Insulin resistance in HIV-infected patients: relationship with pro-inflammatory cytokines released by peripheral leukocytes

Objectives. Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-α and IL-1β) can induce insulin resistance in infections, we investigated the relationship between insulin sensitivity and cytokine release from peripheral blood...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of infection Vol. 47; no. 1; pp. 52 - 58
Main Authors:	Limone, Paolo, Biglino, Alberto, Valle, Mauro, Degioanni, Maria, Paola Servato, Maria, Berardi, Clara, Del Rizzo, Paola, Pellissetto, Cristina, Carlo Isaia, Giovanni
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01-07-2003 Elsevier
Subjects:	Adult Biological and medical sciences Blood Glucose - analysis cytokines HIV infection HIV Infections - blood HIV Infections - physiopathology Human viral diseases Humans Hydrocortisone - blood Infectious diseases Insulin - blood insulin resistance Insulin Resistance - physiology Interleukin-1 - blood Male Medical sciences Tumor Necrosis Factor-alpha - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids HIV infection insulin resistance cytokines Infection Human Immunopathology Target tissue resistance Leukocyte Pathogenesis Viral disease Cytokine AIDS Immune deficiency Insulin
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Objectives. Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-α and IL-1β) can induce insulin resistance in infections, we investigated the relationship between insulin sensitivity and cytokine release from peripheral blood mononuclear cells (PBMCs) in HIV-infected patients. Methods. Fourteen HIV-positive patients treated with dual-NRTI (nucleosidic reverse transcriptase inhibitors) regimens, and fourteen healthy controls were studied. Insulin resistance was assessed by homeostatic model for insulin resistance (HOMA-IR). Cytokine production by PBMCs ex vivo was measured. Results. Plasma glucose levels did not differ in HIV patients and in controls. Insulin concentrations and HOMA-IR were significantly higher in HIV-infected patients than in controls (respectively, 11.4±4.3 vs. 7.86±1.1 mIU, P=0.005; 2.27±0.91 vs. 1.6±0.2, P=0.025). A significant positive linear correlation was observed between HOMA-IR and TNF-α concentrations in the supernatants of unstimulated PBMC cultures in HIV patients ( r=0.771; P=0.001 ), but not in controls. Conclusions. Our results are in accordance with previous findings showing that insulin resistance may indeed be present in PI-naive HIV patients, and suggest that either TNF-α, or other mediators released in parallel with this cytokine may induce a state of insulin resistance, unrelated to highly active antiviral treatments, in poorly controlled HIV disease.
AbstractList	OBJECTIVESAbnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-alpha and IL-1beta) can induce insulin resistance in infections, we investigated the relationship between insulin sensitivity and cytokine release from peripheral blood mononuclear cells (PBMCs) in HIV-infected patients. METHODSFourteen HIV-positive patients treated with dual-NRTI (nucleosidic reverse transcriptase inhibitors) regimens, and fourteen healthy controls were studied. Insulin resistance was assessed by homeostatic model for insulin resistance (HOMA-IR). Cytokine production by PBMCs ex vivo was measured. RESULTSPlasma glucose levels did not differ in HIV patients and in controls. Insulin concentrations and HOMA-IR were significantly higher in HIV-infected patients than in controls (respectively, 11.4+/-4.3 vs. 7.86+/-1.1mIU, P=0.005; 2.27+/-0.91 vs. 1.6+/-0.2, P=0.025). A significant positive linear correlation was observed between HOMA-IR and TNF-alpha concentrations in the supernatants of unstimulated PBMC cultures in HIV patients (r=0.771;P=0.001), but not in controls. CONCLUSIONSOur results are in accordance with previous findings showing that insulin resistance may indeed be present in PI-naive HIV patients, and suggest that either TNF-alpha, or other mediators released in parallel with this cytokine may induce a state of insulin resistance, unrelated to highly active antiviral treatments, in poorly controlled HIV disease. Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-alpha and IL-1beta) can induce insulin resistance in infections, we investigated the relationship between insulin sensitivity and cytokine release from peripheral blood mononuclear cells (PBMCs) in HIV-infected patients. Fourteen HIV-positive patients treated with dual-NRTI (nucleosidic reverse transcriptase inhibitors) regimens, and fourteen healthy controls were studied. Insulin resistance was assessed by homeostatic model for insulin resistance (HOMA-IR). Cytokine production by PBMCs ex vivo was measured. Plasma glucose levels did not differ in HIV patients and in controls. Insulin concentrations and HOMA-IR were significantly higher in HIV-infected patients than in controls (respectively, 11.4+/-4.3 vs. 7.86+/-1.1mIU, P=0.005; 2.27+/-0.91 vs. 1.6+/-0.2, P=0.025). A significant positive linear correlation was observed between HOMA-IR and TNF-alpha concentrations in the supernatants of unstimulated PBMC cultures in HIV patients (r=0.771;P=0.001), but not in controls. Our results are in accordance with previous findings showing that insulin resistance may indeed be present in PI-naive HIV patients, and suggest that either TNF-alpha, or other mediators released in parallel with this cytokine may induce a state of insulin resistance, unrelated to highly active antiviral treatments, in poorly controlled HIV disease. Objectives. Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-[alpha] and IL-1[beta]) can induce insulin resistance in infections, we investigated the relationship between insulin sensitivity and cytokine release from peripheral blood mononuclear cells (PBMCs) in HIV-infected patients. Methods. Fourteen HIV-positive patients treated with dual-NRTI (nucleosidic reverse transcriptase inhibitors) regimens, and fourteen healthy controls were studied. Insulin resistance was assessed by homeostatic model for insulin resistance (HOMA-IR). Cytokine production by PBMCs ex vivo was measured. Results. Plasma glucose levels did not differ in HIV patients and in controls. Insulin concentrations and HOMA-IR were significantly higher in HIV-infected patients than in controls (respectively, 11.4+/-4.3 vs. 7.86+/-1.1 mIU, P=0.005; 2.27+/-0.91 vs. 1.6+/-0.2, P=0.025). A significant positive linear correlation was observed between HOMA-IR and TNF-[alpha] concentrations in the supernatants of unstimulated PBMC cultures in HIV patients (r=0.771; P=0.001), but not in controls. Conclusions. Our results are in accordance with previous findings showing that insulin resistance may indeed be present in PI-naive HIV patients, and suggest that either TNF-[alpha], or other mediators released in parallel with this cytokine may induce a state of insulin resistance, unrelated to highly active antiviral treatments, in poorly controlled HIV disease. Objectives. Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-α and IL-1β) can induce insulin resistance in infections, we investigated the relationship between insulin sensitivity and cytokine release from peripheral blood mononuclear cells (PBMCs) in HIV-infected patients. Methods. Fourteen HIV-positive patients treated with dual-NRTI (nucleosidic reverse transcriptase inhibitors) regimens, and fourteen healthy controls were studied. Insulin resistance was assessed by homeostatic model for insulin resistance (HOMA-IR). Cytokine production by PBMCs ex vivo was measured. Results. Plasma glucose levels did not differ in HIV patients and in controls. Insulin concentrations and HOMA-IR were significantly higher in HIV-infected patients than in controls (respectively, 11.4±4.3 vs. 7.86±1.1 mIU, P=0.005; 2.27±0.91 vs. 1.6±0.2, P=0.025). A significant positive linear correlation was observed between HOMA-IR and TNF-α concentrations in the supernatants of unstimulated PBMC cultures in HIV patients ( r=0.771; P=0.001 ), but not in controls. Conclusions. Our results are in accordance with previous findings showing that insulin resistance may indeed be present in PI-naive HIV patients, and suggest that either TNF-α, or other mediators released in parallel with this cytokine may induce a state of insulin resistance, unrelated to highly active antiviral treatments, in poorly controlled HIV disease.
Author	Berardi, Clara Carlo Isaia, Giovanni Paola Servato, Maria Biglino, Alberto Del Rizzo, Paola Pellissetto, Cristina Limone, Paolo Valle, Mauro Degioanni, Maria
Author_xml	– sequence: 1 givenname: Paolo surname: Limone fullname: Limone, Paolo organization: Department of Internal Medicine, University of Torino, Torino, Italy – sequence: 2 givenname: Alberto surname: Biglino fullname: Biglino, Alberto email: biglino@asl19.asti.it organization: Infectious Diseases Unit, Civil Hospital of Asti, Via Botallo 4, 14100 Asti, Italy – sequence: 3 givenname: Mauro surname: Valle fullname: Valle, Mauro organization: Infectious Diseases Unit, Civil Hospital of Asti, Via Botallo 4, 14100 Asti, Italy – sequence: 4 givenname: Maria surname: Degioanni fullname: Degioanni, Maria organization: Infectious Diseases Unit, Civil Hospital of Asti, Via Botallo 4, 14100 Asti, Italy – sequence: 5 givenname: Maria surname: Paola Servato fullname: Paola Servato, Maria organization: Infectious Diseases Unit, Civil Hospital of Asti, Via Botallo 4, 14100 Asti, Italy – sequence: 6 givenname: Clara surname: Berardi fullname: Berardi, Clara organization: Department of Internal Medicine, University of Torino, Torino, Italy – sequence: 7 givenname: Paola surname: Del Rizzo fullname: Del Rizzo, Paola organization: Department of Internal Medicine, University of Torino, Torino, Italy – sequence: 8 givenname: Cristina surname: Pellissetto fullname: Pellissetto, Cristina organization: Department of Internal Medicine, University of Torino, Torino, Italy – sequence: 9 givenname: Giovanni surname: Carlo Isaia fullname: Carlo Isaia, Giovanni organization: Department of Internal Medicine, University of Torino, Torino, Italy
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15048646$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12850163$$D View this record in MEDLINE/PubMed
BookMark	eNqFkV2L1DAUhoOsuLOrP0HpjaIX1dN8deqNyKLuwIIXftyGND1l4rZpzUmVwT9v6gzu5ULIB3ne5HCeC3YWpoCMPa3gdQWVfvMlT6KUUomXIF4BgFIlPGCbSgle8lryM7b5j5yzC6IfGWpEox-x84pv1Xq5YX92gZbBhyIieUo2OCzy6Xr3vfShR5ewK2abPIZEbzM05P0UaO_n4rdP-2KO0woOdhxtmuKhcIc03fqAtMJoKefbQzFj9PMeox2KAZfbKVNIj9nD3g6ET07rJfv28cPXq-vy5vOn3dX7m9JJzlNpUXOrOVgFLbbgFDgtq8Yq7WorRN22ruuUtFw3vEMJFjioWghUde_6TolL9uL4bi7254KUzOjJ4TDYgNNCphZSg1DNvWC13ULNJWRQHUEXJ6KIvZmjH208mArMqsf802PW3hvIY9Vj1tyz0wdLO2J3lzr5yMDzE2DJ2aGPWYinO06B3GqpM_fuyGHu2y-P0ZDLjhx2PmZpppv8PaX8BQWTsHE
CODEN	JINFD2
CitedBy_id	crossref_primary_10_1179_acb_2008_042 crossref_primary_10_1016_j_beem_2011_04_003 crossref_primary_10_1086_503573 crossref_primary_10_1371_journal_pone_0197080 crossref_primary_10_1007_s12020_011_9565_z crossref_primary_10_1111_j_1745_7599_2006_00109_x crossref_primary_10_1530_EJE_14_0337 crossref_primary_10_1016_j_cytogfr_2016_01_001 crossref_primary_10_1007_s40121_018_0229_7 crossref_primary_10_3390_life14060742 crossref_primary_10_1097_QAI_0b013e31829f919d crossref_primary_10_1016_j_metabol_2005_08_018 crossref_primary_10_1371_journal_pone_0090330
ContentType	Journal Article
Copyright	2003 The British Infection Society 2003 INIST-CNRS
Copyright_xml	– notice: 2003 The British Infection Society – notice: 2003 INIST-CNRS
DBID	IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U9 H94 7X8
DOI	10.1016/S0163-4453(03)00055-0
DatabaseName	Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Virology and AIDS Abstracts MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Public Health
EISSN	1532-2742
EndPage	58
ExternalDocumentID	10_1016_S0163_4453_03_00055_0 12850163 15048646 S0163445303000550
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --M .1- .FO .GJ .~1 0R~ 0SF 1B1 1P~ 1RT 1~. 1~5 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAWTL AAXUO ABBQC ABFNM ABFRF ABJNI ABLVK ABMAC ABMZM ABXDB ABYKQ ACDAQ ACGFO ACGFS ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGEKW AGHFR AGUBO AGYEJ AHHHB AI. AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG CJTIS COF CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEJ HMK HMO HVGLF HZ~ IHE J1W J5H KOM L7B LCYCR LUGTX M27 M41 MO0 N9A O-L O9- OAUVE OD- OO. OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SDF SDG SDP SEL SES SEW SPCBC SSH SSI SSZ T5K UHS VH1 WUQ YHZ Z5R ZGI ~G- ABPIF IQODW K-O AAXKI ADVLN AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U9 H94 7X8
ID	FETCH-LOGICAL-c422t-ae62a620a50beb0c50c6419a56c7a337bbcdd54a2692de40a0205733e57fcfd53
ISSN	0163-4453
IngestDate	Fri Oct 25 05:51:37 EDT 2024 Sat Oct 05 06:21:04 EDT 2024 Thu Nov 21 21:47:04 EST 2024 Sat Sep 28 08:39:31 EDT 2024 Sun Oct 22 16:09:36 EDT 2023 Fri Feb 23 02:16:27 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	HIV infection insulin resistance cytokines Infection Human Immunopathology Target tissue resistance Leukocyte Pathogenesis Viral disease Cytokine AIDS Immune deficiency Insulin
Language	English
License	CC BY 4.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c422t-ae62a620a50beb0c50c6419a56c7a337bbcdd54a2692de40a0205733e57fcfd53
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
PMID	12850163
PQID	18807240
PQPubID	23462
PageCount	7
ParticipantIDs	proquest_miscellaneous_73460359 proquest_miscellaneous_18807240 crossref_primary_10_1016_S0163_4453_03_00055_0 pubmed_primary_12850163 pascalfrancis_primary_15048646 elsevier_sciencedirect_doi_10_1016_S0163_4453_03_00055_0
PublicationCentury	2000
PublicationDate	2003-07-01
PublicationDateYYYYMMDD	2003-07-01
PublicationDate_xml	– month: 07 year: 2003 text: 2003-07-01 day: 01
PublicationDecade	2000
PublicationPlace	Kidlington
PublicationPlace_xml	– name: Kidlington – name: England
PublicationTitle	The Journal of infection
PublicationTitleAlternate	J Infect
PublicationYear	2003
Publisher	Elsevier Ltd Elsevier
Publisher_xml	– name: Elsevier Ltd – name: Elsevier
References	Heyligenberg, Romijn, Hommes, Endert, Eeftinck Schattenkerk, Sauerwein (BIB11) 1993; 84 Agwunobi, Reid, Mayocock, Little, Carlson (BIB27) 2000; 85 Poccia, Wallace, Colizzi, Malkowsky (BIB44) 1998; 1 Yki-Jarvinen, Sammalkorpi, Koivisto, Nikkila (BIB16) 1989; 69 Lichtenstein, Ward, Moorman, Delaney, Young, Palella, Rhodes, Wood, Holmberg (BIB21) 2001; 15 Mynarcik, McNurlan, Steigbigel, Fuhrer, Gelato (BIB39) 2000; 25 Hadigan, Meigs, Corcoran (BIB10) 2001; 32 Lang, Dobrescu, Bagby (BIB37) 1992; 130 Wasmuth, Hess, Viergutz, Henrichs, Martin, Kolb (BIB26) 2000; 16 Stephens, Pilch (BIB34) 1995; 16 Hotamisligil, Peraldi, Budavari, Ellis, White, Spiegelman (BIB32) 1996; 271 Sellmeyer, Grunfeld (BIB6) 1996; 17 Mizcok (BIB25) 1995; 98 Hellerstein, Grunfeld, Wu, Christiansen, Kaempfer, Kletke (BIB38) 1993; 76 Sthephens, Pekala (BIB36) 1991; 266 Safrin, Grunfeld (BIB4) 1999; 13 Cheung, Ree, Kolls, Fuselier, Coy, Bryer-Ash (BIB31) 1998; 139 deBont, Niemarkt, Tamminga, Kimpen, Kamps, de Leij (BIB24) 1996; 106 Hadigan, Miller, Corcoran, Anderson, Basgoz, Grinspoon (BIB7) 1999; 84 Ullum, Victor, Katzenstein, Gerstoft, Gotzsche, Bendtzen (BIB40) 1997; 175 Walli, Herfort, Michl (BIB5) 1998; 12 Dube, Edmondson-Melancon, Qian, Johnson, Buchanan (BIB30) 2001; 27 Piccinini, Rinaudo, Chiapello, Ricotti, Baldovino, Mostert, Tovo (BIB46) 2002; 16 Rizzardi, Marriott, Cookson, Lazzarin, Dalgleish, Barcellini (BIB20) 1998; 114 Graham (BIB1) 2000; 25 Poli (BIB19) 1999; 29 Matthews, Hosker, Rudenski, Naylor, Treacher, Turner (BIB22) 1985; 28 Abad, Schmitz, Parker, Roubenoff (BIB42) 2002; 18 Hadigan, Corcoran, Stanley, Piecuch, Klibanski, Grinspoon (BIB8) 2000; 85 Virkamaki, Puhakainen, Koivisto, Vuorinen-Markkola, Yki-Jarvinen (BIB15) 1992; 74 Mayringer, Reindl, Berger (BIB41) 2000; 235 Hommes, Romijn, Endert, Schattenkerk, Sauerwein (BIB12) 1991; 40 Hotamisligil, Shargill, Spiegelman (BIB13) 1993; 259 Petit, Duong, Duvillard, Piroth, Grappin, Verges (BIB29) 2000; 32 Hotamisligil, Murray, Choy, Spiegelman (BIB33) 1994; 91 Feinstein, Kanety, Papa, Lunenfeld, Karisik (BIB35) 1993; 268 Ledru, Christeff, Patey, de Truchis, Melchior, Gougeon (BIB47) 2000; 95 Tovo (BIB45) 2000; 14 Carr, Samaras, Chisholm, Cooper (BIB3) 1998; 352 van der Poll, Romijn, Endert, Borm, Buller, Sauerwein (BIB18) 1991; 261 Dube (BIB2) 2000; 31 Festa, D'Agostino, Howard, Mykkanen, Tracy, Haffner (BIB28) 2000; 102 Mulligan, Grunfeld, Tai (BIB9) 2000; 23 Benyoucef, Hober, Shen, Ajana, De Groote, Bocket-Mou, Gerard, Lion, Vilain, Wattre (BIB43) 1997; 41 Hotamisligil, Spiegelman (BIB14) 1994; 43 Grunfeld, Feingold (BIB17) 1991; 3 Haffner, Gonzalez, Miettinen, Kennedy, Stern (BIB23) 1999; 19
References_xml	– volume: 98 start-page: 75 year: 1995 end-page: 84 ident: BIB25 article-title: Alteration in carbohydrate metabolism during stress: a review of literature publication-title: Am J Med contributor: fullname: Mizcok – volume: 32 start-page: 130 year: 2001 end-page: 139 ident: BIB10 article-title: Metabolic abnormalities and cardiovascular disease risk factor in adults with human immunodeficiency virus infection and lipodystrophy publication-title: Clin Infect Dis contributor: fullname: Corcoran – volume: 271 start-page: 665 year: 1996 end-page: 668 ident: BIB32 article-title: IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in (TNF-α)-and obesity-induced insulin resistance publication-title: Science contributor: fullname: Spiegelman – volume: 41 start-page: 939 year: 1997 end-page: 946 ident: BIB43 article-title: Production of TNF-alpha and IL-6 by activated whole blood of HIV-1 infected patients detected by a one-stage procedure: relationship with the phenotype of HIV-1 isolates publication-title: Microbiol Immunol contributor: fullname: Wattre – volume: 31 start-page: 1467 year: 2000 end-page: 1475 ident: BIB2 article-title: Disorders of glucose metabolism in patients infected with human immunodeficiency virus publication-title: Clin Infect Dis contributor: fullname: Dube – volume: 74 start-page: 673 year: 1992 end-page: 679 ident: BIB15 article-title: Mechanisms of hepatic and peripheral insulin resistance during acute infections in humans publication-title: J Clin Endocrinol Metab contributor: fullname: Yki-Jarvinen – volume: 91 start-page: 4854 year: 1994 end-page: 4858 ident: BIB33 article-title: Tumor Necrosis Factor α inhibits signaling from the insulin receptor publication-title: Proc Natl Acad Sci contributor: fullname: Spiegelman – volume: 1 start-page: 409 year: 1998 end-page: 413 ident: BIB44 article-title: Possible protective and pathogenic roles of gamma delta T-lymphocytes in HIV infections publication-title: Int J Mol Med contributor: fullname: Malkowsky – volume: 14 start-page: 743 year: 2000 end-page: 744 ident: BIB45 article-title: Highly active antiretroviral therapy inhibits cytokine production in HIV uninfected subjects publication-title: AIDS contributor: fullname: Tovo – volume: 15 start-page: 1389 year: 2001 end-page: 1398 ident: BIB21 article-title: Clinical assessment of HIV-associated lipodystrophy in an ambulatory population publication-title: AIDS contributor: fullname: Holmberg – volume: 352 start-page: 1881 year: 1998 end-page: 1883 ident: BIB3 article-title: Pathogenesis of HIV-1-protease inhibitor associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance publication-title: Lancet contributor: fullname: Cooper – volume: 130 start-page: 43 year: 1992 end-page: 52 ident: BIB37 article-title: Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output publication-title: Endocrinology contributor: fullname: Bagby – volume: 12 start-page: F167 year: 1998 end-page: F173 ident: BIB5 article-title: Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients publication-title: AIDS contributor: fullname: Michl – volume: 19 start-page: 1138 year: 1999 end-page: 1142 ident: BIB23 article-title: A prospective analysis of the HOMA model: the Mexico City diabetes study publication-title: Diabetes Care contributor: fullname: Stern – volume: 106 start-page: 593 year: 1996 end-page: 598 ident: BIB24 article-title: Lipopolysaccharide-induced cytokine production in peripheral blood mononuclear cells: intracellular localization of tumor necrosis factor alpha and interleukin-1-beta detected with a three-color immunofluorescence technique publication-title: Histochem Cell Biol contributor: fullname: de Leij – volume: 266 start-page: 21839 year: 1991 end-page: 21845 ident: BIB36 article-title: Transcriptional repression of GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alfa publication-title: J Biol Chem contributor: fullname: Pekala – volume: 16 start-page: 529 year: 1995 end-page: 546 ident: BIB34 article-title: The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter publication-title: Endocr Rev contributor: fullname: Pilch – volume: 17 start-page: 518 year: 1996 end-page: 532 ident: BIB6 article-title: Endocrine and metabolic disturbances in human immunodeficiency virus infection and the acquired immune deficiency syndrome publication-title: Endocr Rev contributor: fullname: Grunfeld – volume: 16 start-page: 177 year: 2000 end-page: 178 ident: BIB26 article-title: Non-specific viral infections as possible synchronising events of the manifestation of type I diabetes publication-title: Diabetes Metab Res Rev contributor: fullname: Kolb – volume: 139 start-page: 4928 year: 1998 end-page: 4935 ident: BIB31 article-title: An in vivo model for elucidation of the mechanism of Tumor Necrosis Factor-(TNF-α)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-α publication-title: Endocrinology contributor: fullname: Bryer-Ash – volume: 268 start-page: 26055 year: 1993 end-page: 26058 ident: BIB35 article-title: Tumor necrosis factor-α suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates publication-title: J Biol Chem contributor: fullname: Karisik – volume: 84 start-page: 1932 year: 1999 end-page: 1937 ident: BIB7 article-title: Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women publication-title: J Clin Endocrinol Metab contributor: fullname: Grinspoon – volume: 25 start-page: 312 year: 2000 end-page: 321 ident: BIB39 article-title: Association of severe insulin resistance with both loss of limb fat and elevated serum Tumor Necrosis Factor receptor levels in HIV lipodystrophy publication-title: J Acquir Immune Defic Syndr contributor: fullname: Gelato – volume: 40 start-page: 651 year: 1991 end-page: 656 ident: BIB12 article-title: Insulin sensitivity and insulin clearance in human immunodeficiency virus-infected men publication-title: Metabolism contributor: fullname: Sauerwein – volume: 84 start-page: 209 year: 1993 end-page: 216 ident: BIB11 article-title: Non-insulin-mediated glucose uptake in human immunodeficiency virus-infected men publication-title: Clin Sci contributor: fullname: Sauerwein – volume: 13 start-page: 2493 year: 1999 end-page: 2505 ident: BIB4 article-title: Fat distribution and metabolic changes in patients with HIV infection publication-title: AIDS contributor: fullname: Grunfeld – volume: 3 start-page: 143 year: 1991 end-page: 158 ident: BIB17 article-title: The metabolic effects of tumor necrosis factor and other cytokines publication-title: Biotheraphy contributor: fullname: Feingold – volume: 76 start-page: 559 year: 1993 end-page: 565 ident: BIB38 article-title: Increased de novo hepatic lipogenesis in human immunodeficiency virus infection publication-title: J Clin Endocrinol Metab contributor: fullname: Kletke – volume: 69 start-page: 317 year: 1989 end-page: 323 ident: BIB16 article-title: Severity, duration, and mechanisms of insulin resistance during acute infections publication-title: J Clin Endocrinol Metab contributor: fullname: Nikkila – volume: 261 start-page: E457 year: 1991 end-page: E465 ident: BIB18 article-title: Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans publication-title: Am J Physiol contributor: fullname: Sauerwein – volume: 25 start-page: 4 year: 2000 end-page: 11 ident: BIB1 article-title: Metabolic disorders among HIV-infected patients treated with protease inhibitors: a review publication-title: J Acquir Immune Defic Syndr contributor: fullname: Graham – volume: 114 start-page: 61 year: 1998 end-page: 65 ident: BIB20 article-title: Tumor necrosis factor (TNF) and TNF-related molecules in HIV-1+ individuals; relationship with in vitro Th1/Th2-type response publication-title: Clin Exp Immunol contributor: fullname: Barcellini – volume: 43 start-page: 1271 year: 1994 end-page: 1278 ident: BIB14 article-title: Tumor Necrosis Factor-α: a key component of the obesity-diabetes link publication-title: Diabetes contributor: fullname: Spiegelman – volume: 23 start-page: 35 year: 2000 end-page: 43 ident: BIB9 article-title: Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection publication-title: J Acquir Immune Defic Syndr Hum Retrovirol contributor: fullname: Tai – volume: 259 start-page: 87 year: 1993 end-page: 91 ident: BIB13 article-title: Adipose expression of Tumor Necrosis Factor-α: direct role in obesity-linked insulin resistance publication-title: Science contributor: fullname: Spiegelman – volume: 16 start-page: 693 year: 2002 end-page: 700 ident: BIB46 article-title: The human 26S proteasome is a target of antiretroviral agents publication-title: AIDS contributor: fullname: Tovo – volume: 175 start-page: 1507 year: 1997 end-page: 1510 ident: BIB40 article-title: Decreased short-term production of Tumor Necrosis Factor-α and Interleukin-1 β in Human Immunodeficiency Virus-seropositive subjects publication-title: J Infect Dis contributor: fullname: Bendtzen – volume: 85 start-page: 3770 year: 2000 end-page: 3778 ident: BIB27 article-title: Insulin resistance and substrate utilization in human endotoxemia publication-title: J Clin Endocrinol Metab contributor: fullname: Carlson – volume: 32 start-page: 367 year: 2000 end-page: 372 ident: BIB29 article-title: HIV-1 protease inhibitors induce an increase of triglyceride level in HIV-infected men without modification of insulin sensitivity: a longitudinal study publication-title: Horm Metab Res contributor: fullname: Verges – volume: 102 start-page: 42 year: 2000 end-page: 47 ident: BIB28 article-title: Chronic subclinical inflammation as part of the insulin resistance syndrome: the insulin resistance atherosclerosis study publication-title: Circulation contributor: fullname: Haffner – volume: 18 start-page: 286 year: 2002 end-page: 293 ident: BIB42 article-title: Cytokine response differ by compartment and wasting status in patients with HIV infection and healthy controls publication-title: Cytokine contributor: fullname: Roubenoff – volume: 85 start-page: 35 year: 2000 end-page: 41 ident: BIB8 article-title: Fating hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use publication-title: J Clin Endocrinol Metab contributor: fullname: Grinspoon – volume: 235 start-page: 33 year: 2000 end-page: 40 ident: BIB41 article-title: A critical comparison of frequently used methods for the analysis of tumor necrosis factor-alpha expression by human immune cells publication-title: J Immunol Meth contributor: fullname: Berger – volume: 29 start-page: 723 year: 1999 end-page: 732 ident: BIB19 article-title: Cytokines and the human immunodeficiency virus: from bench to bedside publication-title: Eur J Clin Invest contributor: fullname: Poli – volume: 28 start-page: 412 year: 1985 end-page: 419 ident: BIB22 article-title: Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia contributor: fullname: Turner – volume: 27 start-page: 130 year: 2001 end-page: 134 ident: BIB30 article-title: Prospective evaluation of the effect of initiating indanavir-based therapy on insulin sensitivity and B-cell function in HIV-infected patients publication-title: J Acquir Immune Defic Syndr contributor: fullname: Buchanan – volume: 95 start-page: 3191 year: 2000 end-page: 3198 ident: BIB47 article-title: Alteration of tumor necrosis factor-α T-cell homeostasis following potent antiretroviral therapy: contribution to the development of the human immunodeficiency virus associated lipodystrophy syndrome publication-title: Blood contributor: fullname: Gougeon
SSID	ssj0009396
Score	1.8359246
Snippet	Objectives. Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-α and IL-1β) can... Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-alpha and IL-1beta) can induce... Objectives. Abnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-[alpha] and... OBJECTIVESAbnormalities of insulin sensitivity are increasingly reported in HIV infection. Considering that cytokines (particularly TNF-alpha and IL-1beta) can...
SourceID	proquest crossref pubmed pascalfrancis elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	52
SubjectTerms	Adult Biological and medical sciences Blood Glucose - analysis cytokines HIV infection HIV Infections - blood HIV Infections - physiopathology Human viral diseases Humans Hydrocortisone - blood Infectious diseases Insulin - blood insulin resistance Insulin Resistance - physiology Interleukin-1 - blood Male Medical sciences Tumor Necrosis Factor-alpha - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
Title	Insulin resistance in HIV-infected patients: relationship with pro-inflammatory cytokines released by peripheral leukocytes
URI	https://dx.doi.org/10.1016/S0163-4453(03)00055-0 https://www.ncbi.nlm.nih.gov/pubmed/12850163 https://search.proquest.com/docview/18807240 https://search.proquest.com/docview/73460359
Volume	47
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9swFBZpC2NQxtbd0m2dHlbYGG4V6xbvrawZTWFj0K70zciyPLq2ScnloezP7xxLtpKNsAvsJSSKYpmcz0fHx9_5DiGvRKlLVmY8sT2lEtGzOsl01UusdFoam5Wyh8XJRyf603n_cCAGnU7TFTOO_VdLwxjYGitn_8La7UFhAN6DzeEVrA6vf2T3YSCXw200hoZ43aKc1fAs8bwrCDCDlmpNhps0ZDgkbdVJWXCpOBWQcu2fwNvb2fgS2fF1gxXY9eqYFRWSa0mCq7dXbn45hlmBjvgtAvB4UZfCs74iBQhQ4tOpnw144IVsPZx-KL5B1nf7zRm2ffH1RfNJO3rovl6MsfFSqDy6MEuJDN6SXkN2ramwiXSmOuGpeCKEFxTec42TxpIiseTFvW7nElq9S_YCuWFz9zLxv2wbPoNx0i62iz27dtO6oapMWNwrWwZjPRengpPESWyNbKTg68DVbhwMB-fHUfmZ103i2mPHMrL9uOBrxt-ExVYFSJs3ZgqXbeX7ray-IaoDo9P75F4wMT3wUHxAOm60Re58DJyNLbLpM8PUF7w9JN8DQmlEKIVPiwilDULf0UV8UsQn_RmftMUnbfBJi1sa8UkjPh-RLx8Gp--PktACJLEiTWeJcSo1KmVGssIVzEpmlehlRiqrDee6KGxZSmFSlaWlE8zA3Q8qfDqpK1uVkj8m6yMA81NCLZhH6kJxY0rYtUxhmDSyr7SqskJXRZfsNf97fuOVXvIFCqTiORoqZzyvDZWzLuk31slDuOrD0Bxg9buf7ixZMy4oUQJTqC552Zg3B3-PD_HMyI3n0xz1EzWE4atnaC4UCnN2yROPi3j0tC_xdLb__cyfkbvx2n1O1meTuXtB1qblfCcA_wdCrOKD
link.rule.ids	315,782,786,27933,27934
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Insulin+resistance+in+HIV-infected+patients%3A+relationship+with+pro-inflammatory+cytokines+released+by+peripheral+leukocytes&rft.jtitle=The+Journal+of+infection&rft.au=Limone%2C+Paolo&rft.au=Biglino%2C+Alberto&rft.au=Valle%2C+Mauro&rft.au=Degioanni%2C+Maria&rft.date=2003-07-01&rft.pub=Elsevier+Ltd&rft.issn=0163-4453&rft.eissn=1532-2742&rft.volume=47&rft.issue=1&rft.spage=52&rft.epage=58&rft_id=info:doi/10.1016%2FS0163-4453%2803%2900055-0&rft.externalDocID=S0163445303000550
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0163-4453&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0163-4453&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0163-4453&client=summon