Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses

A systematic, comprehensive strategy that optimizes sample preparation and chromatography to minimize matrix effects in bioanalytical LC/MS/MS assays was developed. Comparisons were made among several sample preparation methods, including protein precipitation (PPT), liquid–liquid extraction (LLE),...

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Bibliographic Details
Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 852; no. 1; pp. 22 - 34
Main Authors:	Chambers, Erin, Wagrowski-Diehl, Diane M., Lu, Ziling, Mazzeo, Jeffrey R.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-06-2007 Elsevier Science
Subjects:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, High Pressure Liquid - methods Chromatography, Ion Exchange - methods Fundamental and applied biological sciences. Psychology General pharmacology HPLC Hydrogen-Ion Concentration Mass spectrometry Matrix effects Medical sciences Pharmacology. Drug treatments Phospholipids Phospholipids - analysis Quantitative bioanalysis Sample preparation Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods UPLC Sample preparation UPLC Quantitative bioanalysis Matrix effects Phospholipids Mass spectrometry HPLC Ultra performance liquid chromatography HPLC chromatography Phospholipid Liquid chromatography Matrix effect Complex lipid Quantitative analysis
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