In vitro dissolution of sparingly water-soluble drug dosage forms

• Published in: International journal of pharmaceutics Vol. 125; no. 1; pp. 99 - 106
• Main Authors: Shah, Vinod P., Noory, Assad, Noory, Carol, McCullough, Bruce, Clarke, Sanford, Everett, Richard, Naviasky, Helen, Srinivasan, B.N., Fortman, Don, Skelly, Jerome P.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 17-10-1995; Elsevier
• Subjects: Biological and medical sciences; General pharmacology; Medical sciences; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Drug; Investigation method; Low; Water solubility; Dissolution; In vitro; Physicochemical properties
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/0378-5173(95)00123-Z

An in vitro procedure for the evaluation of sparingly water-soluble drug products has been developed and tested. The data on several sparingly water-soluble drug products, such as danazol capsules, megestrol acetate tablets, prazosin HCl capsules, and quinestrol tablets is presented. The procedure allows a systematic approach to evaluate the dissolution profiles of sparingly water-soluble drug products using various aqueous media including those containing a surfactant such as sodium lauryl sulfate. This approach assists the analyst in developing a sensitive and specific dissolution methodology to characterize the in vitro release pattern of sparingly water-soluble drug products.