Fabrication and evaluation of a medicated hydrogel film with embelin from Embelia ribes for wound healing activity

Background There has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment of wound healing. This research work involves development and evaluation of medicated hydrogel sheet incorporated with embelin which has both antimic...

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Published in:	Future journal of pharmaceutical sciences Vol. 5; no. 1; pp. 1 - 10
Main Authors:	Shrimali, Hiral, Mandal, Uttam Kumar, Nivsarkar, Manish, Shrivastava, Neeta
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 17-12-2019 Springer Nature B.V SpringerOpen
Subjects:	Chromatography Embelin Fruits Hydrogel sheet Hydrogels Laboratories Medicine Medicine & Public Health Pharmaceutical sciences Polyethylene glycol Polyvinyl alcohol Spectrum analysis Wound healing Mumbai India United States > US China India Polyvinyl alcohol Wound healing Embelin Polyethylene glycol Hydrogel sheet
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Abstract	Background There has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment of wound healing. This research work involves development and evaluation of medicated hydrogel sheet incorporated with embelin which has both antimicrobial and wound healing activity. Embelin was isolated from the fruits of Embelia ribes and characterized by various physical and analytical methods like melting point, UV/VIS spectroscopy, and HPTLC. The hydrogel sheets containing polyvinyl alcohol and polyethylene glycol was prepared by freeze-thaw technique, where isolated embelin was successfully incorporated within the sheet. The prepared hydrogel sheets were further characterized by in vitro drug release study, swelling capacities, gel fraction, water vapor transmission rate (WVTR), mechanical strength, and scanning electron microscopy (SEM) study. Finally, the optimized hydrogel with embelin was evaluated for its wound healing efficacy in vivo using excision wound model on Sprague–Dawley rats. Results The optimized hydrogel sheet had a composition of 5% PEG 400 and 10% PVA. It had acceptable in physico-chemical properties with respect to swelling capacities, gel fraction, water vapor transmission rate (WVTR), and mechanical strength The release of the drug from hydrogel followed zero order kinetics with more than 80% drug release within 12 h. The in vivo studies on the Sprague–Dawley showed faster healing process with embelin loaded hydrogels as compared to the control and market formulation. Conclusions Sheet hydrogel with 0.2% embelin was found to have huge potential for moist wound healing activity.
AbstractList	BackgroundThere has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment of wound healing. This research work involves development and evaluation of medicated hydrogel sheet incorporated with embelin which has both antimicrobial and wound healing activity. Embelin was isolated from the fruits of Embelia ribes and characterized by various physical and analytical methods like melting point, UV/VIS spectroscopy, and HPTLC. The hydrogel sheets containing polyvinyl alcohol and polyethylene glycol was prepared by freeze-thaw technique, where isolated embelin was successfully incorporated within the sheet. The prepared hydrogel sheets were further characterized by in vitro drug release study, swelling capacities, gel fraction, water vapor transmission rate (WVTR), mechanical strength, and scanning electron microscopy (SEM) study. Finally, the optimized hydrogel with embelin was evaluated for its wound healing efficacy in vivo using excision wound model on Sprague–Dawley rats.ResultsThe optimized hydrogel sheet had a composition of 5% PEG 400 and 10% PVA. It had acceptable in physico-chemical properties with respect to swelling capacities, gel fraction, water vapor transmission rate (WVTR), and mechanical strength The release of the drug from hydrogel followed zero order kinetics with more than 80% drug release within 12 h. The in vivo studies on the Sprague–Dawley showed faster healing process with embelin loaded hydrogels as compared to the control and market formulation.ConclusionsSheet hydrogel with 0.2% embelin was found to have huge potential for moist wound healing activity. Abstract Background There has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment of wound healing. This research work involves development and evaluation of medicated hydrogel sheet incorporated with embelin which has both antimicrobial and wound healing activity. Embelin was isolated from the fruits of Embelia ribes and characterized by various physical and analytical methods like melting point, UV/VIS spectroscopy, and HPTLC. The hydrogel sheets containing polyvinyl alcohol and polyethylene glycol was prepared by freeze-thaw technique, where isolated embelin was successfully incorporated within the sheet. The prepared hydrogel sheets were further characterized by in vitro drug release study, swelling capacities, gel fraction, water vapor transmission rate (WVTR), mechanical strength, and scanning electron microscopy (SEM) study. Finally, the optimized hydrogel with embelin was evaluated for its wound healing efficacy in vivo using excision wound model on Sprague–Dawley rats. Results The optimized hydrogel sheet had a composition of 5% PEG 400 and 10% PVA. It had acceptable in physico-chemical properties with respect to swelling capacities, gel fraction, water vapor transmission rate (WVTR), and mechanical strength The release of the drug from hydrogel followed zero order kinetics with more than 80% drug release within 12 h. The in vivo studies on the Sprague–Dawley showed faster healing process with embelin loaded hydrogels as compared to the control and market formulation. Conclusions Sheet hydrogel with 0.2% embelin was found to have huge potential for moist wound healing activity. Background There has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment of wound healing. This research work involves development and evaluation of medicated hydrogel sheet incorporated with embelin which has both antimicrobial and wound healing activity. Embelin was isolated from the fruits of Embelia ribes and characterized by various physical and analytical methods like melting point, UV/VIS spectroscopy, and HPTLC. The hydrogel sheets containing polyvinyl alcohol and polyethylene glycol was prepared by freeze-thaw technique, where isolated embelin was successfully incorporated within the sheet. The prepared hydrogel sheets were further characterized by in vitro drug release study, swelling capacities, gel fraction, water vapor transmission rate (WVTR), mechanical strength, and scanning electron microscopy (SEM) study. Finally, the optimized hydrogel with embelin was evaluated for its wound healing efficacy in vivo using excision wound model on Sprague–Dawley rats. Results The optimized hydrogel sheet had a composition of 5% PEG 400 and 10% PVA. It had acceptable in physico-chemical properties with respect to swelling capacities, gel fraction, water vapor transmission rate (WVTR), and mechanical strength The release of the drug from hydrogel followed zero order kinetics with more than 80% drug release within 12 h. The in vivo studies on the Sprague–Dawley showed faster healing process with embelin loaded hydrogels as compared to the control and market formulation. Conclusions Sheet hydrogel with 0.2% embelin was found to have huge potential for moist wound healing activity.
ArticleNumber	12
Author	Nivsarkar, Manish Shrivastava, Neeta Shrimali, Hiral Mandal, Uttam Kumar
Author_xml	– sequence: 1 givenname: Hiral surname: Shrimali fullname: Shrimali, Hiral organization: National Institute of Pharmaceutical Education and Research (NIPER) – sequence: 2 givenname: Uttam Kumar surname: Mandal fullname: Mandal, Uttam Kumar organization: Department of Pharmaceutical Sciences & Technology, Maharaja Ranjit Singh Punjab Technical University – sequence: 3 givenname: Manish surname: Nivsarkar fullname: Nivsarkar, Manish organization: B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre – sequence: 4 givenname: Neeta surname: Shrivastava fullname: Shrivastava, Neeta email: neetashrivastavaperd@gmail.com organization: B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre
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CitedBy_id	crossref_primary_10_1007_s13233_022_0062_4 crossref_primary_10_1016_j_ijbiomac_2022_05_063 crossref_primary_10_1016_j_mtcomm_2022_104203 crossref_primary_10_2174_1573412918666220118113546 crossref_primary_10_1080_14786419_2021_1955361 crossref_primary_10_2174_2213337208666211102104240 crossref_primary_10_2174_2210681213666230526152322 crossref_primary_10_1021_acsomega_3c09522 crossref_primary_10_1186_s43094_021_00210_w crossref_primary_10_3390_ph17030303 crossref_primary_10_3390_gels9060476
Cites_doi	10.1038/193293a0 10.1016/j.jep.2006.09.003 10.1016/j.burns.2011.09.020 10.1016/j.ijpharm.2010.03.024 10.1023/A:1008983215833 10.1016/j.jaad.2007.08.048 10.1016/j.mpsur.2017.06.005 10.1016/S0367-326X(03)00066-2 10.1016/j.burns.2008.03.009 10.1016/j.phymed.2010.04.002 10.1080/10837450.2017.1295067 10.1016/j.ijpharm.2008.03.021 10.1088/1748-6041/5/6/065014 10.12968/jowc.2004.13.6.26625 10.1016/j.nimb.2004.12.135 10.1016/j.cbi.2007.02.004 10.1016/j.ijpharm.2007.06.021 10.1016/j.carbpol.2010.09.048
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Copyright	The Author(s) 2019 The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: The Author(s) 2019 – notice: The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords	Polyvinyl alcohol Wound healing Embelin Polyethylene glycol Hydrogel sheet
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Snippet	Background There has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment of wound... BackgroundThere has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment of wound... Abstract Background There has been huge interest among the researchers to incorporate a medicinally active compounds in hydrogel sheets for effective treatment...
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SubjectTerms	Chromatography Embelin Fruits Hydrogel sheet Hydrogels Laboratories Medicine Medicine & Public Health Pharmaceutical sciences Polyethylene glycol Polyvinyl alcohol Spectrum analysis Wound healing
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Title	Fabrication and evaluation of a medicated hydrogel film with embelin from Embelia ribes for wound healing activity
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