Muscle weakness in west Nile Encephalitis Is Due to Destruction of Motor Neurons

The microglial inflammation was present in decreasing intensity in the medulla (in gray matter more than in white matter), cerebellum (especially the dentate nucleus, Purkinje cell layer, and molecular layer), thalamus (but not in the internal capsule), hippocampus (gray and white matter), and cereb...

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Bibliographic Details
Published in:	Human pathology Vol. 34; no. 6; pp. 628 - 629
Main Authors:	Sampson, Barbara A., Nields, Henry, Armbrustmacher, Vernon, Asnis, Deborah S.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2003 Elsevier Limited
Subjects:	Aged Antibodies, Viral - immunology Antigens, Viral - blood Encephalitis Fatal Outcome Fatalities Humans Male Mosquitoes Motor Neurons - pathology Muscle Weakness - etiology Muscle Weakness - physiopathology Spinal Cord - pathology West Nile Fever - complications West Nile Fever - pathology West Nile Fever - physiopathology West Nile virus West Nile virus - immunology West Nile virus - isolation & purification
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Summary:	The microglial inflammation was present in decreasing intensity in the medulla (in gray matter more than in white matter), cerebellum (especially the dentate nucleus, Purkinje cell layer, and molecular layer), thalamus (but not in the internal capsule), hippocampus (gray and white matter), and cerebrum (gray and white matter). The Centers for Disease Control demonstrated West Nile virus by polymerase chain reaction in tissues from all major organs (personal communication, M. Layton, New York City Department of Health).
ISSN:	0046-8177 1532-8392
DOI:	10.1016/S0046-8177(03)00203-X