Correlation between Structural Transformations in Mesenteric Lymph Nodes and the Levels MicroRNA during Polychemotherapy of Breast Cancer

• Published in: Bulletin of experimental biology and medicine Vol. 172; no. 4; pp. 467 - 471
• Main Authors: Kabakov, A. V., Kazakov, O. V., Poveshchenko, A. F., Lykov, A. P., Raiter, T. V., Strunkin, D. N., Gulyaeva, L. F., Konenkov, V. I., Letyagin, A. Yu
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-02-2022; Springer; Springer Nature B.V
• Subjects: Animals; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological products; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cancer; Cell Biology; Chemotherapy; Female; Germinal centers; Health aspects; Internal Medicine; Laboratory Medicine; Lymph nodes; Lymph Nodes - pathology; Lymphatic system; Lymphoblasts; Macrophages; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Neoplasms - pathology; Pathology; Rats; Rats, Wistar; Rodents; breast cancer; microRNA; mesenteric lymph nodes; polychemotherapy
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05415-4

We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer. After polychemotherapy, significant correlations were found between miRNA-221 and the number of lymphoblasts in the germinal centers and between miRNA-222 and the number of lymphoblasts in the germinal centers and macrophages in the medullary cords of the mesenteric lymph nodes.