Using adaptive model predictive control to customize maintenance therapy chemotherapeutic dosing for childhood acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a common childhood cancer in which nearly one-quarter of patients experience a disease relapse. However, it has been shown that individualizing therapy for childhood ALL patients by adjusting doses based on the blood concentration of active drug metabolite could...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of theoretical biology Vol. 264; no. 3; pp. 990 - 1002
Main Authors:	Noble, Sarah L., Sherer, Eric, Hannemann, Robert E., Ramkrishna, Doraiswami, Vik, Terry, Rundell, Ann E.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 07-06-2010
Subjects:	Algorithms Antimetabolites, Antineoplastic - therapeutic use Biological systems Child Dose-Response Relationship, Drug Drug scheduling Erythrocyte Indices Hematopoietic stem cell differentiation Humans Mercaptopurine - therapeutic use Models, Biological Nonlinear model predictive control Personalized medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Predictive Value of Tests Sensitivity and Specificity Treatment Outcome Hematopoietic stem cell differentiation Nonlinear model predictive control Personalized medicine Drug scheduling Biological systems
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!