Reaction of an Antioxidant (Sodium Sulfite) with 3-Hydroxy-6-Methyl-2-Ethylpyridinium Salts

The reaction of an antioxidant excipient (sodium sulfite) with 3-hydroxy-6-methyl-2-ethylpyridinium hydrochloride drug substance was studied using thermal analysis of the solid drug substances and biological testing on cell culture (Spirotox model) in aqueous solutions of various isotopic compositio...

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Published in:	Pharmaceutical chemistry journal Vol. 48; no. 12; pp. 840 - 842
Main Authors:	Timorovich, O. V., Lyulina, E. B., Pleteneva, T. V., Maksimova, T. V., Syroeshkin, A. V., Uspenskaya, E. V., Burdeinaya, T. N., Shandryuk, G. A.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-03-2015 Springer
Subjects:	Antioxidants (Nutrients) Medicine Methods of Analysis and Process Control Organic Chemistry Pharmacology/Toxicology Pharmacy Structure of Chemical Compounds Sulfites 3-hydroxy-6-methyl-2-ethylpyridine sodium sulfite drug substance Spirotox excipient thermal analysis
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Abstract	The reaction of an antioxidant excipient (sodium sulfite) with 3-hydroxy-6-methyl-2-ethylpyridinium hydrochloride drug substance was studied using thermal analysis of the solid drug substances and biological testing on cell culture (Spirotox model) in aqueous solutions of various isotopic compositions.
AbstractList	The reaction of an antioxidant excipient (sodium sulfite) with 3-hydroxy-6-methyl-2-ethylpyridinium hydrochloride drug substance was studied using thermal analysis of the solid drug substances and biological testing on cell culture (Spirotox model) in aqueous solutions of various isotopic compositions.
Audience	Academic
Author	Timorovich, O. V. Shandryuk, G. A. Maksimova, T. V. Pleteneva, T. V. Syroeshkin, A. V. Lyulina, E. B. Uspenskaya, E. V. Burdeinaya, T. N.
Author_xml	– sequence: 1 givenname: O. V. surname: Timorovich fullname: Timorovich, O. V. email: titorovicholga@gmail.com organization: Department of Pharmaceutical and Toxicological Chemistry, People’s Friendship University of Russia – sequence: 2 givenname: E. B. surname: Lyulina fullname: Lyulina, E. B. organization: Department of Pharmaceutical and Toxicological Chemistry, People’s Friendship University of Russia – sequence: 3 givenname: T. V. surname: Pleteneva fullname: Pleteneva, T. V. organization: Department of Pharmaceutical and Toxicological Chemistry, People’s Friendship University of Russia – sequence: 4 givenname: T. V. surname: Maksimova fullname: Maksimova, T. V. organization: Department of Pharmaceutical and Toxicological Chemistry, People’s Friendship University of Russia – sequence: 5 givenname: A. V. surname: Syroeshkin fullname: Syroeshkin, A. V. organization: Institute of Applied Geophysics – sequence: 6 givenname: E. V. surname: Uspenskaya fullname: Uspenskaya, E. V. organization: Department of Pharmaceutical and Toxicological Chemistry, People’s Friendship University of Russia – sequence: 7 givenname: T. N. surname: Burdeinaya fullname: Burdeinaya, T. N. organization: Legkaya Voda Co – sequence: 8 givenname: G. A. surname: Shandryuk fullname: Shandryuk, G. A. organization: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences; Laboratory of Polymer Modification
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References	A. I. Tentsova, O. I. Tereshkina, I. P. Rudakova, et al., Farmatsiya, No. 7, 3 – 6 (2012). RoweRCSheskeyPJOwenSCHandbook of Pharmaceutical Excipients20065LondonPharmaceutical Press708710 TOXNET Database of the US National Library of Medicine, ChemIDplusA; http://chem.sis.nlm.nih.gov/chemidpls/rn/109-00-2. OliphantTMitraAWilkinsonMContact Dermatitis20126631281301:CAS:528:DC%2BC38Xlt1SqtrY%3D2232066610.1111/j.1600-0536.2011.02029.x C. Baraldi, A. Tinti, S. Ottani, and M. C. Gamberini, J. Pharm. Biomed. Anal., No. 100, 239 – 240 (2014). T. N. Burdeinaya, O. Yu. Zrelov, T. V. Maksimova, et al., Vestn. RUDN, Ser. Med., No. 2, 5 – 9 (2013). E. B. Lyulina, K. Mvaituka, O. V. Titorovich, et al., in: Abstracts of Papers of the VIth All-Russian Scientific Conference “Young Pharmacy, Future Potential” [in Russian], St. Petersburg (2014), pp. 492 – 495. FariasMCarneiroRMolecules201419914128141381:CAS:528:DC%2BC2cXhs1yrtLfK2520771710.3390/molecules190914128 1206_CR5 1206_CR6 1206_CR4 1206_CR1 (1206_CR3) 2006 T Oliphant (1206_CR2) 2012; 66 M Farias (1206_CR7) 2014; 19 1206_CR8
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SubjectTerms	Antioxidants (Nutrients) Medicine Methods of Analysis and Process Control Organic Chemistry Pharmacology/Toxicology Pharmacy Structure of Chemical Compounds Sulfites
Title	Reaction of an Antioxidant (Sodium Sulfite) with 3-Hydroxy-6-Methyl-2-Ethylpyridinium Salts
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