Quantitative structural analysis of glycans expressed within tumors derived from pancreatic cancer patient-derived xenograft mouse models

Pancreatic ductal adenocarcinoma (PDAC) is an intractable malignancy for which novel therapeutic targets are in high demand. To uncover glycans expressed within PDAC, we previously performed glycome profiling of PDAC cell lines using lectin microarray and found that the lectin rBC2LCN with specifici...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 534; pp. 310 - 316
Main Authors:	Hasehira, Kayo, Furuta, Tomoaki, Shimomura, Osamu, Asada, Masahiro, Oda, Tatsuya, Tateno, Hiroaki
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-01-2021
Subjects:	Animals Carbohydrate Conformation Carbohydrate Sequence Carcinoma, Pancreatic Ductal - chemistry Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Differentiation Cell Line, Tumor Female Fucose Glycan Glycomics H-type3 Heterografts Humans Mice Mice, SCID Molecular Structure Neoplasm Transplantation Pancreatic cancer Pancreatic Neoplasms - chemistry Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Polysaccharides - chemistry Polysaccharides - metabolism rBC2LCN MPC PDX hPSC LDC LAPC Glycan LC50 PA H-type3 PDAC Pancreatic cancer rBC2LCN Fucose
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