Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4+ T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1)

• Published in: Journal of medical virology Vol. 79; no. 5; pp. 639 - 646
• Main Authors: Franzese, Ornella, Adamo, Riccardo, Pollicita, Michela, Comandini, Alessandro, Laudisi, Anastasia, Perno, Carlo Federico, Aquaro, Stefano, Bonmassar, Enzo
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-05-2007; Wiley-Liss
• Subjects: activation; Biological and medical sciences; CD4; CD4-Positive T-Lymphocytes - microbiology; Cell Nucleus - metabolism; Cells, Cultured; Cytoplasm - metabolism; Down-Regulation; Fundamental and applied biological sciences. Psychology; HIV Infections - metabolism; HIV-1; hTERT; Human immunodeficiency virus 1; Human viral diseases; Humans; Infectious diseases; Medical sciences; Microbiology; Miscellaneous; Phosphorylation; telomerase; Telomerase - metabolism; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; HIV-1; Immunopathology; Phosphorylation; HIV-1 virus; Enzyme; Retroviridae; AIDS; Immune deficiency; Lentivirus; Virus; Infection; CD4; Viral disease; T-Lymphocyte; Human immunodeficiency virus; hTERT; activation; Telomerase
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.20855

Human immunodeficiency virus type 1 (HIV‐1) infection is characterized by a progressive decrease of CD4+ T cells accompanied by other immune dysfunctions. Telomerase is transiently activated in lymphocytes during activation and is able to compensate for the progressive telomeric loss that occurs at each cell division, contributing to ensure the telomere length necessary for multiple proliferative events. The effect of HIV‐1 infection on telomerase activity and on the expression of some of the factors involved in its regulation in CD4+ T cells was investigated. Telomerase was found to be downregulated in both nuclear and cytoplasmic compartments, together with an impairment of human telomerase reverse transcriptase (hTERT) expression and of the cell machinery involved in hTERT phosporylation. J. Med. Virol. 79:639–646, 2007. © 2007 Wiley‐Liss, Inc.