Enhanced vaccine antigen delivery by Salmonella using antibiotic-free operator–repressor titration-based plasmid stabilisation compared to chromosomal integration

Live attenuated bacteria provide the potential to replace traditional needle-based vaccination with an orally administered vaccine. The heterologous antigen gene is usually transformed as a multi-copy plasmid into the bacterial cell, but plasmids in live bacterial vaccine strains are often unstable,...

Full description

Saved in:

Bibliographic Details
Published in:	Microbial pathogenesis Vol. 46; no. 4; pp. 201 - 206
Main Authors:	Leckenby, Matthew W., Spear, Abigail M., Neeson, Brendan N., Williamson, E. Diane, Cranenburgh, Rocky M., Atkins, Helen S.
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier India Pvt Ltd 01-04-2009 Elsevier
Subjects:	Animals Anthrax - prevention & control Anthrax Vaccines - genetics Anthrax Vaccines - immunology Antibodies Antibodies, Bacterial - blood Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacillus anthracis Bacterial Toxins - genetics Bacterial Toxins - immunology Bacteriology Biological and medical sciences Chromosomes Female Fundamental and applied biological sciences. Psychology Gene expression Genetic Vectors Genomic Instability Haemolysin Integration Mice Microbiology Miscellaneous Oral administration Plasmid stabilisation Plasmids Protective antigen protective antigen gene Salmonella Salmonella enterica Salmonella typhimurium - genetics Survival Analysis Titration Vaccination Vaccine delivery Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Salmonella Bacillus anthracis Plasmid stabilisation Protective antigen Haemolysin Vaccine delivery Microbiology Vaccine Bacillaceae Antigen Plasmid Antibiotic Bacillales Bacteria Hemolysin Enterobacteriaceae Quantitative analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!