NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells

OBJECTIVETo determine whether the activation of nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase and the increase of superoxide anion production by angiotensin II is dependent upon the activation of the ERK-MAPK pathway. METHODSHypertension was induced in Sprague–Dawley rats by infusing...

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Bibliographic Details
Published in:	Journal of hypertension Vol. 21; no. 5; pp. 927 - 936
Main Authors:	Laplante, Marc-André, Wu, Rong, El Midaoui, Adil, de Champlain, Jacques
Format:	Journal Article
Language:	English
Published:	England Lippincott Williams & Wilkins, Inc 01-05-2003
Subjects:	Angiotensin II - pharmacology Animals Antihypertensive Agents - pharmacology Antioxidants - pharmacology Aorta - cytology Aorta - drug effects Aorta - metabolism Blood Pressure - drug effects Disease Models, Animal Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Activation - drug effects Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Flavonoids - antagonists & inhibitors Genistein - antagonists & inhibitors Hypertension - metabolism Losartan - pharmacology Male Mitogen-Activated Protein Kinase 1 - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Models, Cardiovascular Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - enzymology NADPH Oxidases - drug effects NADPH Oxidases - metabolism Rats Rats, Sprague-Dawley Superoxides - metabolism Thioctic Acid - pharmacology Vasoconstrictor Agents - pharmacology
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