Gene amplification of the transcription factor DP1 and CTNND1 in human lung cancer

The search for novel oncogenes is important because they could be the target of future specific anticancer therapies. In the present paper we report the identification of novel amplified genes in lung cancer by means of global gene expression analysis. To screen for amplicons, we aligned the gene ex...

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Bibliographic Details
Published in:	The Journal of pathology Vol. 222; no. 1; pp. 89 - 98
Main Authors:	Castillo, Sandra D., Angulo, Barbara, Suarez-Gauthier, Ana, Melchor, Lorenzo, Medina, Pedro P., Sanchez-Verde, Lydia, Torres-Lanzas, Juan, Pita, Guillermo, Benitez, Javier, Sanchez-Cespedes, Montse
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-09-2010 Wiley
Subjects:	Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Catenins - genetics Cell Survival - genetics chromosome 11 Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 13 - genetics Cluster Analysis copy number CTNND1 Data processing DNA microarrays DP1 protein E2F protein Fluorescence in situ hybridization Gene Amplification Gene Expression Regulation, Neoplastic Genes, Neoplasm Genomes genomics Humans Investigative techniques, diagnostic techniques (general aspects) Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical sciences Mutation Neoplasm Proteins - metabolism Non-small cell lung carcinoma oncogene Oncogenes Overexpression p120ctn Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pneumology Polymerase chain reaction RNA Interference RNA, Small Interfering - genetics RNA-mediated interference siRNA TFDP1 Transcription Factor DP1 - deficiency Transcription Factor DP1 - genetics Transcription Factor DP1 - metabolism Transcription factors Tumor cell lines Tumor Cells, Cultured Tumors Tumors of the respiratory system and mediastinum Human Lung disease Respiratory disease Lung cancer CTNND1 Malignant tumor oncogene Signal transduction p120ctn Gene amplification Anatomic pathology TFDP1 Bronchus disease Transcription factor Onc gene Cancer
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