Paraventricular nucleus neurons producing neurotensin after lipopolysaccharide treatment project to the median eminence

• Published in: Brain research Vol. 1030; no. 2; pp. 294 - 296
• Main Authors: Loum-Ribot, Elodie, Lafon, Pierrette, Chaigniau, Michel, Pape, Jean-Rémi, Tramu, Gérard, Corio, Marc
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 31-12-2004; Amsterdam Elsevier; New York, NY
• Subjects: Acute-Phase Reaction - chemically induced; Acute-Phase Reaction - metabolism; Amidines - metabolism; Animals; Biological and medical sciences; Biological Transport, Active; Fluorescent Dyes - metabolism; Fundamental and applied biological sciences. Psychology; General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions; Hypothalamo–pituitary–adrenal axis; Immune challenge; Inflammation - chemically induced; Inflammation - metabolism; Lipopolysaccharides; Male; Median eminence; Median Eminence - cytology; Median Eminence - physiology; Neural Pathways - cytology; Neural Pathways - immunology; Neural Pathways - metabolism; Neuroimmunomodulation - physiology; Neurons - immunology; Neurons - metabolism; Neurotensin; Neurotensin - immunology; Neurotensin - metabolism; Paraventricular Hypothalamic Nucleus - cytology; Paraventricular Hypothalamic Nucleus - immunology; Paraventricular Hypothalamic Nucleus - metabolism; Paraventricular nucleus; Rats; Rats, Wistar; Up-Regulation; Vertebrates: endocrinology; SSC; IL; Endocrine and autonomic regulation; PVN; Hypothalamo–pituitary–adrenal axis; i.p; Immune challenge; Paraventricular nucleus; Neurotensin; LPS; PB; GHRH; CRH; HPA; Median eminence; GnRH; Rat; Hypothalamohypophysoadrenal axis; Hypothalamo-pituitary-adrenal axis; Rodentia; Central nervous system; Neuroendocrine regulation; Neuropeptide; Encephalon; Vertebrata; Mammalia; Neuron; Lipopolysaccharide; Pituitary gland
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2004.09.011

Inflammation consists in secretion of cytokines that stimulate the hypothalamo–pituitary–adrenal (HPA) axis to release the anti-inflammatory corticosterone. Upstream in this axis are corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) whose multipeptidergic phenotype changes: both corticotropin-releasing hormone mRNAs and neurotensin mRNAs are up-regulated. Combining in situ hybridization with a retrograde neuronal marker, we demonstrated that neurotensin-containing neurons in the paraventricular nucleus project to the median eminence.