Perspectives on carbon nanotube-mediated adverse immune effects

Carbon nanotubes are entities of different morphology and aspect ratios with anisotropic character. Due to their unique electronic, photonic, mechanical and chemical properties, carbon nanotubes are receiving increasing attention in nanomedicine research where examples include site-specific drug and...

Full description

Saved in:

Bibliographic Details
Published in:	Advanced drug delivery reviews Vol. 64; no. 15; pp. 1700 - 1705
Main Authors:	Andersen, Alina J., Wibroe, Peter P., Moghimi, S. Moein
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-12-2012
Subjects:	Animals Anisotropy Complement Activation - drug effects Complement Activation - immunology Complement system Complement System Proteins - drug effects Complement System Proteins - immunology Cytokines Humans Immune cells Immune System - cytology Immune System - drug effects Injections, Intravenous Macrophage Macrophages - metabolism Multi-walled carbon nanotubes Nanotubes, Carbon - toxicity Pharmacokinetics Single-walled carbon nanotubes Cytokines Complement system Immune cells Pharmacokinetics Multi-walled carbon nanotubes Single-walled carbon nanotubes Macrophage
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Carbon nanotubes are entities of different morphology and aspect ratios with anisotropic character. Due to their unique electronic, photonic, mechanical and chemical properties, carbon nanotubes are receiving increasing attention in nanomedicine research where examples include site-specific drug and nucleic acid delivery, photodynamic therapy and photoacoustic molecular imaging. The interaction of carbon nanotubes with the immune system, which plays a key role in the recognition and elimination of foreign materials, and consequential responses, is of central importance for the proposed successful biomedical applications of nanotubes. Research in this avenue, however, is scant and the limited available data are rather contradictory. In this progress article we have collected some of the most important experimental results obtained thus far on carbon nanotube-mediated immune toxicity with an emphasis on cardiovascular exposure, including activation of the complement system, macrophage recognition and clearance, and overall effects on the functionality of different immune cells. Mapping these immune-related risks as well as understanding their molecular mechanisms is a crucial step in the development of any carbon nanotube-containing nanopharmaceuticals. [Display omitted]
AbstractList	Carbon nanotubes are entities of different morphology and aspect ratios with anisotropic character. Due to their unique electronic, photonic, mechanical and chemical properties, carbon nanotubes are receiving increasing attention in nanomedicine research where examples include site-specific drug and nucleic acid delivery, photodynamic therapy and photoacoustic molecular imaging. The interaction of carbon nanotubes with the immune system, which plays a key role in the recognition and elimination of foreign materials, and consequential responses, is of central importance for the proposed successful biomedical applications of nanotubes. Research in this avenue, however, is scant and the limited available data are rather contradictory. In this progress article we have collected some of the most important experimental results obtained thus far on carbon nanotube-mediated immune toxicity with an emphasis on cardiovascular exposure, including activation of the complement system, macrophage recognition and clearance, and overall effects on the functionality of different immune cells. Mapping these immune-related risks as well as understanding their molecular mechanisms is a crucial step in the development of any carbon nanotube-containing nanopharmaceuticals. Carbon nanotubes are entities of different morphology and aspect ratios with anisotropic character. Due to their unique electronic, photonic, mechanical and chemical properties, carbon nanotubes are receiving increasing attention in nanomedicine research where examples include site-specific drug and nucleic acid delivery, photodynamic therapy and photoacoustic molecular imaging. The interaction of carbon nanotubes with the immune system, which plays a key role in the recognition and elimination of foreign materials, and consequential responses, is of central importance for the proposed successful biomedical applications of nanotubes. Research in this avenue, however, is scant and the limited available data are rather contradictory. In this progress article we have collected some of the most important experimental results obtained thus far on carbon nanotube-mediated immune toxicity with an emphasis on cardiovascular exposure, including activation of the complement system, macrophage recognition and clearance, and overall effects on the functionality of different immune cells. Mapping these immune-related risks as well as understanding their molecular mechanisms is a crucial step in the development of any carbon nanotube-containing nanopharmaceuticals. [Display omitted]
Author	Moghimi, S. Moein Wibroe, Peter P. Andersen, Alina J.
Author_xml	– sequence: 1 givenname: Alina J. surname: Andersen fullname: Andersen, Alina J. – sequence: 2 givenname: Peter P. surname: Wibroe fullname: Wibroe, Peter P. – sequence: 3 givenname: S. Moein surname: Moghimi fullname: Moghimi, S. Moein email: momo@farma.ku.dk
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22634159$$D View this record in MEDLINE/PubMed
BookMark	eNp9kM1KxDAYRYOMOD_6Ai6kSzetX9KkTUEQGfyDAV0ouAtp8gU6TNsxaQd8ezPM6NLV3Zx74Z45mXR9h4RcUsgo0OJmnWlrfcaAsgxEBiBOyIzKkqWSVXxCZhGqUg7V55TMQ1hDBMsCzsiUsSLnVFQzcveGPmzRDM0OQ9J3idG-jtHprh_GGtMWbaMHtIm2u4hi0rTt2GGCzsVWOCenTm8CXhxzQT4eH96Xz-nq9elleb9KDWdsSHNBpeDgZCmcNRXKXHKmS5RQ1QxsYYV2CIZxJnLtcldokEJzMLSsHa1NviDXh92t779GDINqm2Bws9Ed9mNQ8RkrqcxLFlF2QI3vQ_Do1NY3rfbfioLai1NrtRen9uIUCBXFxdLVcX-s4-W_yq-pCNweAIwvdw16FUyDnYl6fBShbN_8t_8D_0-Aaw
CitedBy_id	crossref_primary_10_1002_wnan_1263 crossref_primary_10_1016_j_addr_2012_09_002 crossref_primary_10_1016_j_nano_2016_02_012 crossref_primary_10_1016_j_nano_2014_02_010 crossref_primary_10_1002_jbio_201800035 crossref_primary_10_1016_j_ijpharm_2017_04_048 crossref_primary_10_1016_j_biopha_2023_115597 crossref_primary_10_1016_j_biomaterials_2014_03_041 crossref_primary_10_1016_j_nano_2014_01_004 crossref_primary_10_1021_acs_nanolett_7b00189 crossref_primary_10_1016_j_colsurfb_2017_05_008 crossref_primary_10_1021_nl403396e crossref_primary_10_1016_j_lfs_2020_118059 crossref_primary_10_1016_j_mattod_2014_07_009 crossref_primary_10_1080_1547691X_2016_1191562 crossref_primary_10_1016_j_nano_2015_06_009 crossref_primary_10_3390_c6010012 crossref_primary_10_1016_j_jconrel_2013_05_042 crossref_primary_10_1021_acsnano_6b05409 crossref_primary_10_1039_c3pc90010j crossref_primary_10_1088_0957_4484_24_1_015106 crossref_primary_10_1016_j_addr_2013_07_006 crossref_primary_10_3390_biomimetics5040053 crossref_primary_10_1155_2016_9417874 crossref_primary_10_1016_j_jddst_2022_103098 crossref_primary_10_1039_C5TB01825K crossref_primary_10_1016_j_biomaterials_2015_11_028 crossref_primary_10_1021_acs_bioconjchem_1c00339 crossref_primary_10_1021_acs_bioconjchem_5b00031 crossref_primary_10_1016_j_addr_2013_05_012 crossref_primary_10_29328_journal_hjb_1001007 crossref_primary_10_1002_adma_201402996 crossref_primary_10_1155_2018_8796583 crossref_primary_10_1016_j_biopha_2016_08_060 crossref_primary_10_1039_C5TX00373C crossref_primary_10_1021_acs_nanolett_1c02746 crossref_primary_10_1155_2015_564087 crossref_primary_10_1016_j_cbi_2023_110355 crossref_primary_10_1186_s12989_019_0299_z crossref_primary_10_3390_fib2010045
Cites_doi	10.1016/j.jconrel.2010.04.003 10.1021/nn101990a 10.1038/nnano.2006.209 10.1166/jnn.2004.146 10.1073/pnas.0913667107 10.1038/nmat877 10.1016/j.cbpa.2005.10.005 10.1038/nnano.2006.170 10.1016/j.addr.2011.05.012 10.1038/nnano.2007.70 10.1021/nl061160x 10.2217/nnm.11.101 10.1038/sj.bjp.0706386 10.1016/j.addr.2011.06.002 10.1016/j.molimm.2008.08.276 10.1146/annurev-pharmtox-010611-134623 10.1016/j.molimm.2008.05.020 10.1073/pnas.0707654105 10.1016/j.tox.2009.10.034 10.1080/08982100701375118 10.1080/08958370902942574 10.1038/nnano.2009.151 10.2131/jts.37.177 10.1016/j.nano.2008.04.002 10.1063/1.1813631 10.1002/smll.200800323 10.1021/nn2038252 10.1166/jbn.2011.1347 10.1371/journal.pone.0021073 10.1016/S1748-0132(07)70172-X 10.1126/science.280.5367.1253 10.1016/j.aquatox.2010.07.023 10.1093/toxsci/kfp057 10.1038/ni.1923 10.1158/0008-5472.CAN-08-1468 10.2217/nnm.11.169 10.1021/bm201020h 10.1021/cr970102g 10.1172/JCI25982 10.1002/anie.200503389 10.1021/ja037746s 10.1021/ja016954m 10.1021/nn200283g 10.1073/pnas.1100930108 10.1016/j.molimm.2005.02.006 10.1038/nnano.2010.109 10.1002/aja.1001810302 10.4049/jimmunol.0903678 10.1166/jnn.2008.090 10.1189/jlb.0604341 10.1021/ja047451u 10.1021/nn102400w 10.1039/a909240d 10.1021/nl015680y 10.1098/rsta.2004.1430 10.1021/jp070712c 10.1016/j.bbcan.2010.02.004 10.1021/nl048969z 10.1038/nnano.2008.231 10.1016/j.toxlet.2008.07.020 10.1038/354056a0 10.1073/pnas.0509009103 10.1016/j.jconrel.2011.10.036 10.1038/nnano.2008.68 10.1097/01.shk.0000142249.08135.e9
ContentType	Journal Article
Copyright	2012 Elsevier B.V. Copyright © 2012 Elsevier B.V. All rights reserved.
Copyright_xml	– notice: 2012 Elsevier B.V. – notice: Copyright © 2012 Elsevier B.V. All rights reserved.
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 7T5 8FD FR3 H94 P64
DOI	10.1016/j.addr.2012.05.005
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Biotechnology Research Abstracts Immunology Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts
DatabaseTitleList	MEDLINE AIDS and Cancer Research Abstracts
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology Pharmacy, Therapeutics, & Pharmacology
EISSN	1872-8294
EndPage	1705
ExternalDocumentID	10_1016_j_addr_2012_05_005 22634159 S0169409X12001846
Genre	Research Support, Non-U.S. Gov't Journal Article Review
GroupedDBID	--- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23M 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFNM ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HX~ HZ~ IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSP SSU SSZ T5K TEORI WUQ Y6R ~G- AAXKI ADVLN AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 7T5 8FD FR3 H94 P64
ID	FETCH-LOGICAL-c422t-3518540f875fdc9e83842a7e809b20d6d5afe0c24253af3f6a085a40c17bf1bc3
ISSN	0169-409X
IngestDate	Fri Oct 25 01:30:42 EDT 2024 Thu Sep 26 17:51:44 EDT 2024 Sat Sep 28 07:52:11 EDT 2024 Fri Feb 23 02:29:07 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	15
Keywords	Cytokines Complement system Immune cells Pharmacokinetics Multi-walled carbon nanotubes Single-walled carbon nanotubes Macrophage
Language	English
License	Copyright © 2012 Elsevier B.V. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c422t-3518540f875fdc9e83842a7e809b20d6d5afe0c24253af3f6a085a40c17bf1bc3
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
PMID	22634159
PQID	1272718372
PQPubID	23462
PageCount	6
ParticipantIDs	proquest_miscellaneous_1272718372 crossref_primary_10_1016_j_addr_2012_05_005 pubmed_primary_22634159 elsevier_sciencedirect_doi_10_1016_j_addr_2012_05_005
PublicationCentury	2000
PublicationDate	2012-12-01
PublicationDateYYYYMMDD	2012-12-01
PublicationDate_xml	– month: 12 year: 2012 text: 2012-12-01 day: 01
PublicationDecade	2010
PublicationPlace	Netherlands
PublicationPlace_xml	– name: Netherlands
PublicationTitle	Advanced drug delivery reviews
PublicationTitleAlternate	Adv Drug Deliv Rev
PublicationYear	2012
Publisher	Elsevier B.V
Publisher_xml	– name: Elsevier B.V
References	Moghimi, Hunter, Andresen (bb0200) 2012; 52 Watanabe, Numata, Ito, Takagi, Matsukawa (bb0295) 2004; 22 Ricklin, Hajishengallis, Yang, Lambris (bb0140) 2010; 11 Liu, Rinzler, Dai, Hafner, Bradley, Boul, Lu, Iverson, Shelimov, Huffman, Rodriguez-Macias, Shon, Lee, Colbert, Smalley (bb0030) 1998; 280 Chen, Oppenheim, Howard (bb0300) 2005; 78 Hamad, Hunter, Szebeni, Moghimi (bb0190) 2008; 46 Kostarelos, Lacerda, Pastorin, Wu, Wieckowski, Luangsivilay, Godefroy, Pantarotto, Briand, Muller, Prato, Bianco (bb0090) 2007; 2 Zheng, Jagota, Semke, Diner, McLean, Lustig, Richardson, Tassi (bb0060) 2003; 2 Iijima (bb0005) 1991; 354 Pompeo, Resasco (bb0035) 2002; 2 Yurekli, Mitchell, Krishnamoorti (bb0055) 2004; 126 Moghimi, Andersen, Hashemi, Lettiero, Ahmadvand, Hunter, Andresen, Hamad, Szebeni (bb0135) 2010; 146 Winkler (bb0325) 1988; 181 Sun, Liu, Meng, Meng, Duan, Xie, Lu, Zhu, Wang, Chen, Xu, Yang (bb0240) 2011; 6 Bottini, Rosato, Bottini (bb0045) 2011; 12 Liu, Chen, Davis, Sherlock, Cao, Chen, Dai (bb0105) 2008; 68 Ling, Biro, Bally, Tacnet, Deniaud, Doris, Frachet, Schoehn, Pebay-Peyroula, Arlaud (bb0170) 2011; 5 Schipper, Nakayama-Ratchford, Davis, Kam, Chu, Liu, Sun, Dai, Gambhir (bb0265) 2008; 3 Peng, Alemany, Margrave, Khabashesku (bb0020) 2003; 125 Klaper, Arndt, Setyowati, Chen, Goetz (bb0245) 2010; 100 Salvador-Morales, Flahaut, Sim, Sloan, Green, Sim (bb0165) 2006; 43 Salvador-Morales, Basiuk, Basiuk, Green, Sim (bb0175) 2008; 8 Szebeni, Alving, Rosivall, Bünger, Baranyi, Bedöcs, Tóth, Barenholz (bb0320) 2007; 17 Wang, Zhou, Ho, Winey, Fischer, Glinka, Hobbie (bb0050) 2004; 4 Rao, Lee, Lu, Keskar, Freedman, Floyd, Rao, Ke (bb0065) 2004; 85 Kam, Liu, Dai (bb0085) 2006; 45 Gao, Zhang, Mu, Bai, Li, Zhou, Butch, Powell, Snyder, Jiang, Yan (bb0275) 2011; 5 Ruggiero, Villa, Bander, Rey, Bergkvist, Batt, Manova-Todorova, Deen, Scheinberg, McDevitt (bb0220) 2010; 107 Mitchell, Lauer, Burchiel, McDonald (bb0310) 2009; 4 Bianco, Kostarelos, Prato (bb0075) 2005; 9 De la Zerda, Zavaleta, Keren, Vaithilingam, Bodapati, Liu, Levi, Smith, Ma, Oralkan, Cheng, Chen, Dai, Khuri-Yakub, Gambhir (bb0115) 2008; 3 Yang, Wang, Jia, Gu, Wang, Nie, Ge, Wang, Liu (bb0285) 2008; 181 Rybak-Smith, Sim (bb0160) 2011; 63 Hamad, Hunter, Rutt, Liu, Dai, Moghimi (bb0180) 2008; 45 Amara, Flierl, Rittirsch, Klos, Chen, Acker, Brückner, Nilsson, Gebhard, Lambris, Huber-Lang (bb0155) 2010; 185 Dresselhaus, Dresselhaus, Charlier, Hernández (bb0010) 2004; 362 Yamaguchi, Fujitani, Ohyama, Nakae, Hirose, Nishimura, Ogata (bb0315) 2012; 37 Foldvari, Bagonluri (bb0015) 2008; 4 Boraschi, Costantino, Italiani (bb0120) 2012; 7 Palomäki, Karisola, Pylkkänen, Savolainen, Alenius (bb0255) 2010; 267 Shi, Lian, Zhou, Gu, Zhang, Iijima, Gong, Li, Zhang (bb0025) 2000 Ji, Liu, Zang, Yang, Xu, Long, Jin, Fu, Ni, Yu (bb0110) 2010; 1806 Selander, Mårtensson, Weintraub, Holmström, Matsushita, Thiel, Jensenius, Truedsson, Sjöholm (bb0150) 2006; 116 Lettiero, Andersen, Hunter, Moghimi (bb0145) 2012; 161 Rybak-Smith, Tripisciano, Borowiak-Palen, Lamprecht, Sim (bb0195) 2011; 7 Liu, Cai, He, Nakayama, Chen, Sun, Chen, Dai (bb0070) 2007; 2 Radomski, Jurasz, Alonso-Escolano, Drews, Morandi, Malinski, Radomski (bb0305) 2005; 146 Moghimi, Peer, Langer (bb0130) 2011; 5 Nygaard, Hansen, Samuelsen, Alberg, Marioara, Løvik (bb0290) 2009; 109 Hamad, Al-Hanbali, Hunter, Rutt, Andresen, Moghimi (bb0185) 2010; 4 Delogu, Venturelli, Manetti, Pinna, Carru, Madeddu, Murgia, Sgarrella, Dumortier, Bianco (bb0235) 2012; 7 Witasp, Shvedova, Kagan, Fadeel (bb0250) 2009; 21 Ajayan (bb0095) 1999; 99 Wang, Wang, Deng, Sun, Shi, Gu, Liu, Zhao (bb0210) 2004; 4 Lacerda, Herrero, Venner, Bianco, Prato, Kostarelos (bb0225) 2008; 4 Moghimi, Hunter (bb0230) 2010; 5 Geng, Dalhaimer, Cai, Tsai, Tewari, Minko, Discher (bb0205) 2007; 2 Dumortier, Lacotte, Pastorin, Marega, Wu, Bonifazi, Briand, Prato, Muller, Bianco (bb0260) 2006; 6 Lacerda, Raffa, Prato, Bianco, Kostarelos (bb0080) 2007; 2 Yang, Guo, Lin, Deng, Wang, Sun, Liu, Wang, Wang, Chen, Huang, Sun (bb0280) 2007; 111 Singh, Pantarotto, Lacerda, Pastorin, Klumpp, Prato, Bianco, Kostarelos (bb0215) 2006; 103 Georgakilas, Kordatos, Prato, Guldi, Holzinger, Hirsch (bb0040) 2002; 124 Liu, Davis, Cai, He, Chen, Dai (bb0270) 2008; 105 Al-Jamal, Gherardini, Bardi, Nunes, Guo, Bussy, Herrero, Bianco, Prato, Kostarelos, Pizzorusso (bb0100) 2011; 108 Moghimi, Andersen, Ahmadvand, Wibroe, Andresen, Hunter (bb0125) 2011; 63 Liu (10.1016/j.addr.2012.05.005_bb0070) 2007; 2 Lettiero (10.1016/j.addr.2012.05.005_bb0145) 2012; 161 Lacerda (10.1016/j.addr.2012.05.005_bb0225) 2008; 4 Ling (10.1016/j.addr.2012.05.005_bb0170) 2011; 5 Moghimi (10.1016/j.addr.2012.05.005_bb0130) 2011; 5 Rybak-Smith (10.1016/j.addr.2012.05.005_bb0195) 2011; 7 Winkler (10.1016/j.addr.2012.05.005_bb0325) 1988; 181 Rybak-Smith (10.1016/j.addr.2012.05.005_bb0160) 2011; 63 Delogu (10.1016/j.addr.2012.05.005_bb0235) 2012; 7 Kam (10.1016/j.addr.2012.05.005_bb0085) 2006; 45 Liu (10.1016/j.addr.2012.05.005_bb0030) 1998; 280 Chen (10.1016/j.addr.2012.05.005_bb0300) 2005; 78 Szebeni (10.1016/j.addr.2012.05.005_bb0320) 2007; 17 Moghimi (10.1016/j.addr.2012.05.005_bb0200) 2012; 52 Hamad (10.1016/j.addr.2012.05.005_bb0180) 2008; 45 Amara (10.1016/j.addr.2012.05.005_bb0155) 2010; 185 Rao (10.1016/j.addr.2012.05.005_bb0065) 2004; 85 Wang (10.1016/j.addr.2012.05.005_bb0050) 2004; 4 Singh (10.1016/j.addr.2012.05.005_bb0215) 2006; 103 Salvador-Morales (10.1016/j.addr.2012.05.005_bb0175) 2008; 8 Georgakilas (10.1016/j.addr.2012.05.005_bb0040) 2002; 124 Boraschi (10.1016/j.addr.2012.05.005_bb0120) 2012; 7 De la Zerda (10.1016/j.addr.2012.05.005_bb0115) 2008; 3 Hamad (10.1016/j.addr.2012.05.005_bb0185) 2010; 4 Moghimi (10.1016/j.addr.2012.05.005_bb0135) 2010; 146 Moghimi (10.1016/j.addr.2012.05.005_bb0230) 2010; 5 Al-Jamal (10.1016/j.addr.2012.05.005_bb0100) 2011; 108 Selander (10.1016/j.addr.2012.05.005_bb0150) 2006; 116 Geng (10.1016/j.addr.2012.05.005_bb0205) 2007; 2 Palomäki (10.1016/j.addr.2012.05.005_bb0255) 2010; 267 Watanabe (10.1016/j.addr.2012.05.005_bb0295) 2004; 22 Dumortier (10.1016/j.addr.2012.05.005_bb0260) 2006; 6 Mitchell (10.1016/j.addr.2012.05.005_bb0310) 2009; 4 Foldvari (10.1016/j.addr.2012.05.005_bb0015) 2008; 4 Hamad (10.1016/j.addr.2012.05.005_bb0190) 2008; 46 Kostarelos (10.1016/j.addr.2012.05.005_bb0090) 2007; 2 Ji (10.1016/j.addr.2012.05.005_bb0110) 2010; 1806 Lacerda (10.1016/j.addr.2012.05.005_bb0080) 2007; 2 Schipper (10.1016/j.addr.2012.05.005_bb0265) 2008; 3 Liu (10.1016/j.addr.2012.05.005_bb0105) 2008; 68 Wang (10.1016/j.addr.2012.05.005_bb0210) 2004; 4 Yamaguchi (10.1016/j.addr.2012.05.005_bb0315) 2012; 37 Shi (10.1016/j.addr.2012.05.005_bb0025) 2000 Yang (10.1016/j.addr.2012.05.005_bb0285) 2008; 181 Liu (10.1016/j.addr.2012.05.005_bb0270) 2008; 105 Yang (10.1016/j.addr.2012.05.005_bb0280) 2007; 111 Peng (10.1016/j.addr.2012.05.005_bb0020) 2003; 125 Bianco (10.1016/j.addr.2012.05.005_bb0075) 2005; 9 Moghimi (10.1016/j.addr.2012.05.005_bb0125) 2011; 63 Nygaard (10.1016/j.addr.2012.05.005_bb0290) 2009; 109 Dresselhaus (10.1016/j.addr.2012.05.005_bb0010) 2004; 362 Gao (10.1016/j.addr.2012.05.005_bb0275) 2011; 5 Yurekli (10.1016/j.addr.2012.05.005_bb0055) 2004; 126 Zheng (10.1016/j.addr.2012.05.005_bb0060) 2003; 2 Iijima (10.1016/j.addr.2012.05.005_bb0005) 1991; 354 Bottini (10.1016/j.addr.2012.05.005_bb0045) 2011; 12 Witasp (10.1016/j.addr.2012.05.005_bb0250) 2009; 21 Sun (10.1016/j.addr.2012.05.005_bb0240) 2011; 6 Pompeo (10.1016/j.addr.2012.05.005_bb0035) 2002; 2 Ricklin (10.1016/j.addr.2012.05.005_bb0140) 2010; 11 Salvador-Morales (10.1016/j.addr.2012.05.005_bb0165) 2006; 43 Klaper (10.1016/j.addr.2012.05.005_bb0245) 2010; 100 Ajayan (10.1016/j.addr.2012.05.005_bb0095) 1999; 99 Ruggiero (10.1016/j.addr.2012.05.005_bb0220) 2010; 107 Radomski (10.1016/j.addr.2012.05.005_bb0305) 2005; 146
References_xml	– volume: 2 start-page: 47 year: 2007 end-page: 52 ident: bb0070 article-title: In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice publication-title: Nat. Nanotechnol. contributor: fullname: Dai – volume: 280 start-page: 1253 year: 1998 end-page: 1256 ident: bb0030 article-title: Fullerene pipes publication-title: Science contributor: fullname: Smalley – volume: 2 start-page: 369 year: 2002 end-page: 373 ident: bb0035 article-title: Water solubilization of single-walled carbon nanotubes by functionalization with glucosamine publication-title: Nano Lett. contributor: fullname: Resasco – volume: 107 start-page: 12369 year: 2010 end-page: 12374 ident: bb0220 article-title: Paradoxical glomerular filtration of carbon nanotubes publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: McDevitt – volume: 43 start-page: 193 year: 2006 end-page: 201 ident: bb0165 article-title: Complement activation and protein adsorption by carbon nanotubes publication-title: Mol. Immunol. contributor: fullname: Sim – volume: 85 start-page: 4228 year: 2004 end-page: 4230 ident: bb0065 article-title: Single-molecule fluorescence microscopy and Raman spectroscopy studies of RNA bound carbon nanotubes publication-title: Appl. Phys. Lett. contributor: fullname: Ke – volume: 6 start-page: e21073 year: 2011 ident: bb0240 article-title: Carbon nanotubes enhance cytotoxicity mediated by human lymphocytes in vitro publication-title: PLoS One contributor: fullname: Yang – volume: 8 start-page: 2347 year: 2008 end-page: 2356 ident: bb0175 article-title: Effects of covalent functionalization on the biocompatibility characteristics of multi-walled carbon nanotubes publication-title: J. Nanosci. Nanotechnol. contributor: fullname: Sim – volume: 126 start-page: 9902 year: 2004 end-page: 9903 ident: bb0055 article-title: Small-angle neutron scattering from surfactant-assisted aqueous dispersions of carbon nanotubes publication-title: J. Am. Chem. Soc. contributor: fullname: Krishnamoorti – volume: 354 start-page: 56 year: 1991 end-page: 58 ident: bb0005 article-title: Helical microtubules of graphitic carbon publication-title: Nature contributor: fullname: Iijima – volume: 124 start-page: 760 year: 2002 end-page: 761 ident: bb0040 article-title: Organic functionalization of carbon nanotubes publication-title: J. Am. Chem. Soc. contributor: fullname: Hirsch – volume: 4 start-page: 173 year: 2008 end-page: 182 ident: bb0015 article-title: Carbon nanotubes as functional excipients for nanomedicines: I. pharmaceutical properties publication-title: Nanomed. Nanotechnol. Biol. Med. contributor: fullname: Bagonluri – volume: 3 start-page: 557 year: 2008 end-page: 562 ident: bb0115 article-title: Carbon nanotubes as photoacoustic molecular imaging agents in living mice publication-title: Nat. Nanotechnol. contributor: fullname: Gambhir – volume: 46 start-page: 225 year: 2008 end-page: 232 ident: bb0190 article-title: Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process publication-title: Mol. Immunol. contributor: fullname: Moghimi – volume: 99 start-page: 1787 year: 1999 end-page: 1799 ident: bb0095 article-title: Nanotubes from carbon publication-title: Chem. Rev. contributor: fullname: Ajayan – volume: 5 start-page: 730 year: 2011 end-page: 737 ident: bb0170 article-title: Proteins of the innate immune system crystallize on carbon nanotubes but are not activated publication-title: ACS Nano contributor: fullname: Arlaud – volume: 45 start-page: 3797 year: 2008 end-page: 3803 ident: bb0180 article-title: Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover publication-title: Mol. Immunol. contributor: fullname: Moghimi – volume: 9 start-page: 674 year: 2005 end-page: 679 ident: bb0075 article-title: Applications of carbon nanotubes in drug delivery publication-title: Curr. Opin. Chem. Biol. contributor: fullname: Prato – volume: 17 start-page: 107 year: 2007 end-page: 117 ident: bb0320 article-title: Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles publication-title: J. Liposome Res. contributor: fullname: Barenholz – volume: 267 start-page: 125 year: 2010 end-page: 131 ident: bb0255 article-title: Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells publication-title: Toxicology contributor: fullname: Alenius – volume: 105 start-page: 1410 year: 2008 end-page: 1415 ident: bb0270 article-title: Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Dai – volume: 161 start-page: 283 year: 2012 end-page: 289 ident: bb0145 article-title: Complement system and the brain: selected pathologies and avenues toward engineering of neurological nanomedicines publication-title: J. Control. Release contributor: fullname: Moghimi – volume: 63 start-page: 1031 year: 2011 end-page: 1041 ident: bb0160 article-title: Complement activation by carbon nanotubes publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Sim – volume: 3 start-page: 216 year: 2008 end-page: 221 ident: bb0265 article-title: A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice publication-title: Nat. Nanotechnol. contributor: fullname: Gambhir – volume: 12 start-page: 3381 year: 2011 end-page: 3393 ident: bb0045 article-title: PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead publication-title: Biomacromolecules contributor: fullname: Bottini – volume: 7 start-page: 830 year: 2011 end-page: 839 ident: bb0195 article-title: Effect of functionalization of carbon nanotubes with psychosine on complement activation and protein adsorption publication-title: J. Biomed. Nanotechnol. contributor: fullname: Sim – volume: 4 start-page: 6629 year: 2010 end-page: 6638 ident: bb0185 article-title: Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere–serum interface: implications for stealth nanoparticle engineering publication-title: ACS Nano contributor: fullname: Moghimi – volume: 11 start-page: 785 year: 2010 end-page: 797 ident: bb0140 article-title: Complement: a key system for immune surveillance and homeostasis publication-title: Nat. Immunol. contributor: fullname: Lambris – volume: 68 start-page: 6652 year: 2008 end-page: 6660 ident: bb0105 article-title: Drug delivery with carbon nanotubes for in vivo cancer treatment publication-title: Cancer Res. contributor: fullname: Dai – volume: 5 start-page: 8454 year: 2011 end-page: 8458 ident: bb0130 article-title: Reshaping the future of nanopharmaceuticals: ad iudicium publication-title: ACS Nano contributor: fullname: Langer – volume: 181 start-page: 182 year: 2008 end-page: 189 ident: bb0285 article-title: Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice publication-title: Toxicol. Lett. contributor: fullname: Liu – volume: 2 start-page: 108 year: 2007 end-page: 113 ident: bb0090 article-title: Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type publication-title: Nat. Nanotechnol. contributor: fullname: Bianco – volume: 362 start-page: 2065 year: 2004 end-page: 2098 ident: bb0010 article-title: Electronic, thermal and mechanical properties of carbon nanotubes publication-title: Philos. Trans. A Math. Phys. Eng. Sci. contributor: fullname: Hernández – volume: 109 start-page: 113 year: 2009 end-page: 123 ident: bb0290 article-title: Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice publication-title: Toxicol. Sci. contributor: fullname: Løvik – volume: 78 start-page: 114 year: 2005 end-page: 121 ident: bb0300 article-title: BALB/c mice have more CD4+CD25 publication-title: J. Leukoc. Biol. contributor: fullname: Howard – volume: 22 start-page: 460 year: 2004 end-page: 466 ident: bb0295 article-title: Innate immune response in Th1- and Th2-dominant mouse strains publication-title: Shock contributor: fullname: Matsukawa – volume: 45 start-page: 577 year: 2006 end-page: 581 ident: bb0085 article-title: Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway publication-title: Angew. Chem. Int. Ed. contributor: fullname: Dai – volume: 7 start-page: 121 year: 2012 end-page: 131 ident: bb0120 article-title: Interaction of nanoparticles with immunocompetent cells: nanosafety considerations publication-title: Nanomedicine (UK) contributor: fullname: Italiani – volume: 146 start-page: 175 year: 2010 end-page: 181 ident: bb0135 article-title: Complement activation cascade triggered by PEG-PL engineered nanomedicines and carbon nanotubes: the challenges ahead publication-title: J. Control. Release contributor: fullname: Szebeni – volume: 103 start-page: 3357 year: 2006 end-page: 3362 ident: bb0215 article-title: Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Kostarelos – volume: 100 start-page: 211 year: 2010 end-page: 217 ident: bb0245 article-title: Functionalization impacts the effects of carbon nanotubes on the immune system of rainbow trout, publication-title: Aquat. Toxicol. contributor: fullname: Goetz – volume: 2 start-page: 338 year: 2003 end-page: 342 ident: bb0060 article-title: DNA-assisted dispersion and separation of carbon nanotubes publication-title: Nat. Mater. contributor: fullname: Tassi – volume: 125 start-page: 15174 year: 2003 end-page: 15182 ident: bb0020 article-title: Sidewall carboxylic acid functionalization of single-walled carbon nanotubes publication-title: J. Am. Chem. Soc. contributor: fullname: Khabashesku – volume: 4 start-page: 1130 year: 2008 end-page: 1132 ident: bb0225 article-title: Carbon-nanotube shape and individualization critical for renal excretion publication-title: Small contributor: fullname: Kostarelos – volume: 2 start-page: 38 year: 2007 end-page: 43 ident: bb0080 article-title: Cell-penetrating CNTs for delivery of therapeutics publication-title: Nano Today contributor: fullname: Kostarelos – volume: 63 start-page: 1000 year: 2011 end-page: 1007 ident: bb0125 article-title: Material properties in complement activation publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Hunter – volume: 4 start-page: 1019 year: 2004 end-page: 1024 ident: bb0210 article-title: Biodistribution of carbon single-wall carbon nanotubes in mice publication-title: J. Nanosci. Nanotechnol. contributor: fullname: Zhao – volume: 146 start-page: 882 year: 2005 end-page: 893 ident: bb0305 article-title: Nanoparticle-induced platelet aggregation and vascular thrombosis publication-title: Br. J. Pharmacol. contributor: fullname: Radomski – volume: 2 start-page: 249 year: 2007 end-page: 255 ident: bb0205 article-title: Shape effects of filaments versus spherical particles in flow and drug delivery publication-title: Nat. Nanotechnol. contributor: fullname: Discher – volume: 37 start-page: 177 year: 2012 end-page: 189 ident: bb0315 article-title: Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice publication-title: J. Toxicol. Sci. contributor: fullname: Ogata – volume: 108 start-page: 10952 year: 2011 end-page: 10957 ident: bb0100 article-title: Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Pizzorusso – volume: 116 start-page: 1425 year: 2006 end-page: 1434 ident: bb0150 article-title: Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 publication-title: J. Clin. Invest. contributor: fullname: Sjöholm – volume: 21 start-page: 131 year: 2009 end-page: 136 ident: bb0250 article-title: Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses publication-title: Inhal. Toxicol. contributor: fullname: Fadeel – volume: 111 start-page: 17761 year: 2007 end-page: 17764 ident: bb0280 article-title: Biodistribution of pristine single-walled carbon nanotubes in vivo publication-title: J. Phys. Chem. C contributor: fullname: Sun – volume: 7 start-page: 231 year: 2012 end-page: 243 ident: bb0235 article-title: Ex vivo impact of functionalized carbon nanotubes on human immune cells publication-title: Nanomedicine (UK) contributor: fullname: Bianco – volume: 1806 start-page: 29 year: 2010 end-page: 35 ident: bb0110 article-title: Carbon nanotubes in cancer diagnosis and therapy publication-title: Biochim. Biophys. Acta, Rev. Cancer contributor: fullname: Yu – volume: 185 start-page: 5628 year: 2010 end-page: 5636 ident: bb0155 article-title: Molecular intercommunication between the complement and coagulation systems publication-title: J. Immunol. contributor: fullname: Huber-Lang – start-page: 461 year: 2000 end-page: 462 ident: bb0025 article-title: Single-wall carbon nanotube colloids in polar solvents publication-title: Chem. Commun. contributor: fullname: Zhang – volume: 5 start-page: 4581 year: 2011 end-page: 4591 ident: bb0275 article-title: Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity publication-title: ACS Nano contributor: fullname: Yan – volume: 181 start-page: 217 year: 1988 end-page: 234 ident: bb0325 article-title: Pulmonary intravascular macrophages in domestic animal species: review of structural and functional properties publication-title: Am. J. Anat. contributor: fullname: Winkler – volume: 52 start-page: 481 year: 2012 end-page: 503 ident: bb0200 article-title: Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective publication-title: Annu. Rev. Pharmacol. Toxicol. contributor: fullname: Andresen – volume: 4 start-page: 1789 year: 2004 end-page: 1793 ident: bb0050 article-title: Dispersing single-walled carbon nanotubes with surfactants: a small angle neutron scattering study publication-title: Nano Lett. contributor: fullname: Hobbie – volume: 6 start-page: 1522 year: 2006 end-page: 1528 ident: bb0260 article-title: Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells publication-title: Nano Lett. contributor: fullname: Bianco – volume: 5 start-page: 382 year: 2010 ident: bb0230 article-title: Complement monitoring of carbon nanotubes publication-title: Nat. Nanotechnol. contributor: fullname: Hunter – volume: 4 start-page: 451 year: 2009 end-page: 456 ident: bb0310 article-title: Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice publication-title: Nat. Nanotechnol. contributor: fullname: McDonald – volume: 146 start-page: 175 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0135 article-title: Complement activation cascade triggered by PEG-PL engineered nanomedicines and carbon nanotubes: the challenges ahead publication-title: J. Control. Release doi: 10.1016/j.jconrel.2010.04.003 contributor: fullname: Moghimi – volume: 4 start-page: 6629 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0185 article-title: Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere–serum interface: implications for stealth nanoparticle engineering publication-title: ACS Nano doi: 10.1021/nn101990a contributor: fullname: Hamad – volume: 2 start-page: 108 year: 2007 ident: 10.1016/j.addr.2012.05.005_bb0090 article-title: Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2006.209 contributor: fullname: Kostarelos – volume: 4 start-page: 1019 year: 2004 ident: 10.1016/j.addr.2012.05.005_bb0210 article-title: Biodistribution of carbon single-wall carbon nanotubes in mice publication-title: J. Nanosci. Nanotechnol. doi: 10.1166/jnn.2004.146 contributor: fullname: Wang – volume: 107 start-page: 12369 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0220 article-title: Paradoxical glomerular filtration of carbon nanotubes publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0913667107 contributor: fullname: Ruggiero – volume: 2 start-page: 338 year: 2003 ident: 10.1016/j.addr.2012.05.005_bb0060 article-title: DNA-assisted dispersion and separation of carbon nanotubes publication-title: Nat. Mater. doi: 10.1038/nmat877 contributor: fullname: Zheng – volume: 9 start-page: 674 year: 2005 ident: 10.1016/j.addr.2012.05.005_bb0075 article-title: Applications of carbon nanotubes in drug delivery publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2005.10.005 contributor: fullname: Bianco – volume: 2 start-page: 47 year: 2007 ident: 10.1016/j.addr.2012.05.005_bb0070 article-title: In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2006.170 contributor: fullname: Liu – volume: 63 start-page: 1031 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0160 article-title: Complement activation by carbon nanotubes publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2011.05.012 contributor: fullname: Rybak-Smith – volume: 2 start-page: 249 year: 2007 ident: 10.1016/j.addr.2012.05.005_bb0205 article-title: Shape effects of filaments versus spherical particles in flow and drug delivery publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2007.70 contributor: fullname: Geng – volume: 6 start-page: 1522 year: 2006 ident: 10.1016/j.addr.2012.05.005_bb0260 article-title: Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells publication-title: Nano Lett. doi: 10.1021/nl061160x contributor: fullname: Dumortier – volume: 7 start-page: 231 year: 2012 ident: 10.1016/j.addr.2012.05.005_bb0235 article-title: Ex vivo impact of functionalized carbon nanotubes on human immune cells publication-title: Nanomedicine (UK) doi: 10.2217/nnm.11.101 contributor: fullname: Delogu – volume: 146 start-page: 882 year: 2005 ident: 10.1016/j.addr.2012.05.005_bb0305 article-title: Nanoparticle-induced platelet aggregation and vascular thrombosis publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0706386 contributor: fullname: Radomski – volume: 63 start-page: 1000 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0125 article-title: Material properties in complement activation publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2011.06.002 contributor: fullname: Moghimi – volume: 46 start-page: 225 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0190 article-title: Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2008.08.276 contributor: fullname: Hamad – volume: 52 start-page: 481 year: 2012 ident: 10.1016/j.addr.2012.05.005_bb0200 article-title: Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev-pharmtox-010611-134623 contributor: fullname: Moghimi – volume: 45 start-page: 3797 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0180 article-title: Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2008.05.020 contributor: fullname: Hamad – volume: 105 start-page: 1410 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0270 article-title: Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0707654105 contributor: fullname: Liu – volume: 267 start-page: 125 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0255 article-title: Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells publication-title: Toxicology doi: 10.1016/j.tox.2009.10.034 contributor: fullname: Palomäki – volume: 17 start-page: 107 year: 2007 ident: 10.1016/j.addr.2012.05.005_bb0320 article-title: Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles publication-title: J. Liposome Res. doi: 10.1080/08982100701375118 contributor: fullname: Szebeni – volume: 21 start-page: 131 year: 2009 ident: 10.1016/j.addr.2012.05.005_bb0250 article-title: Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses publication-title: Inhal. Toxicol. doi: 10.1080/08958370902942574 contributor: fullname: Witasp – volume: 4 start-page: 451 year: 2009 ident: 10.1016/j.addr.2012.05.005_bb0310 article-title: Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2009.151 contributor: fullname: Mitchell – volume: 37 start-page: 177 year: 2012 ident: 10.1016/j.addr.2012.05.005_bb0315 article-title: Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice publication-title: J. Toxicol. Sci. doi: 10.2131/jts.37.177 contributor: fullname: Yamaguchi – volume: 4 start-page: 173 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0015 article-title: Carbon nanotubes as functional excipients for nanomedicines: I. pharmaceutical properties publication-title: Nanomed. Nanotechnol. Biol. Med. doi: 10.1016/j.nano.2008.04.002 contributor: fullname: Foldvari – volume: 85 start-page: 4228 year: 2004 ident: 10.1016/j.addr.2012.05.005_bb0065 article-title: Single-molecule fluorescence microscopy and Raman spectroscopy studies of RNA bound carbon nanotubes publication-title: Appl. Phys. Lett. doi: 10.1063/1.1813631 contributor: fullname: Rao – volume: 4 start-page: 1130 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0225 article-title: Carbon-nanotube shape and individualization critical for renal excretion publication-title: Small doi: 10.1002/smll.200800323 contributor: fullname: Lacerda – volume: 5 start-page: 8454 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0130 article-title: Reshaping the future of nanopharmaceuticals: ad iudicium publication-title: ACS Nano doi: 10.1021/nn2038252 contributor: fullname: Moghimi – volume: 7 start-page: 830 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0195 article-title: Effect of functionalization of carbon nanotubes with psychosine on complement activation and protein adsorption publication-title: J. Biomed. Nanotechnol. doi: 10.1166/jbn.2011.1347 contributor: fullname: Rybak-Smith – volume: 6 start-page: e21073 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0240 article-title: Carbon nanotubes enhance cytotoxicity mediated by human lymphocytes in vitro publication-title: PLoS One doi: 10.1371/journal.pone.0021073 contributor: fullname: Sun – volume: 2 start-page: 38 year: 2007 ident: 10.1016/j.addr.2012.05.005_bb0080 article-title: Cell-penetrating CNTs for delivery of therapeutics publication-title: Nano Today doi: 10.1016/S1748-0132(07)70172-X contributor: fullname: Lacerda – volume: 280 start-page: 1253 year: 1998 ident: 10.1016/j.addr.2012.05.005_bb0030 article-title: Fullerene pipes publication-title: Science doi: 10.1126/science.280.5367.1253 contributor: fullname: Liu – volume: 100 start-page: 211 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0245 article-title: Functionalization impacts the effects of carbon nanotubes on the immune system of rainbow trout, Oncorhynchus mykiss publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2010.07.023 contributor: fullname: Klaper – volume: 109 start-page: 113 year: 2009 ident: 10.1016/j.addr.2012.05.005_bb0290 article-title: Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfp057 contributor: fullname: Nygaard – volume: 11 start-page: 785 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0140 article-title: Complement: a key system for immune surveillance and homeostasis publication-title: Nat. Immunol. doi: 10.1038/ni.1923 contributor: fullname: Ricklin – volume: 68 start-page: 6652 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0105 article-title: Drug delivery with carbon nanotubes for in vivo cancer treatment publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-1468 contributor: fullname: Liu – volume: 7 start-page: 121 year: 2012 ident: 10.1016/j.addr.2012.05.005_bb0120 article-title: Interaction of nanoparticles with immunocompetent cells: nanosafety considerations publication-title: Nanomedicine (UK) doi: 10.2217/nnm.11.169 contributor: fullname: Boraschi – volume: 12 start-page: 3381 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0045 article-title: PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead publication-title: Biomacromolecules doi: 10.1021/bm201020h contributor: fullname: Bottini – volume: 99 start-page: 1787 year: 1999 ident: 10.1016/j.addr.2012.05.005_bb0095 article-title: Nanotubes from carbon publication-title: Chem. Rev. doi: 10.1021/cr970102g contributor: fullname: Ajayan – volume: 116 start-page: 1425 year: 2006 ident: 10.1016/j.addr.2012.05.005_bb0150 article-title: Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 publication-title: J. Clin. Invest. doi: 10.1172/JCI25982 contributor: fullname: Selander – volume: 45 start-page: 577 year: 2006 ident: 10.1016/j.addr.2012.05.005_bb0085 article-title: Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.200503389 contributor: fullname: Kam – volume: 125 start-page: 15174 year: 2003 ident: 10.1016/j.addr.2012.05.005_bb0020 article-title: Sidewall carboxylic acid functionalization of single-walled carbon nanotubes publication-title: J. Am. Chem. Soc. doi: 10.1021/ja037746s contributor: fullname: Peng – volume: 124 start-page: 760 year: 2002 ident: 10.1016/j.addr.2012.05.005_bb0040 article-title: Organic functionalization of carbon nanotubes publication-title: J. Am. Chem. Soc. doi: 10.1021/ja016954m contributor: fullname: Georgakilas – volume: 5 start-page: 4581 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0275 article-title: Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity publication-title: ACS Nano doi: 10.1021/nn200283g contributor: fullname: Gao – volume: 108 start-page: 10952 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0100 article-title: Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1100930108 contributor: fullname: Al-Jamal – volume: 43 start-page: 193 year: 2006 ident: 10.1016/j.addr.2012.05.005_bb0165 article-title: Complement activation and protein adsorption by carbon nanotubes publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2005.02.006 contributor: fullname: Salvador-Morales – volume: 5 start-page: 382 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0230 article-title: Complement monitoring of carbon nanotubes publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2010.109 contributor: fullname: Moghimi – volume: 181 start-page: 217 year: 1988 ident: 10.1016/j.addr.2012.05.005_bb0325 article-title: Pulmonary intravascular macrophages in domestic animal species: review of structural and functional properties publication-title: Am. J. Anat. doi: 10.1002/aja.1001810302 contributor: fullname: Winkler – volume: 185 start-page: 5628 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0155 article-title: Molecular intercommunication between the complement and coagulation systems publication-title: J. Immunol. doi: 10.4049/jimmunol.0903678 contributor: fullname: Amara – volume: 8 start-page: 2347 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0175 article-title: Effects of covalent functionalization on the biocompatibility characteristics of multi-walled carbon nanotubes publication-title: J. Nanosci. Nanotechnol. doi: 10.1166/jnn.2008.090 contributor: fullname: Salvador-Morales – volume: 78 start-page: 114 year: 2005 ident: 10.1016/j.addr.2012.05.005_bb0300 article-title: BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25− responder T cells than C57BL/6 mice publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0604341 contributor: fullname: Chen – volume: 126 start-page: 9902 year: 2004 ident: 10.1016/j.addr.2012.05.005_bb0055 article-title: Small-angle neutron scattering from surfactant-assisted aqueous dispersions of carbon nanotubes publication-title: J. Am. Chem. Soc. doi: 10.1021/ja047451u contributor: fullname: Yurekli – volume: 5 start-page: 730 year: 2011 ident: 10.1016/j.addr.2012.05.005_bb0170 article-title: Proteins of the innate immune system crystallize on carbon nanotubes but are not activated publication-title: ACS Nano doi: 10.1021/nn102400w contributor: fullname: Ling – start-page: 461 year: 2000 ident: 10.1016/j.addr.2012.05.005_bb0025 article-title: Single-wall carbon nanotube colloids in polar solvents publication-title: Chem. Commun. doi: 10.1039/a909240d contributor: fullname: Shi – volume: 2 start-page: 369 year: 2002 ident: 10.1016/j.addr.2012.05.005_bb0035 article-title: Water solubilization of single-walled carbon nanotubes by functionalization with glucosamine publication-title: Nano Lett. doi: 10.1021/nl015680y contributor: fullname: Pompeo – volume: 362 start-page: 2065 year: 2004 ident: 10.1016/j.addr.2012.05.005_bb0010 article-title: Electronic, thermal and mechanical properties of carbon nanotubes publication-title: Philos. Trans. A Math. Phys. Eng. Sci. doi: 10.1098/rsta.2004.1430 contributor: fullname: Dresselhaus – volume: 111 start-page: 17761 year: 2007 ident: 10.1016/j.addr.2012.05.005_bb0280 article-title: Biodistribution of pristine single-walled carbon nanotubes in vivo publication-title: J. Phys. Chem. C doi: 10.1021/jp070712c contributor: fullname: Yang – volume: 1806 start-page: 29 year: 2010 ident: 10.1016/j.addr.2012.05.005_bb0110 article-title: Carbon nanotubes in cancer diagnosis and therapy publication-title: Biochim. Biophys. Acta, Rev. Cancer doi: 10.1016/j.bbcan.2010.02.004 contributor: fullname: Ji – volume: 4 start-page: 1789 year: 2004 ident: 10.1016/j.addr.2012.05.005_bb0050 article-title: Dispersing single-walled carbon nanotubes with surfactants: a small angle neutron scattering study publication-title: Nano Lett. doi: 10.1021/nl048969z contributor: fullname: Wang – volume: 3 start-page: 557 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0115 article-title: Carbon nanotubes as photoacoustic molecular imaging agents in living mice publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2008.231 contributor: fullname: De la Zerda – volume: 181 start-page: 182 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0285 article-title: Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2008.07.020 contributor: fullname: Yang – volume: 354 start-page: 56 year: 1991 ident: 10.1016/j.addr.2012.05.005_bb0005 article-title: Helical microtubules of graphitic carbon publication-title: Nature doi: 10.1038/354056a0 contributor: fullname: Iijima – volume: 103 start-page: 3357 year: 2006 ident: 10.1016/j.addr.2012.05.005_bb0215 article-title: Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0509009103 contributor: fullname: Singh – volume: 161 start-page: 283 year: 2012 ident: 10.1016/j.addr.2012.05.005_bb0145 article-title: Complement system and the brain: selected pathologies and avenues toward engineering of neurological nanomedicines publication-title: J. Control. Release doi: 10.1016/j.jconrel.2011.10.036 contributor: fullname: Lettiero – volume: 3 start-page: 216 year: 2008 ident: 10.1016/j.addr.2012.05.005_bb0265 article-title: A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2008.68 contributor: fullname: Schipper – volume: 22 start-page: 460 year: 2004 ident: 10.1016/j.addr.2012.05.005_bb0295 article-title: Innate immune response in Th1- and Th2-dominant mouse strains publication-title: Shock doi: 10.1097/01.shk.0000142249.08135.e9 contributor: fullname: Watanabe
SSID	ssj0012760
Score	2.3467662
SecondaryResourceType	review_article
Snippet	Carbon nanotubes are entities of different morphology and aspect ratios with anisotropic character. Due to their unique electronic, photonic, mechanical and...
SourceID	proquest crossref pubmed elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	1700
SubjectTerms	Animals Anisotropy Complement Activation - drug effects Complement Activation - immunology Complement system Complement System Proteins - drug effects Complement System Proteins - immunology Cytokines Humans Immune cells Immune System - cytology Immune System - drug effects Injections, Intravenous Macrophage Macrophages - metabolism Multi-walled carbon nanotubes Nanotubes, Carbon - toxicity Pharmacokinetics Single-walled carbon nanotubes
Title	Perspectives on carbon nanotube-mediated adverse immune effects
URI	https://dx.doi.org/10.1016/j.addr.2012.05.005 https://www.ncbi.nlm.nih.gov/pubmed/22634159 https://search.proquest.com/docview/1272718372
Volume	64
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3da9swEBdpy2AvY-u-si80GH1xHWzZjuWnYbaMrrARSAZ9E7IsjZXNGUnMyH-_O0m2Q7uObbAXJygklnWX0-9O97sj5JVME61MUYep4kWYcpmFiFrDlEXKGMD40rZkOVvkHy_421k6G41-dF5_P_ZfJQ1jIGtkzv6FtPsfhQF4DzKHK0gdrn8k9_nAnrQnAUquK3hpZLPatpUOLVUEYabEVswbHXxBhkif2LEPVssuP6Bet5-DWn_FHI6dZ7v0WLy09BhnvUqk9wbnkyGaU_lcQ5sHHMz7Tz5gJe1vNpVgMQHLon0FcB-AiNmVZI7rzBgXqJyC6CPbJhf2GWdceQ7Wl7mmxp31dTXMOy3L9mwpVg7c25ex7s8vbb4LP1xOwFJjgVcM7mKcLBt2uD7vcIHTwlnFmEoG0OuAHDGwUGAgj8r3s4vz_gCK5ZZg3j-G51u51MCrd7oJ09zks1jssrxL7ning5ZOW-6RkW6OyS3XhnR3TE7mrn757pQuBzre5pSe0PlQ2Xx3n7zeVy66aqhTLnpNuahXLuqUi3rlekA-vZst35yFvgNHqFLGtkjz4ADpDTi1plaF5glPmcw1j4qKRfW0zqTRkUK3NZEmMVMJCF6mkYrzysSVSh6Sw2bV6MeEws4Btj7JNK80-vSVUrHRHCPQuUyZHpOgW0Px3RVaEV0G4qXAFRe44iLKBKz4mGTdMgsPFR0EFKAVv_3ey04mAuwoHo7JRq_ajQCJM8BpSc7G5JETVj8PcFEA7GXFk3-861Nye_jjPCOH23Wrn5ODTd2-8Hr3E-flnYE
link.rule.ids	315,782,786,27933,27934
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Perspectives+on+carbon+nanotube-mediated+adverse+immune+effects&rft.jtitle=Advanced+drug+delivery+reviews&rft.au=Andersen%2C+Alina+J.&rft.au=Wibroe%2C+Peter+P.&rft.au=Moghimi%2C+S.+Moein&rft.date=2012-12-01&rft.pub=Elsevier+B.V&rft.issn=0169-409X&rft.eissn=1872-8294&rft.volume=64&rft.issue=15&rft.spage=1700&rft.epage=1705&rft_id=info:doi/10.1016%2Fj.addr.2012.05.005&rft.externalDocID=S0169409X12001846
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0169-409X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0169-409X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0169-409X&client=summon