C-Phycocyanin ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells

For decades Experimental Autoimmune Encephalitis (EAE) has remained as an unsurpassed multiple sclerosis (MS) animal model. C-Phycocyanin (C-Pc) has been reported to exhibit pharmacological properties that may be expected to symptomatically improve EAE and MS. However, in this paper we reveal a basi...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 11; no. 1; pp. 29 - 38
Main Authors:	Pentón-Rol, Giselle, Martínez-Sánchez, Gregorio, Cervantes-Llanos, Majel, Lagumersindez-Denis, Nielsen, Acosta-Medina, Emilio Felino, Falcón-Cama, Viviana, Alonso-Ramírez, Ruby, Valenzuela-Silva, Carmen, Rodríguez-Jiménez, Efraín, Llópiz-Arzuaga, Alexey, Marín-Prida, Javier, López-Saura, Pedro Antonio, Guillén-Nieto, Gerardo Emilio, Pentón-Arias, Eduardo
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier B.V 2011 Elsevier
Subjects:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Antioxidants - administration & dosage Antioxidants - isolation & purification Antioxidants - therapeutic use Biological and medical sciences Biomarkers - analysis Biomarkers - blood Brain - immunology Brain - metabolism Brain - ultrastructure Cells, Cultured Central nervous system Cyanobacteria - chemistry Demyelination Encephalomyelitis, Autoimmune, Experimental - blood Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - prevention & control Flow Cytometry Humans Hydrocortisone - administration & dosage Hydrocortisone - therapeutic use Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lipid Peroxidation - drug effects Male Medical sciences Microscopy, Electron, Transmission Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurodegenerative disorder Neurology Oxidation-Reduction Pharmacology. Drug treatments Phycocyanin - administration & dosage Phycocyanin - isolation & purification Phycocyanin - therapeutic use Rats Rats, Inbred Lew Regulatory T cells Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Neurodegenerative disorder Multiple sclerosis Regulatory T cells Demyelination Central nervous system Autoimmunity Animal model Nervous system diseases Experimental allergic encephalomyelitis Inflammatory disease Central nervous system disease T-Lymphocyte Regulatory cell
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