Reaction of an Antioxidant (Sodium Sulfite) with 3-Hydroxy-6-Methyl-2-Ethylpyridinium Salts

The reaction of an antioxidant excipient (sodium sulfite) with 3-hydroxy-6-methyl-2-ethylpyridinium hydrochloride drug substance was studied using thermal analysis of the solid drug substances and biological testing on cell culture (Spirotox model) in aqueous solutions of various isotopic compositio...

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Bibliographic Details
Published in:	Pharmaceutical chemistry journal Vol. 48; no. 12; pp. 840 - 842
Main Authors:	Timorovich, O. V., Lyulina, E. B., Pleteneva, T. V., Maksimova, T. V., Syroeshkin, A. V., Uspenskaya, E. V., Burdeinaya, T. N., Shandryuk, G. A.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-03-2015 Springer
Subjects:	Antioxidants (Nutrients) Medicine Methods of Analysis and Process Control Organic Chemistry Pharmacology/Toxicology Pharmacy Structure of Chemical Compounds Sulfites 3-hydroxy-6-methyl-2-ethylpyridine sodium sulfite drug substance Spirotox excipient thermal analysis
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Summary:	The reaction of an antioxidant excipient (sodium sulfite) with 3-hydroxy-6-methyl-2-ethylpyridinium hydrochloride drug substance was studied using thermal analysis of the solid drug substances and biological testing on cell culture (Spirotox model) in aqueous solutions of various isotopic compositions.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-015-1206-z