Physicochemical properties of the mouse plasmacytoma cell membranes with modified phospholipids

Earlier work from our laboratory has demonstrated that the modification of membrane phospholipid composition markedly retards secretion of immunoglobulin G1 by mouse plasmacytoma MOPC-31C cells. In the present study, we examined the physicochemical properties of lipid vesicles prepared from these ce...

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Bibliographic Details
Published in:	Japanese journal of medical science & biology Vol. 38; no. 5-6; p. 201
Main Authors:	Nakano, A, Higashijima, T, Akamatsu, Y
Format:	Journal Article
Language:	English
Published:	Japan 1985
Subjects:	Animals Cell Line Cell Membrane - ultrastructure Fatty Acids - analysis Magnetic Resonance Spectroscopy Membrane Fluidity Membrane Lipids - analysis Mice Phospholipids - analysis Plasmacytoma - ultrastructure
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Summary:	Earlier work from our laboratory has demonstrated that the modification of membrane phospholipid composition markedly retards secretion of immunoglobulin G1 by mouse plasmacytoma MOPC-31C cells. In the present study, we examined the physicochemical properties of lipid vesicles prepared from these cells with modified phospholipids by analyzing temperature dependence of 1H NMR signal line-widths of fatty-acyl chains. The results suggest that the export of IgG1 is affected by the local microenvironment of membranes rather than the bulk fluidity.
ISSN:	0021-5112
DOI:	10.7883/yoken1952.38.201