Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

• Published in: EPJ Web of conferences Vol. 77; pp. 00021 - 1-00021-7
• Main Authors: Rabus, Hans, Palmans, Hugo, Hilgers, Gerhard, Sharpe, Peter, Pinto, Massimo, Villagrasa, Carmen, Nettelbeck, Heidi, Moro, Davide, Pola, Andrea, Pszona, Stanislaw, Teles, Pedro
• Format: Journal Article
• Language: English
• Published: EDP Sciences 01-01-2014
• Subjects: Biological effects; Deoxyribonucleic acid; Ion beams; Nanostructure; Packages; Particle tracks; Radiation damage; Radiotherapy; Research projects
• ISSN: 2100-014X; 2100-014X
• DOI: 10.1051/epjconf/20147700021

Funded within the European Metrology Research Programme (EMRP) [1], the joint research project "Biologically weighted quantities in radiotherapy" (BioQuaRT) [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 mu m), and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.