Di-(2-ethylhexyl) phthalate possesses an adjuvant effect in a subcutaneous injection model with BALB/c mice
The prevalence of allergic airway diseases is rapidly increasing in Western Europe and North America and the introduction of anthropogenic chemicals may explain a part of this increase. Recently, our group found that degradation products from several commonly used phthalate plasticizers possess adju...
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| Published in: | Toxicology letters Vol. 125; no. 1; pp. 11 - 18 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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15-12-2001
Amsterdam Elsevier Science |
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| Abstract | The prevalence of allergic airway diseases is rapidly increasing in Western Europe and North America and the introduction of anthropogenic chemicals may explain a part of this increase. Recently, our group found that degradation products from several commonly used phthalate plasticizers possess adjuvant activity in an animal model. Mono-2-ethylhexyl phthalate, which is the degradation product of di-(2-ethylhexyl) phthalate (DEHP), was among these substances. These findings prompted the study of the adjuvant activity of the parent compound itself. Thus, DEHP was studied in a model using ovalbumin (OA) as the model antigen. OA was injected subcutaneously in the neck region of BALB/cJ mice with or without DEHP. The levels of OA-specific IgE, IgG1 and IgG2a antibodies in sera were measured by ELISA. Adjuvant effect, defined as a statistically significant increase in antibody level, was observed with IgG1 at a concentration of 2000 μg DEHP/ml after both one and two boosters. |
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| AbstractList | The prevalence of allergic airway diseases is rapidly increasing in Western Europe and North America and the introduction of anthropogenic chemicals may explain a part of this increase. Recently, our group found that degradation products from several commonly used phthalate plasticizers possess adjuvant activity in an animal model. Mono-2-ethylhexyl phthalate, which is the degradation product of di-(2-ethylhexyl) phthalate (DEHP), was among these substances. These findings prompted the study of the adjuvant activity of the parent compound itself. Thus, DEHP was studied in a model using ovalbumin (OA) as the model antigen. OA was injected subcutaneously in the neck region of BALB/cJ mice with or without DEHP. The levels of OA-specific IgE, IgG1 and IgG2a antibodies in sera were measured by ELISA. Adjuvant effect, defined as a statistically significant increase in antibody level, was observed with IgG1 at a concentration of 2000 microg DEHP/ml after both one and two boosters. The prevalence of allergic airway diseases is rapidly increasing in Western Europe and North America and the introduction of anthropogenic chemicals may explain a part of this increase. Recently, our group found that degradation products from several commonly used phthalate plasticizers possess adjuvant activity in an animal model. Mono-2-ethylhexyl phthalate, which is the degradation product of di-(2-ethylhexyl) phthalate (DEHP), was among these substances. These findings prompted the study of the adjuvant activity of the parent compound itself. Thus, DEHP was studied in a model using ovalbumin (OA) as the model antigen. OA was injected subcutaneously in the neck region of BALB/cJ mice with or without DEHP. The levels of OA-specific IgE, IgG1 and IgG2a antibodies in sera were measured by ELISA. Adjuvant effect, defined as a statistically significant increase in antibody level, was observed with IgG1 at a concentration of 2000 mu g DEHP/ml after both one and two boosters. The prevalence of allergic airway diseases is rapidly increasing in Western Europe and North America and the introduction of anthropogenic chemicals may explain a part of this increase. Recently, our group found that degradation products from several commonly used phthalate plasticizers possess adjuvant activity in an animal model. Mono-2-ethylhexyl phthalate, which is the degradation product of di-(2-ethylhexyl) phthalate (DEHP), was among these substances. These findings prompted the study of the adjuvant activity of the parent compound itself. Thus, DEHP was studied in a model using ovalbumin (OA) as the model antigen. OA was injected subcutaneously in the neck region of BALB/cJ mice with or without DEHP. The levels of OA-specific IgE, IgG1 and IgG2a antibodies in sera were measured by ELISA. Adjuvant effect, defined as a statistically significant increase in antibody level, was observed with IgG1 at a concentration of 2000 μg DEHP/ml after both one and two boosters. |
| Author | Thor Larsen, Søren Thygesen, Peter My Lund, Rikke Damgård Nielsen, Gunnar Melchior Poulsen, Otto |
| Author_xml | – sequence: 1 givenname: Søren surname: Thor Larsen fullname: Thor Larsen, Søren email: stl@ami.dk organization: National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen Ø, Denmark – sequence: 2 givenname: Rikke surname: My Lund fullname: My Lund, Rikke organization: National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen Ø, Denmark – sequence: 3 givenname: Gunnar surname: Damgård Nielsen fullname: Damgård Nielsen, Gunnar organization: National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen Ø, Denmark – sequence: 4 givenname: Peter surname: Thygesen fullname: Thygesen, Peter organization: Department of Pharmacology, Royal Danish School of Pharmacy, Copenhagen, Denmark – sequence: 5 givenname: Otto surname: Melchior Poulsen fullname: Melchior Poulsen, Otto organization: National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen Ø, Denmark |
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| Keywords | IgG Allergy Di-(2-ethylhexyl) phthalate Adjuvant effect DEHP IgE Immunoglobulins Toxicity Chemical compound Rodentia Vertebrata Experimental disease Mammalia Plasticizer Mouse Animal Adjuvant |
| Language | English |
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| SubjectTerms | Adjuvant effect Adjuvants, Immunologic - toxicity Allergy Animals Biological and medical sciences bis(2-ethylhexyl) phthalate DEHP Di-(2-ethylhexyl) phthalate Diethylhexyl Phthalate - administration & dosage Diethylhexyl Phthalate - toxicity Experimental and animal immunopathology. Animal models Female IgE IgG Immunoglobulin E - blood Immunoglobulin G - blood Immunopathology Injections, Subcutaneous Medical sciences Mice Mice, Inbred BALB C Ovalbumin - immunology Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology |
| Title | Di-(2-ethylhexyl) phthalate possesses an adjuvant effect in a subcutaneous injection model with BALB/c mice |
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