All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, also known as ErbB or HER, plays crucial roles in the development of multicellular organisms. Mutations and over-expression of the ErbB receptors have been implicated in a variety of human cancers. It is widely thought...

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Bibliographic Details
Published in:	Journal of cell science Vol. 121; no. Pt 19; pp. 3207 - 3217
Main Authors:	Tao, Rong-Hua, Maruyama, Ichi N
Format:	Journal Article
Language:	English
Published:	England 01-10-2008
Subjects:	Animals Cell Line, Tumor Cell Nucleus - metabolism Cell Survival CHO Cells Cricetinae Cricetulus Endoplasmic Reticulum - metabolism Fluorescence Humans Intracellular Space - metabolism Ligands Mice Models, Biological NIH 3T3 Cells Protein Multimerization Protein Structure, Tertiary Protein Transport Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - metabolism Subcellular Fractions - metabolism
Online Access:	Get full text
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