Distinguishing Between Long-Transient and Asymptotic States in a Biological Aggregation Model

• Published in: Bulletin of mathematical biology Vol. 86; no. 3; p. 28
• Main Authors: Potts, Jonathan R., Painter, Kevin J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-03-2024; Springer Nature B.V
• Subjects: Asymptotic properties; Biological models (mathematics); Cell Biology; Diffusion; Life Sciences; Mathematical and Computational Biology; Mathematical models; Mathematics; Mathematics and Statistics; Original; Original Article; Steady state; Aggregation–diffusion equation; Long transients; Biological aggregation; Asymptotics; Nonlocal advection; Metastability
• ISSN: 0092-8240; 1522-9602
• DOI: 10.1007/s11538-023-01254-0

Aggregations are emergent features common to many biological systems. Mathematical models to understand their emergence are consequently widespread, with the aggregation–diffusion equation being a prime example. Here we study the aggregation–diffusion equation with linear diffusion in one spatial dimension. This equation is known to support solutions that involve both single and multiple aggregations. However, numerical evidence suggests that the latter, which we term ‘multi-peaked solutions’ may often be long-transient solutions rather than asymptotic steady states. We develop a novel technique for distinguishing between long transients and asymptotic steady states via an energy minimisation approach. The technique involves first approximating our study equation using a limiting process and a moment closure procedure. We then analyse local minimum energy states of this approximate system, hypothesising that these will correspond to asymptotic patterns in the aggregation–diffusion equation. Finally, we verify our hypotheses through numerical investigation, showing that our approximate analytic technique gives good predictions as to whether a state is asymptotic or transient. Overall, we find that almost all twin-peaked, and by extension multi-peaked, solutions are transient, except for some very special cases. We demonstrate numerically that these transients can be arbitrarily long-lived, depending on the parameters of the system.