Trypanosoma cruzi: The role of PGE2 in immune response during the acute phase of experimental infection

Chagas disease is characterized by cardiac lesions and a high level of PGE2. Our objective was to investigate the role of PGE2 in cardiac lesions. BALB/c mice were infected with Trypanosoma cruzi (1 × 10 3 trypomastigote forms) and were treated daily with PBS, meloxicam (0.5 mg/kg) or etoricoxib (0....

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Bibliographic Details
Published in:	Experimental parasitology Vol. 118; no. 4; pp. 514 - 521
Main Authors:	Abdalla, G.K., Faria, G.E.L., Silva, K.T., Castro, E.C.C., Reis, M.A., Michelin, M.A.
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01-04-2008 Elsevier
Subjects:	Acute Disease Animals Biological and medical sciences bovine serum albumin BSA Cardiac lesions Cells, Cultured Chagas Disease - drug therapy Chagas Disease - immunology Chagas Disease - pathology COX COX-2 cyclooxygenase Cyclooxygenase 1 - analysis Cyclooxygenase 2 - analysis Cyclooxygenase Inhibitors - therapeutic use Cytokines degree Celsius Dinoprostone - biosynthesis Dinoprostone - physiology Fibrosis Fundamental and applied biological sciences. Psychology hematoxylin–eosin hour IFN-γ immunoglobulin interferon γ interleukin Life cycle. Host-agent relationship. Pathogenesis major histocompatibility complex Male mg/kg MHC Mice Mice, Inbred BALB C micro Currier micrograms per milliliter milligrams per kilogram Myocardium - enzymology Myocardium - pathology nanograms per milliliter ng/ml nitric oxide Parasitemia - drug therapy Parasitemia - parasitology PBS PGE 2 phosphate buffered saline Prostaglandin prostaglandin E 2 Prostaglandins - analysis Protozoa Pyridines - therapeutic use Spleen - chemistry Spleen - cytology Sulfones - therapeutic use T helper T. cruzi Thiazines - therapeutic use Thiazoles - therapeutic use TNF-α Trypanosoma cruzi Trypanosoma cruzi - immunology tumor necrosis factor α μCi μg/ml PBS NO IL C Prostaglandin Cytokines COX-2 PGE 2 h ng/ml MHC T. cruzi μCi μg/ml COX BSA Cardiac lesions IFN-γ TNF-α Th HE Ig mg/kg Kinetoplastida Infection Protozoa Immune response Acute Parasite Organism defense Experimental study Trypanosoma cruzi
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