Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

TNF-related apoptosis-inducing ligand (TRAIL) was initially described to induce apoptosis of tumor cells and/or virally infected cells, although sparing normal cells, and has been implicated in the pathogenesis of HIV disease. We previously identified TRAILshort, a TRAIL splice variant, in HIV-infec...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 200; no. 3; pp. 1110 - 1123
Main Authors:	Nie, Zilin, Aboulnasr, Fatma, Natesampillai, Sekar, Burke, Stephen P, Krogman, Ashton, Bren, Gary D, Chung, Thomas D Y, Anderson, Jeff R, Smart, Michele K, Katzmann, David J, Rajagopalan, Govindarajan, Cummins, Nathan W, Badley, Andrew D
Format:	Journal Article
Language:	English
Published:	United States American Association of Immunologists 01-02-2018
Subjects:	Alternative splicing Alternative Splicing - genetics Apoptosis Bystander Effect - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell Line, Tumor Cell Membrane - immunology Cellular Microenvironment - immunology HEK293 Cells HeLa Cells HIV Infections - immunology HIV Infections - pathology HIV Infections - virology Humans Jurkat Cells Ligands Pathogenesis Proteasomes Protein Isoforms - biosynthesis Protein Isoforms - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism TLR7 protein TLR9 protein TNF-Related Apoptosis-Inducing Ligand - biosynthesis TNF-Related Apoptosis-Inducing Ligand - genetics Toll-like receptors TRAIL protein Tumor cells Tumor necrosis factor Ubiquitin
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