A protocol for the classification of powder compression characteristics
Protocol for powder compression analysis as a test to identify functionality-related characteristics of particles in a formulation development programme. In this paper, a structured protocol for powder compression analysis as a test to assess the mechanical properties of particles in a formulation d...
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| Published in: | European journal of pharmaceutics and biopharmaceutics Vol. 80; no. 1; pp. 209 - 216 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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Amsterdam
Elsevier B.V
2012
Elsevier |
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| Abstract | Protocol for powder compression analysis as a test to identify functionality-related characteristics of particles in a formulation development programme.
In this paper, a structured protocol for powder compression analysis as a test to assess the mechanical properties of particles in a formulation development programme is presented. First, the sequence of classification steps of the protocol is described, and secondly, the protocol is illustrated using compression data of six powders of two model substances, sodium chloride and mannitol. From powder compression data, a set of compression variables are derived, and by using critical values of these variables, the stages expressed during the compression of the powders are identified and the powders are classified into groups with respect to the expression of particle rearrangement, particle fragmentation and particle plastic deformation during compression. It is concluded that the proposed protocol could, in a satisfactorily way, describe and distinguish between the powders regarding their compression behaviour. Hence, the protocol could be a valuable tool for the formulation scientist to comprehensively assess important functionality-related characteristics of drugs and excipients. |
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| AbstractList | In this paper, a structured protocol for powder compression analysis as a test to assess the mechanical properties of particles in a formulation development programme is presented. First, the sequence of classification steps of the protocol is described, and secondly, the protocol is illustrated using compression data of six powders of two model substances, sodium chloride and mannitol. From powder compression data, a set of compression variables are derived, and by using critical values of these variables, the stages expressed during the compression of the powders are identified and the powders are classified into groups with respect to the expression of particle rearrangement, particle fragmentation and particle plastic deformation during compression. It is concluded that the proposed protocol could, in a satisfactorily way, describe and distinguish between the powders regarding their compression behaviour. Hence, the protocol could be a valuable tool for the formulation scientist to comprehensively assess important functionality-related characteristics of drugs and excipients. Protocol for powder compression analysis as a test to identify functionality-related characteristics of particles in a formulation development programme. In this paper, a structured protocol for powder compression analysis as a test to assess the mechanical properties of particles in a formulation development programme is presented. First, the sequence of classification steps of the protocol is described, and secondly, the protocol is illustrated using compression data of six powders of two model substances, sodium chloride and mannitol. From powder compression data, a set of compression variables are derived, and by using critical values of these variables, the stages expressed during the compression of the powders are identified and the powders are classified into groups with respect to the expression of particle rearrangement, particle fragmentation and particle plastic deformation during compression. It is concluded that the proposed protocol could, in a satisfactorily way, describe and distinguish between the powders regarding their compression behaviour. Hence, the protocol could be a valuable tool for the formulation scientist to comprehensively assess important functionality-related characteristics of drugs and excipients. |
| Author | Klevan, Ingvild Alderborn, Göran Nordström, Josefina |
| Author_xml | – sequence: 1 givenname: Josefina surname: Nordström fullname: Nordström, Josefina email: josefina.nordstrom@farmaci.uu.se organization: Department of Pharmacy, Uppsala University, Uppsala, Sweden – sequence: 2 givenname: Ingvild surname: Klevan fullname: Klevan, Ingvild organization: Department of Pharmacy, University of Tromsø, Tromsø, Norway – sequence: 3 givenname: Göran surname: Alderborn fullname: Alderborn, Göran organization: Department of Pharmacy, Uppsala University, Uppsala, Sweden |
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| Keywords | Classification system Particle mechanical properties Kawakita Powder compression Compression parameters Heckel Particle Compression Pharmaceutical technology Classification Mechanical properties Powder |
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| Snippet | Protocol for powder compression analysis as a test to identify functionality-related characteristics of particles in a formulation development programme.
In... In this paper, a structured protocol for powder compression analysis as a test to assess the mechanical properties of particles in a formulation development... |
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| SubjectTerms | Biological and medical sciences Chemistry, Pharmaceutical - methods Classification system Compression parameters Compressive Strength Drug Compounding - methods Excipients - chemistry General pharmacology Heckel Kawakita Mannitol - chemistry Medical sciences Models, Theoretical Multivariate Analysis Particle mechanical properties Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powder compression Powders - chemistry Principal Component Analysis - methods Sodium Chloride - chemistry |
| Title | A protocol for the classification of powder compression characteristics |
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