Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study

• Published in: Scientific reports Vol. 14; no. 1; pp. 25395 - 6
• Main Authors: Nio, Kouki, Shimakami, Tetsuro, Terashima, Takeshi, Yanagi, Masahiro, Toyama, Tadashi, Koshikawa, Naohiko, Nakagawa, Masatoshi, Yoshida, Eisaku, Yoshimura, Toru, Seiki, Motoharu, Honda, Masao, Yamashita, Taro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25-10-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67; 631/67/1857; 631/67/2322; Adult; Aged; Biomarkers; Biomarkers, Tumor - blood; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - virology; Chronic infection; Cryopreservation; Female; Hepatitis; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic - blood; Hepatitis B, Chronic - complications; Hepatitis C; Hepatocellular carcinoma; Humanities and Social Sciences; Humans; Laminin; Laminin - blood; Liver cancer; Liver diseases; Liver Neoplasms - blood; Liver Neoplasms - diagnosis; Liver Neoplasms - etiology; Liver Neoplasms - virology; Male; Middle Aged; Monomers; multidisciplinary; Prognosis; Regression analysis; Retrospective Studies; Risk Factors; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-77068-4

This retrospective study evaluated the use of laminin γ2 monomer (LG2m) as a predictive biomarker for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Serum LG2m levels were measured in two cohorts of patients: cohort 1 comprised 56 patients with chronic liver disease for assessing LG2m stability, whereas cohort 2 included 89 patients with chronic HBV infection who did not have HCC for evaluating the usefulness of LG2m measurement in HCC prediction. LG2m was highly stable in cryopreserved serum, and an increased LG2m level was significantly associated with a higher risk of HCC in chronically HBV-infected patients (P = 0.012). Multivariable Cox regression analysis revealed that high LG2m was an independent significant risk factor for HCC (hazard ratio, 7.16; 95% confidence interval, 1.31–39.2; P = 0.023). These findings suggest that LG2m may serve as a useful biomarker for the prediction of future HCC in patients with chronic HBV infection.