Pharmacokinetic evaluation of platinum derived from cisplatin administered alone and with pemetrexed in head and neck cancer patients

Purpose This phase I study characterized the pharmacokinetics of free and total platinum derived from cisplatin administered alone and in combination with pemetrexed. Secondary objectives were to assess the pharmacokinetics of pemetrexed when it is combined with cisplatin as well as to evaluate the...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 64; no. 2; pp. 233 - 241
Main Authors:	Specenier, Pol M, Ciuleanu, Tudor, Latz, Jane E, Musib, Luna C, Darstein, Christelle L. S, Vermorken, Jan B
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01-07-2009 Springer-Verlag Springer Springer Nature B.V
Subjects:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Area Under Curve Biological and medical sciences Cancer Research Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - pathology Cisplatin - administration & dosage Cross-Over Studies Dietary Supplements Female Glutamates - administration & dosage Guanine - administration & dosage Guanine - analogs & derivatives Head and Neck Neoplasms - blood Head and Neck Neoplasms - pathology Humans Male Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Staging Oncology Original Article Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pemetrexed Pharmacology. Drug treatments Pharmacology/Toxicology Platinum - blood Prognosis Treatment Outcome Tumors Head and neck cancer Pharmacokinetics Platinum Pemetrexed Cisplatin Antineoplastic agent Human Evaluation Patient Malignant tumor Antifolate Alkylating agent ENT disease Cancer Platinum II Complexes
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