(–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin

Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biolog...

Full description

Saved in:

Bibliographic Details
Published in:	Current issues in molecular biology Vol. 44; no. 9; pp. 3849 - 3858
Main Authors:	Takeda, Shuso, Hirao-Suzuki, Masayo, Shindo, Mitsuru, Aramaki, Hironori
Format:	Journal Article
Language:	English
Published:	MDPI 25-08-2022 MDPI AG
Subjects:	(–)-xanthatin cancer stem cells Communication GADD45G mammospheres MCF-7 cells
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biology, it is now critically important for anti-cancer agents to selectively target cancer stem cells (CSCs) in order to overcome cancer therapeutic resistance and recurrence. However, it has not yet been established whether (–)-xanthatin abrogates the formation of breast CSCs. In the present study, we utilized chemically synthesized pure (–)-xanthatin and a culture system to obtain mammospheres from human breast cancer MCF-7 cells, which are a CSC-enriched population. We herein demonstrated for the first time that (–)-xanthatin exhibited the ability to kill mammospheres, similar to salinomycin, an established selective killer of CSCs. A possible anti-proliferative mechanism toward mammospheres by (–)-xanthatin is discussed.
AbstractList	Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biology, it is now critically important for anti-cancer agents to selectively target cancer stem cells (CSCs) in order to overcome cancer therapeutic resistance and recurrence. However, it has not yet been established whether (–)-xanthatin abrogates the formation of breast CSCs. In the present study, we utilized chemically synthesized pure (–)-xanthatin and a culture system to obtain mammospheres from human breast cancer MCF-7 cells, which are a CSC-enriched population. We herein demonstrated for the first time that (–)-xanthatin exhibited the ability to kill mammospheres, similar to salinomycin, an established selective killer of CSCs. A possible anti-proliferative mechanism toward mammospheres by (–)-xanthatin is discussed.
Author	Shindo, Mitsuru Hirao-Suzuki, Masayo Takeda, Shuso Aramaki, Hironori
AuthorAffiliation	3 Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasuga-koen, Kasuga 816-8580, Japan 4 Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Fukuoka 815-8511, Japan 1 Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzou 1, Hiroshima 729-0292, Japan 2 Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Hiroshima 737-0112, Japan
AuthorAffiliation_xml	– name: 1 Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzou 1, Hiroshima 729-0292, Japan – name: 2 Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Hiroshima 737-0112, Japan – name: 3 Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasuga-koen, Kasuga 816-8580, Japan – name: 4 Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Fukuoka 815-8511, Japan
Author_xml	– sequence: 1 givenname: Shuso orcidid: 0000-0003-2193-1421 surname: Takeda fullname: Takeda, Shuso – sequence: 2 givenname: Masayo orcidid: 0000-0002-5626-1950 surname: Hirao-Suzuki fullname: Hirao-Suzuki, Masayo – sequence: 3 givenname: Mitsuru orcidid: 0000-0002-0588-8075 surname: Shindo fullname: Shindo, Mitsuru – sequence: 4 givenname: Hironori orcidid: 0000-0003-0499-0868 surname: Aramaki fullname: Aramaki, Hironori
BookMark	eNpVkctu1TAQhiNUJNrCjgfwskikOLHjCwukElFa0YpFQWJnTexJj6vEDnZSdHa8Q9-QJyHlVKhdzeif0ffP5aDYCzFgUbyu6DFjmr6zfuw4p5rWgj8r9isuZMkob_Ye5S-Kg5xvKG2kktV-MR39-X33pvwBYd7A7AOBTIB88cOAicSenC0jBPIxIeSZtBDsKl-2p6UklzCOMU8bTEhaHIb8npyQNo4TpBV0i-RqXtyW_PLzhlzB4EMct9aHl8XzHoaMrx7iYfH99NO39qy8-Pr5vD25KC2v-VyqjkpklQBhteuQdc6xBvpGcyYkxbpvuNKqEUxozWorey01astET7F3smKHxfmO6yLcmCn5EdLWRPDmnxDTtYE0ezugEbTWSmlZr3a8b5yuO82Ua7TqnK6UWFkfdqxp6UZ0FsOcYHgCfVoJfmOu463RfB2L6RVw9ABI8eeCeTajz3Y9GgSMSza1rMS6maru5367a7Up5pyw_29TUXP_ZfP4y-wvx5ecgA
CitedBy_id	crossref_primary_10_3390_ijms24097751 crossref_primary_10_3390_cimb45090464 crossref_primary_10_1016_j_cbpc_2024_109957
Cites_doi	10.1016/j.phymed.2013.03.006 10.1016/j.cell.2008.03.027 10.1055/s-0031-1298481 10.1182/blood-2004-10-4135 10.1073/pnas.0706728104 10.1055/s-2006-959537 10.1016/j.cell.2009.06.034 10.1016/j.bcp.2016.06.009 10.21873/anticanres.11507 10.1016/j.bbrc.2020.07.043 10.1007/s00018-016-2362-3 10.1186/bcr2111 10.4161/cc.4.1.1363 10.3727/105221611X13176664479241 10.1073/pnas.0402069101 10.1073/pnas.0530291100 10.1021/tx200046s 10.1038/sj.onc.1206755 10.1016/j.tox.2012.12.019 10.1007/978-3-030-94804-7_1 10.1038/ncb2293 10.2131/jts.38.547 10.1016/j.tet.2012.11.077 10.2131/fts.3.115 10.1248/bpb.b13-00757 10.1038/nrc3920 10.1016/j.tet.2010.08.061 10.2131/fts.2.233 10.1158/0008-5472.CAN-10-0732 10.1139/Y07-104 10.1371/journal.pone.0077281 10.1038/s41420-021-00667-x 10.1111/j.1476-5381.2010.01089.x 10.4103/0973-8258.69154 10.3390/molecules24020359
ContentType	Journal Article
Copyright	2022 by the authors. 2022
Copyright_xml	– notice: 2022 by the authors. 2022
DBID	AAYXX CITATION 7X8 5PM DOA
DOI	10.3390/cimb44090264
DatabaseName	CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE - Academic
DatabaseTitleList	CrossRef
Database_xml	– sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1467-3045
EndPage	3858
ExternalDocumentID	oai_doaj_org_article_60298897216a4f5d92b938d598bd9186 10_3390_cimb44090264
GrantInformation_xml	– fundername: Research Foundation for Pharmaceutical Sciences – fundername: JSPS KAKENHI grantid: 17K08402; 21K12261; 22K15288; 22H02744 – fundername: Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food industr – fundername: Cooperative Research Program of the Network Joint Research Center for Materials and Devices grantid: 20211327; 20221077; 2012320; 2013373; 20163071
GroupedDBID	--- 36B 53G 5GY AAYXX AENEX AFZYC ALMA_UNASSIGNED_HOLDINGS CITATION DIK E3Z EMB F5P FRP GROUPED_DOAJ GX1 IAO IHR INH ITC MODMG M~E OK1 PGMZT RNS RPM TR2 7X8 5PM
ID	FETCH-LOGICAL-c424t-8b07e316a6c9dbe3bdd35af5943670e2f5489856369932c7f979e9c36f0efd713
IEDL.DBID	RPM
ISSN	1467-3045 1467-3037
IngestDate	Tue Oct 22 15:13:03 EDT 2024 Tue Sep 17 21:36:05 EDT 2024 Sat Oct 05 06:20:27 EDT 2024 Thu Sep 26 20:47:08 EDT 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	9
Language	English
License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c424t-8b07e316a6c9dbe3bdd35af5943670e2f5489856369932c7f979e9c36f0efd713
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0003-2193-1421 0000-0002-0588-8075 0000-0003-0499-0868 0000-0002-5626-1950
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497939/
PQID	2716943811
PQPubID	23479
PageCount	10
ParticipantIDs	doaj_primary_oai_doaj_org_article_60298897216a4f5d92b938d598bd9186 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9497939 proquest_miscellaneous_2716943811 crossref_primary_10_3390_cimb44090264
PublicationCentury	2000
PublicationDate	20220825
PublicationDateYYYYMMDD	2022-08-25
PublicationDate_xml	– month: 8 year: 2022 text: 20220825 day: 25
PublicationDecade	2020
PublicationTitle	Current issues in molecular biology
PublicationYear	2022
Publisher	MDPI MDPI AG
Publisher_xml	– name: MDPI – name: MDPI AG
References	Wang (ref_18) 2019; 2 Wicha (ref_23) 2003; 100 Tao (ref_12) 2016; 115 Wesolowski (ref_17) 2011; 15 Zerbini (ref_31) 2004; 101 Humayun (ref_15) 2022; 1360 Matsuo (ref_13) 2010; 66 Li (ref_8) 2013; 20 Takeda (ref_7) 2013; 38 Yu (ref_10) 2015; 8 Takeda (ref_11) 2016; 3 Kim (ref_29) 2011; 162 Zerbini (ref_33) 2005; 4 Roussakis (ref_3) 1994; 60 Takeda (ref_36) 2014; 37 Kurosu (ref_28) 2003; 22 Koga (ref_26) 2020; 531 Zhang (ref_32) 2012; 78 Huang (ref_4) 2007; 85 Cao (ref_34) 2007; 104 Liu (ref_35) 2010; 70 Matsumoto (ref_14) 2013; 69 Mani (ref_20) 2008; 133 Kim (ref_30) 2017; 37 ref_24 Kamboj (ref_1) 2010; 4 Gupta (ref_21) 2009; 138 Morrison (ref_25) 2008; 10 Zhang (ref_16) 2021; 7 Zhang (ref_27) 2011; 13 ref_2 Ma (ref_22) 2015; 15 Guzman (ref_37) 2005; 105 Zhang (ref_19) 2017; 74 Takeda (ref_9) 2015; 2 Takeda (ref_5) 2011; 24 Takeda (ref_6) 2013; 305
References_xml	– volume: 20 start-page: 865 year: 2013 ident: ref_8 article-title: Characterization of xanthatin: Anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo publication-title: Phytomedicine doi: 10.1016/j.phymed.2013.03.006 contributor: fullname: Li – volume: 133 start-page: 704 year: 2008 ident: ref_20 article-title: The epithelial-mesenchymal transition generates cells with properties of stem cells publication-title: Cell doi: 10.1016/j.cell.2008.03.027 contributor: fullname: Mani – volume: 78 start-page: 890 year: 2012 ident: ref_32 article-title: Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells publication-title: Planta Med. doi: 10.1055/s-0031-1298481 contributor: fullname: Zhang – volume: 105 start-page: 4163 year: 2005 ident: ref_37 article-title: The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells publication-title: Blood doi: 10.1182/blood-2004-10-4135 contributor: fullname: Guzman – volume: 104 start-page: 15852 year: 2007 ident: ref_34 article-title: IκB kinase α kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0706728104 contributor: fullname: Cao – volume: 60 start-page: 473 year: 1994 ident: ref_3 article-title: Cytotoxic activity of xanthatin and the crude extracts of Xanthium strumarium publication-title: Planta Med. doi: 10.1055/s-2006-959537 contributor: fullname: Roussakis – volume: 138 start-page: 645 year: 2009 ident: ref_21 article-title: Identification of selective inhibitors of cancer stem cells by high-throughput screening publication-title: Cell doi: 10.1016/j.cell.2009.06.034 contributor: fullname: Gupta – volume: 115 start-page: 18 year: 2016 ident: ref_12 article-title: Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2016.06.009 contributor: fullname: Tao – volume: 37 start-page: 1747 year: 2017 ident: ref_30 article-title: Salinomycin induces reactive oxygen species and apoptosis in aggressive breast cancer cells as mediated with regulation of autophagy publication-title: Anticancer Res. doi: 10.21873/anticanres.11507 contributor: fullname: Kim – volume: 531 start-page: 215 year: 2020 ident: ref_26 article-title: Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2020.07.043 contributor: fullname: Koga – volume: 74 start-page: 777 year: 2017 ident: ref_19 article-title: Multidrug-resistant cancer cells and cancer stem cells hijack cellular systems to circumvent systemic therapies, can natural products reverse this? publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-016-2362-3 contributor: fullname: Zhang – volume: 10 start-page: 210 year: 2008 ident: ref_25 article-title: Breast cancer stem cells: Implications for therapy of breast cancer publication-title: Breast Cancer Res. doi: 10.1186/bcr2111 contributor: fullname: Morrison – volume: 4 start-page: 18 year: 2005 ident: ref_33 article-title: Life and death in cancer. GADD45 and are critical regulators of NF-κB mediated escape from programmed cell death publication-title: Cell Cycle doi: 10.4161/cc.4.1.1363 contributor: fullname: Zerbini – volume: 15 start-page: 105 year: 2011 ident: ref_17 article-title: Gene expression profiling: Changing face of breast cancer classification and management publication-title: Gene Expr. doi: 10.3727/105221611X13176664479241 contributor: fullname: Wesolowski – volume: 101 start-page: 13618 year: 2004 ident: ref_31 article-title: NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0402069101 contributor: fullname: Zerbini – volume: 100 start-page: 3983 year: 2003 ident: ref_23 article-title: Prospective identification of tumorigenic breast cancer cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0530291100 contributor: fullname: Wicha – volume: 24 start-page: 855 year: 2011 ident: ref_5 article-title: (–)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells publication-title: Chem. Res. Toxicol. doi: 10.1021/tx200046s contributor: fullname: Takeda – volume: 22 start-page: 4459 year: 2003 ident: ref_28 article-title: BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells publication-title: Oncogene doi: 10.1038/sj.onc.1206755 contributor: fullname: Kurosu – volume: 305 start-page: 1 year: 2013 ident: ref_6 article-title: (–)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: Role of topoisomerase IIα inhibition and reactive oxygen species publication-title: Toxicology doi: 10.1016/j.tox.2012.12.019 contributor: fullname: Takeda – volume: 1360 start-page: 1 year: 2022 ident: ref_15 article-title: GADD45 in stress signaling, cell cycle control, and apoptosis publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-3-030-94804-7_1 contributor: fullname: Humayun – volume: 13 start-page: 1092 year: 2011 ident: ref_27 article-title: FOXO1 is an essential regulator of pluripotency in human embryonic stem cells publication-title: Nat. Cell. Biol. doi: 10.1038/ncb2293 contributor: fullname: Zhang – volume: 38 start-page: 547 year: 2013 ident: ref_7 article-title: (–)-Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells publication-title: J. Toxicol. Sci. doi: 10.2131/jts.38.547 contributor: fullname: Takeda – volume: 69 start-page: 1043 year: 2013 ident: ref_14 article-title: Asymmetric total syntheses of xanthatin and 11,13-dihydroxanthatin using a stereocontrolled conjugate allylation to γ-butenolide publication-title: Tetrahedron doi: 10.1016/j.tet.2012.11.077 contributor: fullname: Matsumoto – volume: 3 start-page: 115 year: 2016 ident: ref_11 article-title: Possible involvement of FosB in (–)-xanthatin-mediated anti-proliferative effects in human cancer MDA-MB-231 cells publication-title: Fundam. Toxicol. Sci. doi: 10.2131/fts.3.115 contributor: fullname: Takeda – volume: 37 start-page: 331 year: 2014 ident: ref_36 article-title: Xanthocidin derivatives as topoisomerase IIα enzymatic inhibitors publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.b13-00757 contributor: fullname: Takeda – volume: 15 start-page: 261 year: 2015 ident: ref_22 article-title: Mechanisms of aromatase inhibitor resistance publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3920 contributor: fullname: Ma – volume: 66 start-page: 8407 year: 2010 ident: ref_13 article-title: Total synthesis of xanthanolides publication-title: Tetrahedron doi: 10.1016/j.tet.2010.08.061 contributor: fullname: Matsuo – volume: 8 start-page: 10355 year: 2015 ident: ref_10 article-title: Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells publication-title: Int. J. Clin. Exp. Pathol. contributor: fullname: Yu – volume: 2 start-page: 233 year: 2015 ident: ref_9 article-title: (–)-Xanthatin-mediated marked up-regulation of RhoB, a sensor for damaged DNA publication-title: Fundam. Toxicol. Sci. doi: 10.2131/fts.2.233 contributor: fullname: Takeda – volume: 70 start-page: 10464 year: 2010 ident: ref_35 article-title: The canonical NF-κB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-0732 contributor: fullname: Liu – volume: 85 start-page: 1160 year: 2007 ident: ref_4 article-title: Xanthatin and xanthinosin from the burs of Xanthium strumarium L. as potential anticancer agents publication-title: Can. J. Physiol. Pharmacol. doi: 10.1139/Y07-104 contributor: fullname: Huang – ident: ref_24 doi: 10.1371/journal.pone.0077281 – volume: 7 start-page: 271 year: 2021 ident: ref_16 article-title: Gadd45g initiates embryonic stem cell differentiation and inhibits breast cell carcinogenesis publication-title: Cell death Discov. doi: 10.1038/s41420-021-00667-x contributor: fullname: Zhang – volume: 162 start-page: 773 year: 2011 ident: ref_29 article-title: Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2010.01089.x contributor: fullname: Kim – volume: 2 start-page: 141 year: 2019 ident: ref_18 article-title: Drug resistance and combating drug resistance in cancer publication-title: Cancer Drug Resist. contributor: fullname: Wang – volume: 4 start-page: 129 year: 2010 ident: ref_1 article-title: Phytopharmacological review of Xanthium strumarium L. (Cocklebur) publication-title: Int. J. Green Pharm. doi: 10.4103/0973-8258.69154 contributor: fullname: Kamboj – ident: ref_2 doi: 10.3390/molecules24020359
SSID	ssj0057871 ssib044733985
Score	2.3631048
Snippet	Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits...
SourceID	doaj pubmedcentral proquest crossref
SourceType	Open Website Open Access Repository Aggregation Database
StartPage	3849
SubjectTerms	(–)-xanthatin cancer stem cells Communication GADD45G mammospheres MCF-7 cells
SummonAdditionalLinks	– databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ3NTtwwEMctQELiggotYvuBplIrwSHCiZ3Y7g0CK6SKXqASt8jxh1gJsojsHrj1HXhDnqQzyQKbExeuiZU4f4-TGWfmZ8Z-KGtlXZiaVm10InPvEqO8TFwqgnYu8JxT7fDZhfpzpU9OCZPzstUX5YT1eOBeuMOCGOG6Y8xYGXNvstoI7XOja29S3cO2uV4KptCSpFRCmFdHmMwy7euMcEpxofoUeGzDD93ktpaS0hMLOfg4dQz_geM5TJtc-g6NP7DNhQMJR33Ht9hKaLbZer-l5MNHdrf_9O_xILlCwa5R9AZsCxZ-dxV_MI3QLdrDMaWiz6CkIb-H83KcKDi3aJItUQYClOHmpv0FR1C-wsGBUg4fgBZu4QK9dyqGcJPmE_s7Pr0sz5LFrgqJk5mcJbrmKghUs3DG10HU3ovcxtxIYrmFLGIMg9IVokDXJXMqGmWCcaKIPESPMe0OW2umTdhlEBwGk9jGBudRcW2ijBwvr1xaRG2yEfv5LGd118MzKgw6SPZqWfYROyatX9oQ8ro7gIZQLQyhessQRuz780hVOEXov4dtwnTeVhkRgQhllo6YGgzh4I7DM83kuoNtG4nPL8zn9-jiF7aRUfUEx5dT_pWtze7n4Rtbbf18rzPf_7Ae8Qk priority: 102 providerName: Directory of Open Access Journals
Title	(–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells: A Comparative Study with Salinomycin
URI	https://search.proquest.com/docview/2716943811 https://pubmed.ncbi.nlm.nih.gov/PMC9497939 https://doaj.org/article/60298897216a4f5d92b938d598bd9186
Volume	44
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6RSkhcEE8RHtUigQQHN7Z3vQ9urWlUCQUhFaTerH3SSIkTxcmhN_4D_5Bfwsw6ofWVq71-6JtZ78z4m28JeSeN4VZoi1UblfHKu0xLzzNXsKCcC3mVY-_wxaX8eqU-n6NMTnXohUmkfWfnJ-1iedLOrxO3cr10kwNPbPJtVmuuwa30ZERGEBsOU3TOJWP6NgZGjyz6FiOYTTmTPfsdxuQTN19azpGZKPhgXUry_YOYc8iYvLMETR-Rh_vYkZ727_iY3AvtE3K_303y5ilZf_jz6_fH7Aqwuga8W2o6auiX1OxHV5Gmej09Qxb6ltZo7Q2d1dNM0pkBb-xQYCDQOiwW3Sd6SutbXXCKbMMbijVbegmBO_ZBuHn7jPyYnn-vL7L9hgqZ4yXfZsrmMrBCGOG0t4FZ71llYqU5yriFMkL6AtAJJiBqKZ2MAHPQjomYh-ghnX1OjtpVG14QGhzkkTDGBOcBcaUjjzncXrpCRKXLMXl_gLNZ97oZDeQbCHtzF_YxOUOs_41Btet0YLX52ext3gjUiVdJZ8jwWHldWs2Ur7SyXhdKjMnbg6UamB34y8O0YbXrmhLFgFDFrBgTOTDh4InDM-B2SWd772Yv__vKV-RBid0SOXyMqtfkaLvZhTdk1Pndccr9j5Pn_gVse_Jo
link.rule.ids	230,315,729,782,786,866,887,2108,27935,27936,53803,53805
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF7RIgSXlqdIKbBIIMHBje1d76O31jQKalMhtUi9Wet90EiJE8XJoTf-A_-QX9IZO6H1tVfv-rXfrHdm_M23hHyWxvBS6BKzNirimbORlo5HNmFeWevjLMba4eGFPL9S309QJifb1MI0pH1bjg-qyfSgGl833Mr51PY3PLH-z1GuuQaz0v0t8hjma8y6QTrnkjF95wWjTSZtkRHMp5jJlv8OfeK-HU9LzpGbKHhnZWoE_DteZ5czeW8RGuw-8PGfk52110mP2uYX5JGvXpIn7T6UN6_I_Ou_P3-_RVcwyteAVEVNTQ09bcoE6SzQJtNPj5G_vqQ52smCjvJBJOnIgB3XKE3gae4nk_qQHtH8TlGcIk_xhmK2l16Ay48VFHZcvSa_BieX-TBab8UQWZ7yZaTKWHqWCCOsdqVnpXMsMyHTHAXgfBog8IEhF0yAv5NaGeANvbZMhNgHB4HwG7JdzSr_llBvIQKFPsZbB0gpHXiI4fLSJiIonfbIlw0MxbxV3CggUkG4ivtw9cgxYvS_D-pkNwdmi9_FergLgQrzqlEoMjxkTqelZsplWpVOJ0r0yKcNwgXMK_xZYio_W9VFijJCqH-W9IjsQN-5Y7cFEG8UutcI7z34zI_k6fBydFac_Tg_fUeepVhzEcMnLdsn28vFyr8nW7VbfWjs_hasiQcf
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JbtswECWaFC16Sdeg7soCLdAeFC2kuPSWKDFSpA4CpAVyEygujQFbNiz7kFv-oX_YL-mMZCfRtb1KIwnkG4oz5JtHQj5KY3gldIWrNiriubORlo5HNmVeWeuTPMHa4eNzeXqhDo9QJufmqK-WtG-r8V49me7V48uWWzmf2njDE4vPRoXmGtxKx3MX4i1yH8ZskvcTdc4lY_o2Eka_TLtCIxhTCZMdBx5sktiOpxXnyE8UvDc7tSL-vcizz5u8MxENH_9HE56QnXX0Sfc7k6fknq-fkQfdeZRXz8n885_r31-iC-jtS0Cspqahhp605YJ0Fmi74k8PkMe-pAX6y4KOimEk6ciAPzcoUeBp4SeT5ivdp8WtsjhFvuIVxVVfeg6hP1ZS2HH9gvwcHv0ojqP1kQyR5RlfRqpKpGepMMJqV3lWOcdyE3LNUQjOZwESIOh2wQTEPZmVAVrptWUiJD44SIh3yXY9q_1LQr2FTBRsjLcO0FI68JDA66VNRVA6G5BPGyjKeae8UULGgpCVdyEbkAPE6cYG9bLbC7PFr3Ld5aVApXnVKhUZHnKns0oz5XKtKqdTJQbkwwblEsYXbpqY2s9WTZmhnBDqoKUDInvw977YvwOot0rda5Rf_fOT78nDs8Nh-f3b6clr8ijD0osE_mz5G7K9XKz8W7LVuNW71vX_AvpsCZ8
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%28-%29-Xanthatin+as+a+Killer+of+Human+Breast+Cancer+MCF-7+Mammosphere+Cells%3A+A+Comparative+Study+with+Salinomycin&rft.jtitle=Current+issues+in+molecular+biology&rft.au=Takeda%2C+Shuso&rft.au=Hirao-Suzuki%2C+Masayo&rft.au=Shindo%2C+Mitsuru&rft.au=Aramaki%2C+Hironori&rft.date=2022-08-25&rft.eissn=1467-3045&rft.volume=44&rft.issue=9&rft.spage=3849&rft.epage=3858&rft_id=info:doi/10.3390%2Fcimb44090264&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1467-3045&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1467-3045&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1467-3045&client=summon