cycles of reactions showing potential for industrial use. The ester produced was identified by gas chromatography analyses.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10068-022-01200-1. This study aims at the synthesis of hexyl butyrate by Candida rugosa lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of support), whose hydrolytic activity was 132.0 ± 2.5 U/g. To obtain the maximum production of hexyl butyrate, the Box-Behnken design statistical planning was used, having as independent variables; biocatalyst concentration, temperature and acid:alcohol molar ratio and ester conversion as a dependent variable at 60, 180 and 480 min. For 60 min, 90.8% conversion was obtained at 47.25 ºC, 1:1.4 molar ratio and 17.65% of biocatalyst; 180 min, 94.5% conversion at 59.5 ºC, 1:2 molar ratio and 15.8% biocatalyst; 480 min, 95.01% conversion at 47.0 ºC, 1:2 molar ratio and 16.9% biocatalyst. CRL-Diaion HP 20 retained 60% of its initial activity after ten cycles of reactions showing potential for industrial use. The ester produced was identified by gas chromatography analyses. |
| Author | Franco, Marcelo de Carvalho Tavares, Iasnaia Maria dos Santos, Marta Maria Oliveira Mendes, Adriano Aguiar do Espirito Santo, Eliézer Luz Ruiz, Héctor A. de Oliveira, Julieta Rangel de Menezes, Luiz Henrique Sales Gonçalves, Márcia Soares Salay, Luiz Carlos de Carvalho, Marise Silva |
| Author_xml | – sequence: 1 givenname: Marta Maria Oliveira surname: dos Santos fullname: dos Santos, Marta Maria Oliveira organization: Department of Exact Sciences and Natural, State University of Southwest Bahia – sequence: 2 givenname: Luiz Henrique Sales surname: de Menezes fullname: de Menezes, Luiz Henrique Sales organization: Department of Exact Sciences and Natural, State University of Southwest Bahia – sequence: 3 givenname: Eliézer Luz surname: do Espirito Santo fullname: do Espirito Santo, Eliézer Luz organization: Department of Exact Sciences and Natural, State University of Southwest Bahia – sequence: 4 givenname: Marise Silva surname: de Carvalho fullname: de Carvalho, Marise Silva organization: Department of Exact Sciences and Technology, State University of Santa Cruz – sequence: 5 givenname: Márcia Soares surname: Gonçalves fullname: Gonçalves, Márcia Soares organization: Department of Exact Sciences and Natural, State University of Southwest Bahia – sequence: 6 givenname: Iasnaia Maria surname: de Carvalho Tavares fullname: de Carvalho Tavares, Iasnaia Maria organization: Department of Exact Sciences and Natural, State University of Southwest Bahia – sequence: 7 givenname: Adriano Aguiar surname: Mendes fullname: Mendes, Adriano Aguiar organization: Institute of Chemistry, Federal University of Alfenas – sequence: 8 givenname: Héctor A. surname: Ruiz fullname: Ruiz, Héctor A. organization: Biorefinery Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila – sequence: 9 givenname: Luiz Carlos surname: Salay fullname: Salay, Luiz Carlos organization: Department of Exact Sciences and Technology, State University of Santa Cruz – sequence: 10 givenname: Marcelo surname: Franco fullname: Franco, Marcelo organization: Department of Exact Sciences and Technology, State University of Santa Cruz – sequence: 11 givenname: Julieta Rangel orcidid: 0000-0001-8571-7294 surname: de Oliveira fullname: de Oliveira, Julieta Rangel email: jroliveira@uesc.br organization: Department of Exact Sciences and Technology, State University of Santa Cruz |
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| Cites_doi | 10.1016/j.enzmictec.2015.12.007 10.1016/j.biortech.2020.124561 10.1016/j.foodchem.2019.05.179 10.1016/0003-2697(76)90527-3 10.1016/j.bcab.2020.101885 10.1016/j.foodchem.2018.10.140 10.1080/15422119.2018.1564328 10.1016/j.biortech.2020.122887 10.1016/j.ijbiomac.2020.11.011 10.1016/j.apsusc.2020.145481 10.1016/j.micromeso.2020.110576 10.1016/j.biotechadv.2005.09.003 10.1016/j.ijbiomac.2012.01.020 10.1016/j.procbio.2018.01.028 10.1515/boca-2018-0002 10.1016/j.cej.2016.11.069 10.1002/bab.1959 10.3390/catal10020218 10.1016/j.tifs.2017.09.004 10.1021/bm800609g 10.1016/j.procbio.2016.11.019 10.1016/j.ijbiomac.2020.07.021 10.1016/j.biortech.2020.124614 10.1016/j.ijbiomac.2016.07.097 10.1016/j.ijbiomac.2014.06.035 10.1007/s10529-021-03196-w 10.1016/j.enzmictec.2007.01.018 10.1002/pca.3109 10.1080/10826068.2020.1815061 |
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| Snippet | This study aims at the synthesis of hexyl butyrate by
Candida rugosa
lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of... This study aims at the synthesis of hexyl butyrate by lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of lipase/g of... This study aims at the synthesis of hexyl butyrate by Candida rugosa lipase (CRL) immobilized on Diaion HP 20. The lipase load used was 28.7 ± 2.1 mg/g (mg of... |
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| SubjectTerms | Aroma Candida rugosa Chemistry Chemistry and Materials Science Conversion Dependent variables Food Science Gas chromatography Independent variables Industrial applications Lipase Nutrition Research Article Synthesis |
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| Title | Synthesis of hexyl butyrate (apple and citrus aroma) by Candida rugosa lipase immobilized on Diaion HP-20 using the Box-Behnken design |
| URI | https://link.springer.com/article/10.1007/s10068-022-01200-1 https://www.ncbi.nlm.nih.gov/pubmed/37009043 https://www.proquest.com/docview/2791991379 https://search.proquest.com/docview/2794688960 https://pubmed.ncbi.nlm.nih.gov/PMC10050618 |
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