Determination of phenylalanine and tyrosine in plasma and dried blood samples using HPLC with fluorescence detection

The determination of phenylalanine and tyrosine is presently the most reliable direct approach to the diagnosis of phenylketonuria. An HPLC method for the simultaneous measurement of phenylalanine and tyrosine in samples of dried blood spots and plasma has been developed and evaluated. We have used...

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Bibliographic Details
Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 877; no. 30; pp. 3926 - 3929
Main Authors:	KAND'AR, Roman, ZAKOVA, Pavla
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 15-11-2009 Elsevier
Subjects:	Adult Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Dried blood spots Female Fluorescence Fluorescence detection Fundamental and applied biological sciences. Psychology General pharmacology HPLC Humans Male Medical sciences Middle Aged N-Methylphenylalanine Pharmacology. Drug treatments Phenylalanine Phenylalanine - blood Phenylketonuria Tyrosine Tyrosine - blood Tyrosine Phenylketonuria Phenylalanine Dried blood spots N-Methylphenylalanine HPLC Fluorescence detection Biological fluid Nervous system diseases Fluorescence detector HPLC chromatography Metabolic diseases Determination Enzymopathy Blood Genetic disease Blood plasma α-Aminoacid Aminoacid Aminoacid disorder Quantitative analysis
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