Transplantation of an eight-organ multivisceral graft in a patient with frozen abdomen after complicated Crohn's disease

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 27; pp. 4431 - 4434
• Main Authors: Pascher, Andreas, Klupp, Jochen, Kohler, Sven, Langrehr, Jan-M, Neuhaus, Peter
• Format: Journal Article
• Language: English
• Published: United States Department of Visceral and Transplantation Surgery,Charité - Universitatsmedizin Berlin, Campus Virchow Klinikum,Augustenburgerplatz 1, Berlin 13353, Germany%Exploratory Clinical Development, Novartis Pharma AG, WSJ-103.4.26, CH-4002 Basel, Switzerland 21-07-2006; Baishideng Publishing Group Co., Limited
• Subjects: Adrenal Glands - transplantation; Adult; Case Report; Colon - transplantation; Crohn Disease - complications; Duodenum - transplantation; Female; Humans; Kidney Transplantation; Liver Transplantation; Multiple Organ Failure - etiology; Multiple Organ Failure - surgery; Omentum - transplantation; Organ Transplantation - methods; Pancreas Transplantation; Stomach - transplantation; Treatment Outcome; Crohn's disease; Intestinal transplantation; Multivisceral transplantation
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i27.4431

To report an extended multivisceral transplantation (MVTx) including right kidney and ascending colon in a patient with complicated Crohn's disease (CD). A 36-year old female suffering from short bowel syndrome and frozen abdomen due to fistulizing CD after multiple abdominal operations underwent MVTx of eight organs including stomach, pancreatoduodenal complex, liver, intestine, ascending colon, right kidney, right adrenal gland, and greater omentum in November 2003. Immunosuppression consisted of alemtuzumab, tacrolimus and steroids. The patient was off parenteral nutrition by postoperative wk 3. She experienced one episode of pneumonia. The patient recovered completely and discharged 2.5 mo and was doing well 30 mo after MVTx. This is one of the very rare cases in which a complete mulitivisceral graft of eight abdominal organs was transplanted orthotopically.