The use of adeno-associated virus to circumvent the maturation-dependent viral transduction of muscle fibers

Muscle-based gene therapy using adenovirus, retrovirus, and herpes simplex virus has been hindered by viral cytotoxicity, host immune response, and the maturation-dependent viral transduction of muscle fibers. The development of new mutant vectors has greatly reduced the toxicity and the immune reje...

Full description

Bibliographic Details

Published in:	Human gene therapy Vol. 11; no. 4; p. 521
Main Authors:	Pruchnic, R, Cao, B, Peterson, Z Q, Xiao, X, Li, J, Samulski, R J, Epperly, M, Huard, J
Format:	Journal Article
Language:	English
Published:	United States 01-03-2000
Subjects:	Animals Dependovirus - genetics Genes, Reporter Genetic Therapy Genetic Vectors Heparan Sulfate Proteoglycans - metabolism Immunohistochemistry Lac Operon Mice Mice, Inbred C57BL Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Transduction, Genetic
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!