Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates

• Published in: Advances in materials science and engineering Vol. 2018; no. 2018; pp. 1 - 6
• Main Authors: Popović Bajić, Marijana, Tomanović, Nada, Prokić, Bogomir Bolka, Čolović, Božana, Jokanović, Vukoman, Živković, Slavoljub
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2018; Hindawi; Hindawi Limited
• Subjects: Biocompatibility; Blood cells; Calcium silicates; Cement; Experiments; Fluorides; Gangrene; Histopathology; Hydroxyapatite; In vivo methods and tests; Kidneys; Laboratory animals; Liver; Medical equipment; Medical research; Nanotechnology; Parameters; Rats; Rodents; Silica; Silicates; Skin; Spleen; Toxicity; Toxicology
• ISSN: 1687-8434; 1687-8442
• DOI: 10.1155/2018/8493439

As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.