Adenosine stimulates angiogenesis by up‐regulating production of thrombospondin‐1 by macrophages

Adenosine modulation of thrombospondin‐1 expression by macrophages stimulates angiogenesis. Increase of blood capillary density at the interface between normal and ischemic tissue after acute MI reduces infarct size and improves cardiac function. Cardiac injury triggers the production of the matrice...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 97; no. 1; pp. 9 - 18
Main Authors:	Ernens, Isabelle, Bousquenaud, Me´lanie, Lenoir, Be´ne´dicte, Devaux, Yvan, Wagner, Daniel R.
Format:	Journal Article
Language:	English
Published:	United States 01-01-2015
Subjects:	Adenosine - metabolism adenosine receptors Animals aortic ring cardiac repair Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Humans Macrophages - metabolism Male matrigel plug Microscopy, Confocal Myocardial Infarction - metabolism Neovascularization, Physiologic - physiology Rats Rats, Wistar Real-Time Polymerase Chain Reaction revascularization Thrombospondin 1 - biosynthesis Up-Regulation aortic ring revascularization cardiac repair matrigel plug adenosine receptors
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