Increased cerebellar volume and BDNF level following quadrato motor training

• Published in: Synapse (New York, N.Y.) Vol. 69; no. 1; pp. 1 - 6
• Main Authors: Ben-Soussan, Tal Dotan, Piervincenzi, Claudia, Venditti, Sabrina, Verdone, Loredana, Caserta, Micaela, Carducci, Filippo
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-01-2015; Wiley Subscription Services, Inc
• Subjects: Adult; Blotting, Western; brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; cerebellum; Cerebellum - anatomy & histology; Cerebellum - physiology; Diffusion Tensor Imaging; Electrophoresis, Polyacrylamide Gel; Female; Gray Matter - anatomy & histology; Gray Matter - physiology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Middle Aged; MRI; Neuronal Plasticity - physiology; neuroplasticity; Organ Size; Practice (Psychology); Psychomotor Performance - physiology; Saliva - metabolism; sensorimotor training; brain-derived neurotrophic factor; MRI; sensorimotor training; cerebellum; neuroplasticity
• ISSN: 0887-4476; 1098-2396
• DOI: 10.1002/syn.21787

Using whole‐brain structural measures coupled to analysis of salivary brain‐derived neurotrophic factor (BDNF), we demonstrate sensory motor training‐induced plasticity, including cerebellar gray matter volume increment and increased BDNF level. The increase of cerebellar volume was positively correlated with the increase of BDNF level.