STING controls T cell memory fitness during infection through T cell-intrinsic and IDO-dependent mechanisms

Stimulator of interferon genes (STING) signaling has been extensively studied in inflammatory diseases and cancer, while its role in T cell responses to infection is unclear. Using strains engineered to induce different levels of c-di-AMP, we found that high STING signals impaired T cell memory upon...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 3; p. e2205049120
Main Authors:	Quaney, Michael J, Pritzl, Curtis J, Luera, Dezzarae, Newth, Rebecca J, Knudson, Karin M, Saxena, Vikas, Guldenpfennig, Caitlyn, Gil, Diana, Rae, Chris S, Lauer, Peter, Daniels, Mark A, Teixeiro, Emma
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 17-01-2023
Subjects:	Apoptosis BIM protein Biological Sciences CD8 antigen CD8-Positive T-Lymphocytes Cell survival Fitness Immunological memory Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Infections Inflammatory diseases Listeria monocytogenes Lymphocytes Lymphocytes T Memory cells Memory T Cells Protein folding Receptors, Antigen, T-Cell - genetics Signal strength Signal Transduction Signaling Stimulators T cell receptors Tryptophan 2,3-dioxygenase STING TCR CD8 T cell memory
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