Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

• Published in: Mechanisms of ageing and development Vol. 132; no. 3; pp. 131 - 139
• Main Authors: Vo, Thi Kim Duy, de Saint-Hubert, Marie, Morrhaye, Gabriel, Godard, Patrice, Geenen, Vincent, Martens, Henri J., Debacq-Chainiaux, Florence, Swine, Christian, Toussaint, Olivier
• Format: Journal Article Web Resource
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-03-2011; Elsevier; Elsevier Science Ireland
• Subjects: Adult; Aged; Aged, 80 and over; Ageing; Aging - blood; Biological and medical sciences; Biomarkers - blood; Communicable Diseases - blood; Development. Metamorphosis. Moult. Ageing; Female; Fundamental and applied biological sciences. Psychology; Gene expression; Geriatrics; Gériatrie; Heart failure; Heart Failure - blood; Hip Fractures; Hospitalization; Human health sciences; Humans; Immunologie & maladie infectieuse; Immunology & infectious disease; Immunosenescence; Inflammation; Male; Neutrophils - metabolism; Oxidative stress; Sciences de la santé humaine; Transcription, Genetic; Vertebrates: anatomy and physiology, studies on body, several organs or systems; CRP; RyR2; Heart failure; Oxidative stress; TCR; IL; Ageing; MHC; IGF-1; Inflammation; Gene expression; PBMC; TNF; versus; Egr; PMT; Immunosenescence; RT-qPCR; Human; Senescence; Diseases of the osteoarticular system; Biological marker; Cardiovascular disease; Fracture; Trauma; Hip; Infection; Vertebrata; Mammalia; Heart disease; Comparative study
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/j.mad.2011.02.002

► We identified 22 differentially abundant transcripts in heart failure in old persons. ► The results were compared to infectious diseases and hip fracture. ► Commonalities were found in the gene expression of the acute phase of the 3 diseases. ► We provide potential targets in heart failure, infectious diseases and hip fracture. ► We discuss the results in regard with geriatric frailty.
The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart failure and at recovery. This study identified 22 transcripts differentially abundant in acute phase of heart failure versus healthy aged subjects. Transcripts involved in inflammation and oxidative stress were more abundant. Those associated with T-cell functions were less abundant. The results were compared to two other major acute geriatric issues: infectious diseases and hip fracture. In acute phase, compared to healthy aged subjects, the abundance of 15/22 transcripts was also altered in both geriatric infectious diseases and hip fracture. Many variations had not vanished at the recovery phase. The abundance of CD28, CD69, LCK, HMOX1, TNFRSF1A transcripts, known to be altered in healthy aged versus healthy young subjects, was further affected in acute phase of the three geriatric diseases considered. The transcript levels of BCL2, CASP8, CCL5, DDIT3, EGR3, IL10RB, IL1R2, SERPINB2 and TIMP1 were affected in all three pathological conditions compared to healthy aged, but not versus healthy young subjects. In conclusion, this work provides critical targets for therapeutic research on geriatric heart failure, infectious diseases and hip fracture.