Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors

Testicular germ cell tumors (TGCTs) are exceptionally sensitive to genotoxic chemotherapy, resulting in a high cure rate for the young men presenting with these malignancies. However, this treatment is associated with significant toxicity, and a subset of malignant TGCTs demonstrate chemoresistance....

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Bibliographic Details
Published in:	Cancers Vol. 13; no. 9; p. 2045
Main Authors:	Loehr, Amanda R, Pierpont, Timothy M, Gelsleichter, Eric, Galang, Anabella Maria D, Fernandez, Irma R, Moore, Elizabeth S, Guo, Matthew Z, Miller, Andrew D, Weiss, Robert S
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 23-04-2021 MDPI
Subjects:	Amino acids Antipsychotics Cancer therapies Cell differentiation Chemoresistance Chemotherapy Fibroblasts Genotoxicity Immunosuppressive agents Laboratory animals Malignancy Metastasis Neoplasia Pluripotency Psychotropic drugs Salinomycin Stem cell transplantation Stem cells Testes Testicular cancer Thioridazine Tumors Xenografts United States > US testicular germ cell tumor cancer stem cells embryonal carcinoma pluripotency differentiation therapy nonseminoma thioridazine
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