Stimulation of prostaglandin output from rat stomach by hypertonic solutions

A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhance...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 44; no. 3; p. 271
Main Authors:	Assouline, G, Leibson, V, Danon, A
Format:	Journal Article
Language:	English
Published:	Netherlands 01-08-1977
Subjects:	Animals Female Gastric Mucosa - metabolism Hypertonic Solutions - pharmacology In Vitro Techniques Mannitol - pharmacology Prostaglandins E - metabolism Rats Sodium Chloride - pharmacology Stimulation, Chemical Stomach - drug effects Time Factors Urea - pharmacology
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Summary:	A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline--hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.
ISSN:	0014-2999
DOI:	10.1016/0014-2999(77)90073-5